Výsledky vyhledávání - "Ivonne M J J van Vlijmen-Willems"

Akademický článek

Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skin.

Autor: Patrick A M Jansen, Diana Rodijk-Olthuis, Edward J Hollox, Marijke Kamsteeg, Geuranne S Tjabringa, Gys J de Jongh, Ivonne M J J van Vlijmen-Willems, Judith G M Bergboer, Michelle M van Rossum, Elke M G J de Jong, Martin den Heijer, Andrea W M Evers, Mieke Bergers, John A L Armour, Patrick L J M Zeeuwen, Joost Schalkwijk

Publikováno v: PLoS ONE, Vol 4, Iss 3, p e4725 (2009)

BackgroundPrevious studies have extensively documented antimicrobial and chemotactic activities of beta-defensins. Human beta-defensin-2 (hBD-2) is strongly expressed in lesional psoriatic epidermis, and recently we have shown that high beta-defensin

Externí odkaz: https://doaj.org/article/b6b1e9ff82104ec2b1aca2b327370234

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Akademický článek

Novel methodologies for host-microbe interactions and microbiome-targeted therapeutics in 3D organotypic skin models

Autor: Gijs Rikken, Luca D. Meesters, Patrick A. M. Jansen, Diana Rodijk-Olthuis, Ivonne M. J. J. van Vlijmen-Willems, Hanna Niehues, Jos P. H. Smits, Peter Oláh, Bernhard Homey, Joost Schalkwijk, Patrick L. J. M. Zeeuwen, Ellen H. van den Bogaard

Publikováno v: Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)

Abstract Background Following descriptive studies on skin microbiota in health and disease, mechanistic studies on the interplay between skin and microbes are on the rise, for which experimental models are in great demand. Here, we present a novel me

Externí odkaz: https://doaj.org/article/b56885fd3404401293b7da40f98e3c16

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Carboxamide Derivatives Are Potential Therapeutic AHR Ligands for Restoring IL-4 Mediated Repression of Epidermal Differentiation Proteins

Autor: Gijs Rikken, Noa J. M. van den Brink, Ivonne M. J. J. van Vlijmen-Willems, Piet E. J. van Erp, Lars Pettersson, Jos P. H. Smits, Ellen H. van den Bogaard

Publikováno v: International Journal of Molecular Sciences, 23, 3
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1773
International Journal of Molecular Sciences, Vol 23, Iss 1773, p 1773 (2022)
International Journal of Molecular Sciences, 23

Atopic dermatitis (AD) is a common T-helper 2 (Th2) lymphocyte-mediated chronic inflammatory skin disease characterized by disturbed epidermal differentiation (e.g., filaggrin (FLG) expression) and diminished skin barrier function. Therapeutics targe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c254127ec9fe1513c0441876fdb7e29c
https://doi.org/10.3390/ijms23031773

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Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification

Autor: Tsing, Cheng, Kiyotaka, Hitomi, Ivonne M J J, van Vlijmen-Willems, Gys J, de Jongh, Kanae, Yamamoto, Koji, Nishi, Colin, Watts, Thomas, Reinheckel, Joost, Schalkwijk, Patrick L J M, Zeeuwen

Publikováno v: The Journal of biological chemistry. 281(23)

Cystatin M/E is a high affinity inhibitor of the asparaginyl endopeptidase legumain, and we have previously reported that both proteins are likely to be involved in the regulation of stratum corneum formation in skin. Although cystatin M/E contains a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d6641cdfaabf1e48ef49f5295da6a49
https://pubmed.ncbi.nlm.nih.gov/16565075

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