Výsledky vyhledávání - "Ivonne Löffler"

Akademický článek

Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

Autor: Marc Dorenkamp, Madina Nasiry, Dilvin Semo, Sybille Koch, Ivonne Löffler, Gunter Wolf, Holger Reinecke, Rinesh Godfrey

Publikováno v: Cells, Vol 12, Iss 3, p 513 (2023)

Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to at

Externí odkaz: https://doaj.org/article/27fb78a69b7e44b7acd3f47666002886

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Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis

Autor: Johannes Waltenberger, Marc Dorenkamp, Rinesh Godfrey, Kallipatti Sanjith Shanmuganathan, Ulrich Müller, Ivonne Löffler, Nicolle Müller, Jörg P. Müller, Gunter Wolf, Henny Schulten, Frank-D. Böhmer

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

Diabetes mellitus (DM) is a major cardiovascular risk factor contributing to cardiovascular complications by inducing vascular cell dysfunction. Monocyte dysfunction could contribute to impaired arteriogenesis response in DM patients. DM monocytes sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2836c794691382f5ee80cd0fee9489d
http://link.springer.com/article/10.1038/s41598-018-33014-9

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Prostaglandin E2 Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP

Autor: Ivonne Löffler, Ignacio Rubio, Raimund W. Kinne, Anne Jansen, Elke Kunisch, Leslie J. Crofford, Shinichi Kawai, Mohit Kapoor, Fumiaki Kojima

Publikováno v: The Journal of Immunology. 183:1328-1336

The present study investigated the influence of PGE2, E prostanoid (EP) receptors, and their signaling pathways on matrix metalloproteinase (MMP)-1 and IL-6 expression in synovial fibroblasts (SFs) from rheumatoid arthritis (RA) patients. RASFs expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0129fcb2913ae6afe62b483550f223ff
https://doi.org/10.4049/jimmunol.0900801

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Hyperglycemia-Induced Deregulation of Thioredoxin System Contributes to the Functional Impairment of Monocytes Resulting in Compromised Collateral Remodelling in Diabetes Mellitus

Autor: Alessa Ringel, Ulrich A Miller, Gunter Wolf, Ivonne Löffler, Frank-D. Böhmer, Johannes Waltenberger, Henny Schulten, Rinesh Godfrey, Sanjith Kallipatti Shanmuganathan, Nicolle Miiller

Publikováno v: Free Radical Biology and Medicine. 87:S24-S25

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70f62b4a744ab99debec500982ed31c7
https://doi.org/10.1016/j.freeradbiomed.2015.10.068

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Identification and quantitative confirmation of dinitropyrenes and 3-nitrobenzanthrone as major mutagens in contaminated sediments

Autor: Sini Flückiger-Isler, Tobias Schulze, Stefanie Lohrmann, Mahmoud Bataineh, Werner Brack, Jiri Neca, Urte Lübcke-von Varel, Ivonne Löffler, Miroslav Machala

Publikováno v: Environment International, Vol 44, Iss, Pp 31-39 (2012)

Polar fractions of a sediment extract of the industrial area of Bitterfeld, Germany, have been subjected for effect-directed identification of mutagens using the Ames fluctuation assay with TA98. Mutagenicity could be well recovered in several second

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5f17a4aa7c29fd6a2bb6dd34a0858fd
https://pubmed.ncbi.nlm.nih.gov/22336528

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Polar compounds dominate in vitro effects of sediment extracts

Autor: Jana M. Weiss, Katerina Pencikova, Miroslav Machala, Jan Vondráček, Jiri Neca, Urte Lübcke-von Varel, Marja H. Lamoree, Werner Brack, Sini Flückiger-Isler, Miroslav Ciganek, Georg Streck, Georg Reifferscheid, Ivonne Löffler, Lenka Pálková

Publikováno v: Environmental Science and Technology, 45(6), 2384-2390. American Chemical Society
Lubecke-von Varel, U, Machala, M, Ciganek, M, Neca, J, Pencikova, K, Palkova, L, Vondracek, J, Löffler, I, Streck, G, Reifferscheid, G, Flueckiger-Isler, S, Weiss, J M, Lamoree, M H & Brack, W 2011, ' Polar compounds dominate in vitro effects of sediment extracts ', Environmental Science and Technology, vol. 45, no. 6, pp. 2384-2390 . https://doi.org/10.1021/es103381y

Sediment extracts from three polluted sites of the river Elbe basin were fractionated using a novel on-line fractionation procedure. Resulting fractions were screened for mutagenic, aryl hydrocarbon (AhR)-mediated, transthyretin (TTR)-binding and est

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4667a24c88938e68119136975e646b4c
http://publications.jrc.ec.europa.eu/repository/handle/JRC61139

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Akademický článek

Cardiovascular risk due to diabetes mellitus in patients with chronic kidney disease—prospective data from the German Chronic Kidney Disease cohort.

Autor: Ruhe, Johannes¹ (AUTHOR), Nadal, Jennifer² (AUTHOR), Bärthlein, Barbara³ (AUTHOR), Meiselbach, Heike⁴ (AUTHOR), Schultheiss, Ulla T^5,6 (AUTHOR), Kotsis, Fruzsina^5,6 (AUTHOR), Stockmann, Helena⁷ (AUTHOR), Krane, Vera⁸ (AUTHOR), Sommerer, Claudia⁹ (AUTHOR), Löffler, Ivonne¹ (AUTHOR), Saritas, Turgay¹⁰ (AUTHOR), Kielstein, Jan T¹¹ (AUTHOR), Sitter, Thomas¹² (AUTHOR), Schneider, Markus P⁴ (AUTHOR), Schmid, Matthias² (AUTHOR), Wanner, Christoph⁸ (AUTHOR), Eckardt, Kai-Uwe^4,7 (AUTHOR), Wolf, Gunter¹ (AUTHOR), Busch, Martin¹ (AUTHOR) martin.busch@med.uni-jena.de

Publikováno v: Clinical Kidney Journal. Nov2023, Vol. 16 Issue 11, p2032-2040. 9p.

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TGF-β and fibrosis in different organs — molecular pathway imprints

Autor: Dirk Pohlers, Andreas Stallmach, Raimund W. Kinne, Carola Leipner, Cornelia K. Müller, Gunter Wolf, Julia Brenmoehl, Stefan Schultze-Mosgau, Ivonne Löffler

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (8):746-756

The action of transforming-growth-factor (TGF)-beta following inflammatory responses is characterized by increased production of extracellular matrix (ECM) components, as well as mesenchymal cell proliferation, migration, and accumulation. Thus, TGF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccf1c2d14273026f8ec580582d87748

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