The selective COX-2 inhibitor celecoxib modulates sphingolipid synthesiss⃞

Autor: Susanne Schiffmann, Jessica Sandner, Ronald Schmidt, Kerstin Birod, Ivonne Wobst, Helmut Schmidt, Carlo Angioni, Gerd Geisslinger, Sabine Grösch

Publikováno v: Journal of Lipid Research, Vol 50, Iss 1, Pp 32-40 (2009)

Sphingolipids such as ceramides (Cers) play important roles in cell proliferation, apoptosis, and cell cycle regulation. An increased Cer level is linked to the cytotoxic effects of several chemotherapeutics. Various selective cyclooxygenase-2 (COX-2

Externí odkaz: https://doaj.org/article/f5caba274d5f44caba4e7defd379fb55

Cellular membranes function as a storage compartment for celecoxib

Autor: Clemens Glaubitz, Dieter Steinhilber, Susanne Schiffmann, Thorsten J. Maier, Sabine Grösch, Kerstin Birod, Gerd Geisslinger, Carlo Angioni, Ivonne Wobst, Jakob J. Lopez, Marika Hoffmann

Publikováno v: Maier, T, Schiffmann, S, Wobst, I, Birod, K, Angioni, C, Hoffmann, M, Lopez, J J, Glaubitz, C, Steinhilber, D, Geisslinger, G & Grösch, S 2009, ' Cellular membranes function as a storage compartment for celecoxib ' Journal of Molecular Medicine, vol. 87, no. 10, pp. 981-93 . https://doi.org/10.1007/s00109-009-0506-8

Celecoxib is a selective cyclooxygenase-2-(COX-2)-inhibitor used to treat inflammation and pain and prevents colorectal cancer in patients at high doses by affecting several non-COX-2 proteins. However, celecoxib concentrations appropriate to inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e42fda1f2c45aee47d9d3eed49c7f3ad
https://doi.org/10.1007/s00109-009-0506-8

The anti-proliferative potency of celecoxib is not a class effect of coxibs

Autor: Susanne Schiffmann, Astrid Janssen, Carlo Angioni, Thorsten J. Maier, Sabine Grösch, Ivonne Wobst, Gerd Geisslinger, Heike Corban-Wilhelm

Publikováno v: Schiffmann, S, Maier, T, Wobst, I, Janssen, A, Corban-Wilhelm, H, Angioni, C, Geisslinger, G & Grösch, S 2008, ' The anti-proliferative potency of celecoxib is not a class effect of coxibs ', Biochemical Pharmacology, vol. 76, no. 2, pp. 179-87 . https://doi.org/10.1016/j.bcp.2008.04.017

Celecoxib, a COX-2 (cyclooxygenase-2)-selective inhibitor (coxib), is the only NSAID (non-steroidal anti-inflammatory drug) that has been approved for adjuvant treatment of patients with familial adenomatous polyposis. To investigate if the anti-prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d8baca0018664797bdcea612e0178d
https://doi.org/10.1016/j.bcp.2008.04.017

Ceramide synthases and ceramide levels are increased in breast cancer tissue

Autor: Eugen Ruckhäberle, Jörn Lötsch, Susanne Schiffmann, Ivonne Wobst, Gerd Geisslinger, Hanns Ackermann, Jessica Sandner, Sabine Grösch, Kerstin Birod, Helmut Schmidt, Manfred Kaufmann, Carlo Angioni

Publikováno v: Carcinogenesis. 30(5)

Several in vitro studies have correlated dysfunction of the sphingolipid-signaling pathway with promotion of tumor cell growth as well as progression and resistance of tumors to chemotherapeutic agents. As ceramides (Cer) constitute the structural ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfdf813f3af7274ea1fb657aabba5c11
https://pubmed.ncbi.nlm.nih.gov/19279183

p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells

Autor: Astrid Janssen, Sabine Grösch, Susanne Schiffmann, Thorsten J. Maier, Kerstin Birod, Gerd Geisslinger, Ivonne Wobst

Publikováno v: Janssen, A, Schiffmann, S, Birod, K, Maier, T, Wobst, I, Geisslinger, G & Grösch, S 2008, ' p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells ' Biochemical and Biophysical Research Communications, vol. 365, no. 4, pp. 698-703 . https://doi.org/10.1016/j.bbrc.2007.11.051

S-ibuprofen which inhibits the cyclooxygenase-1/-2 and R-ibuprofen which shows no COX-inhibition at therapeutic concentrations have anti-carcinogenic effects in human colon cancer cells; however, the molecular mechanisms for these effects are still u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c64873c83802e5901384ab1be6ea9d9
https://pure.au.dk/portal/da/publications/p53-is-important-for-the-antiproliferative-effect-of-ibuprofen-in-colon-carcinoma-cells(e3a669a8-e974-4b6a-a1f7-08612c4c0fff).html