Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Ivonne Petermann"'
Autor:
Lynnette R. Ferguson, Dug Yeo Han, Claudia Huebner, Ivonne Petermann, Murray L. Barclay, Richard B. Gearry, Alan McCulloch, Pieter S. Demmers
Publikováno v:
Gastroenterology Research and Practice, Vol 2009 (2009)
Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammat
Externí odkaz:
https://doaj.org/article/4defd19b15824339a91e7eb50be54e35
Publikováno v:
Inflammatory Bowel Diseases. 16:282-295
Background: The era of genome-wide association studies (GWAS) has led to the identification of many inflammatory bowel disease (IBD)–associated single-nucleotide polymorphisms (SNPs) with unknown function. The next step would be to identify the fun
Autor:
Murray L. Barclay, Dug Yeo Han, Martin Philpott, Pieter Demmers, Alan McCulloch, Claudia Huebner, Brian L. Browning, Richard B. Gearry, Ivonne Petermann, Lynnette R. Ferguson
Publikováno v:
Inflammatory Bowel Diseases. 15:1784-1793
Background: Single nucleotide polymorphisms (SNPs) in the multidrug transporter MDR1 have been associated with inflammatory bowel disease (IBD) in different studies. However, the data are highly controversial. Recently, 6 haplotype tagging SNPs (tSNP
Autor:
Martin Philpott, Murray L. Barclay, Martin A. Kennedy, Andrew N. Shelling, Rebecca L. Roberts, Lynnette R. Ferguson, Dug Yeo Han, Ivonne Petermann, Brian L. Browning, Claudia Huebner, Richard B. Gearry
Publikováno v:
Human Immunology. 70:440-446
Bacterial sensing is crucial for appropriate response by the innate and adaptive immune system against invading microorganisms. Single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition, CARD15 and TLR4, increased the risk of
Autor:
Alan McCulloch, Claudia Huebner, Martin Philpott, Pieter Demmers, Richard B. Gearry, Murray L. Barclay, Lynnette R. Ferguson, Dug Yeo Han, Ivonne Petermann
Publikováno v:
The Open Gastroenterology Journal. 2:50-56
Background: The IBD5 (MIM# 606348) chromosomal region on 5q31 contains the genes for organic cation transporters, OCTN1 and OCTN2, and has been associated with susceptibility to adult onset CD. While several studies ar- gue that OCTN1 and OCTN2 are t
Autor:
Claudia Huebner, Lynnette R. Ferguson, Ivonne Petermann, Richard B. Gearry, Murray L. Barclay, Brian L. Browning, Andrew N. Shelling
Publikováno v:
The American Journal of Gastroenterology. 102:2504-2512
Published association studies of the TLR4 Asp299Gly polymorphism and inflammatory bowel disease (IBD) in caucasian populations have inconsistent results. We tested two TLR4 variants for association with IBD in the New Zealand caucasian population and
Autor:
Murray L. Barclay, Claudia Huebner, Ivonne Petermann, Richard B. Gearry, Brian L. Browning, Lynnette R. Ferguson, Pieter Demmers, Alan McCulloch, Andrew N. Shelling
Publikováno v:
Inflammatory Bowel Diseases. 13:1069-1076
Background: Variants in the DLG5 gene have been associated with inflammatory bowel disease (IBD) in samples from some, but not all populations. In particular, 2 nonsynonymous single-nucleotide polymorphisms (SNPs), R30Q (rs1248696) and P1371Q (rs2289
Autor:
Lynnette R. Ferguson, Brian L. Browning, Claudia Huebner, Ivonne Petermann, Andrew N. Shelling
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 16:1185-1192
Accurate measurement of allele frequencies between population groups with differing sensitivities to disease is fundamental to genetic epidemiology. Genotyping errors can markedly influence the biological conclusions of a study. This issue may be esp
Autor:
Christoph Peters, Thomas Toneff, Richard A. Bundey, Katalin F. Medzihradszky, Ivonne Petermann, Ruthellen Miller, Bradford W. Gibson, Jessica Dehnert, Thomas Reinheckel, William S. Lane, Anna Logvinova, Matthew Bogyo, Doron C. Greenbaum, John M. Neveu, Sukkid Yasothornsrikul, Birgit Schilling, Vivian Hook, Paul K. Goldsmith
Publikováno v:
Proceedings of the National Academy of Sciences. 100:9590-9595
Multistep proteolytic mechanisms are essential for converting proprotein precursors into active peptide neurotransmitters and hormones. Cysteine proteases have been implicated in the processing of proenkephalin and other neuropeptide precursors. Alth
Autor:
Thomas Reinheckel, Wilhelm Haverkamp, Kerstin Gläser, Desmond J. Tobin, Jörg Stypmann, Wolfgang W. Schmahl, Wera Roth, Rainer Matthias, Gerold Mönnig, Günter Breithardt, Ivonne Petermann, Christoph Peters
Publikováno v:
Proceedings of the National Academy of Sciences. 99:6234-6239
Dilated cardiomyopathy is a frequent cause of heart failure and is associated with high mortality. Progressive remodeling of the myocardium leads to increased dimensions of heart chambers. The role of intracellular proteolysis in the progressive remo