Výsledky vyhledávání - "Ivor J Benjamin"

Akademický článek

Rescue of αB Crystallin (HSPB5) Mutants Associated Protein Aggregation by Co-Expression of HSPB5 Partners.

Autor: Rasha M Hussein, Ivor J Benjamin, Harm H Kampinga

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126761 (2015)

HSPB5 (also called αB-crystallin) is a ubiquitously expressed small heat shock protein. Mutations in HSPB5 have been found to cause cataract, but are also associated with a subgroup of myofibrillar myopathies. Cells expressing each of these HSPB5 mu

Externí odkaz: https://doaj.org/article/e826ff61f2594cd1b984e38e7b4f16a1

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Akademický článek

Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome.

Autor: Julianne H Grose, Kelsey Langston, Xiaohui Wang, Shayne Squires, Soumyajit Banerjee Mustafi, Whitney Hayes, Jonathan Neubert, Susan K Fischer, Matthew Fasano, Gina Moore Saunders, Qiang Dai, Elisabeth Christians, E Douglas Lewandowski, Peipei Ping, Ivor J Benjamin

Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0133994 (2015)

Small Heat Shock Proteins (sHSPs) are molecular chaperones that transiently interact with other proteins, thereby assisting with quality control of proper protein folding and/or degradation. They are also recruited to protect cells from a variety of

Externí odkaz: https://doaj.org/article/1aa7329692af4e7eac7ae8233e3ebade

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Akademický článek

The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.

Autor: Heng B Xie, Anthony Cammarato, Namakkal S Rajasekaran, Huali Zhang, Jennifer A Suggs, Ho-Chen Lin, Sanford I Bernstein, Ivor J Benjamin, Kent G Golic

Publikováno v: PLoS Genetics, Vol 9, Iss 6, p e1003544 (2013)

Dominant mutations in the alpha-B crystallin (CryAB) gene are responsible for a number of inherited human disorders, including cardiomyopathy, skeletal muscle myopathy, and cataracts. The cellular mechanisms of disease pathology for these disorders a

Externí odkaz: https://doaj.org/article/4789041d94c142bda94469f8185de730

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Akademický článek

HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice.

Autor: Takahiro Ishiwata, András Orosz, Xiaohui Wang, Soumyajit Banerjee Mustafi, Gregory W Pratt, Elisabeth S Christians, Sihem Boudina, E Dale Abel, Ivor J Benjamin

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42118 (2012)

CryAB (HspB5) and HspB2, two small heat shock genes located adjacently in the vertebrate genome, are hypothesized to play distinct roles. Mice lacking both cryab and hspb2 (DKO) are viable and exhibit adult-onset degeneration of skeletal muscle but c

Externí odkaz: https://doaj.org/article/c45782e940b3482bb78cda534ab3ae3b

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Akademický článek

Collagen‐Specific HSP47+ Myofibroblasts and CD163+ Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS‐CoV‐2 Infections

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 4 (2023)

Background Cardiac fibrosis complicates SARS‐CoV‐2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of increased HSP47 (heat shock protein 47), a stress‐inducible chaperone protein that re

Externí odkaz: https://doaj.org/article/dcff5f8bd058444885b891f250ecd75e

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Akademický článek

Carvedilol Phenocopies PGC-1α Overexpression to Alleviate Oxidative Stress, Mitochondrial Dysfunction and Prevent Doxorubicin-Induced Toxicity in Human iPSC-Derived Cardiomyocytes

Autor: Nnamdi Uche, Qiang Dai, Shuping Lai, Kurt Kolander, Mai Thao, Elizabeth Schibly, Xavier Sendaydiego, Jacek Zielonka, Ivor J. Benjamin

Publikováno v: Antioxidants, Vol 12, Iss 8, p 1585 (2023)

Doxorubicin (DOX), one of the most effective and widely used anticancer drugs, has the major limitation of cancer treatment-related cardiotoxicity (CTRTOX) in the clinic. Reactive oxygen species (ROS) generation and mitochondrial dysfunction are well

Externí odkaz: https://doaj.org/article/71b6f0ff86774d1ea6015b264d5c301e

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Akademický článek

Transcription Factor EB Activation Rescues Advanced αB‐Crystallin Mutation‐Induced Cardiomyopathy by Normalizing Desmin Localization

Autor: Xiucui Ma, Kartik Mani, Haiyan Liu, Attila Kovacs, John T. Murphy, Layla Foroughi, Brent A. French, Carla J. Weinheimer, Aldi Kraja, Ivor J. Benjamin, Joseph A. Hill, Ali Javaheri, Abhinav Diwan

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)

Background Mutations in αB‐crystallin result in proteotoxic cardiomyopathy with desmin mislocalization to protein aggregates. Intermittent fasting (IF) is a novel approach to activate transcription factor EB (TFEB), a master regulator of the autop

Externí odkaz: https://doaj.org/article/ad805593a61c4dcbbca1bbb8a105465c

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