Výsledky vyhledávání

Abacavir Increases Purinergic P2X7 Receptor Activation by ATP: Does a Pro-inflammatory Synergism Underlie Its Cardiovascular Toxicity?

Autor: Collado-Díaz V, Martinez-Cuesta MÁ, Blanch-Ruiz MA, Sánchez-López A, García-Martínez P, Peris JE, Usach I, Ivorra MD, Lacetera A, Martín-Santamaría S, Esplugues JV, Alvarez A

Publikováno v: Frontiers in Pharmacology
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

The cardiovascular toxicity of Abacavir is related to its purinergic structure. Purinergic P2X7-receptors (P2X7R), characterized by activation by high concentrations of ATP and with high plasticity, seem implicated. We appraise the nature of the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::125bf9f8054ddc88530ac67ac9f1053a
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=9372

Zobrazit plný text záznamu

Antihypertensive Mechanism of Lactoferrin-Derived Peptides: Angiotensin Receptor Blocking Effect

Autor: Fernández-Musoles R, Castelló-Ruiz M, Arce C, Manzanares P, Ivorra MD, Salom JB

Publikováno v: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Looking for antihypertensive mechanisms beyond ACE inhibition, we assessed whether lactoferrin (LF)-derived peptides can act as receptor blockers to inhibit vasoconstriction induced by angiotensin II or endothelin-1. The lactoferricin B (LfcinB)-deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::b9a58cb192d5f1e8864237b1bdbc047d
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=2815

Zobrazit plný text záznamu

Different b-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways : implications in the relaxant response of rat conductance and resistance vessels

Autor: Flacco, N, Segura, V, Perez-Aso, M, Estrada, S, Seller, JF, Jiménez-Altayó, F, Noguera, MA, D'Ocon, P, Vila, E, Ivorra, MD

Publikováno v: Repositorio UdeA
Universidad de Antioquia
instacron:Universidad de Antioquia

To analyse the relative contribution of b1-, b2- and b3-adrenoceptors (Adrb) to vasodilatation in conductance and resistance vessels, assessing the role of cAMP and/or NO/cGMP signalling pathways. Experimental Approach Rat mesenteric resistance arter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::6e3bc18cf0a6de8536610024913564de

Zobrazit plný text záznamu

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure etiology and correlates to clinical variables

Autor: Montó F, Oliver E, Vicente D, Rueda J, Agüero J, Almenar L, Ivorra MD, Barettino D, D'Ocon P

Publikováno v: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Downregulation of ß(1)- adrenergic receptors (ß(1)-ARs) and increased expression/function of G-protein-coupled receptor kinase 2 (GRK2) have been observed in human heart failure, but changes in expression of other ARs and GRKs have not been establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::fef657bcc533bf074ae8bdb79bea525d
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1474

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání