Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Ivonne, Archibeque"'
Autor:
Xin, Luo, Ivonne, Archibeque, Ken, Dellamaggiore, Kate, Smither, Oliver, Homann, James Russell, Lipford, Dane, Mohl
Publikováno v:
iScience. 25:103985
The success of small molecule therapeutics that promotes degradation of critical cancer targets has fueled an intense effort to mimic this activity with bispecific molecules called PROTACs (proteolysis targeting chimeras). The simultaneous binding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dbb0320a876e23b1de3b66460906b3
https://doi.org/10.1016/j.isci.2022.103985
https://doi.org/10.1016/j.isci.2022.103985
Autor:
Yu Li, Victor J. Cee, Pragathi Achanta, Aaron S. Rapaport, Brian A. Lanman, Hui-Ling Wang, Tao Osgood, Karen Rex, Deanna Mohn, Christopher Mohr, Andres Plata Stapper, Jude Canon, J. Russell Lipford, Anne Y. Saiki, Ivonne Archibeque
Publikováno v:
Cancer Research. 81:1285-1285
Sotorasib (formerly known as AMG 510), the first-in-class KRASG12C inhibitor, has demonstrated promising clinical efficacy in KRAS p.G12C mutant cancers. Sotorasib binds to KRASG12C through a unique interaction with a surface groove created by side-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f55f0aad6d5ec1c3d67a915480758900
https://doi.org/10.1158/1538-7445.am2021-1285
https://doi.org/10.1158/1538-7445.am2021-1285
Autor:
Ivonne Archibeque, Steven G. Elliott, Scott Powers, Paul D. Kassner, Leigh Busse, J E V Watson, Norma Rogers, W Brown, Angus M. Sinclair, G E Arnold, Ken C. Q. Nguyen
Publikováno v:
British Journal of Cancer
Erythropoietin receptor (EpoR) has been reported to be overexpressed in tumours and has raised safety concerns regarding the use of erythropoiesis-stimulating agents (ESAs) to treat anaemia in cancer patients. To investigate the potential for EpoR to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39aa0ad8978a276837a9ed697bda6feb
http://europepmc.org/articles/PMC2275479
http://europepmc.org/articles/PMC2275479
Publikováno v:
Journal of biomolecular screening. 20(4)
The Bispecific T-cell Engager (BiTE) antibody modality is a clinically validated immunotherapeutic approach for targeting tumors. Using T-cell dependent cellular cytotoxicity (TDCC) assays, we measure the percentage of specific cytotoxicity induced w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ef932d5f3c05952444b53590a8d453
https://pubmed.ncbi.nlm.nih.gov/25477202
https://pubmed.ncbi.nlm.nih.gov/25477202
Autor:
Bee-Chun Sun, Renee Emkey, Ivonne Archibeque, Laurie B. Schenkel, Liqin Liu, Josie Han Lee, Violeta Yu, Stephanie D. Geuns-Meyer, Jeanne Pistillo
Publikováno v:
Experimental hematology. 41(5)
Small molecule inhibitors of Janus kinase (JAK) family members (JAK1, JAK2, JAK3, and Tyk2) are currently being pursued as potential new modes of therapy for a variety of diseases, including the inhibition of JAK2 for the treatment of myeloproliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8bef17a7c8945d061c546456a7c0b3
https://pubmed.ncbi.nlm.nih.gov/23340136
https://pubmed.ncbi.nlm.nih.gov/23340136
Optimization and utilization of the SureFire phospho-STAT5 assay for a cell-based screening campaign
Autor:
Cherylene Plewa, Angus M. Sinclair, Christina Binder, Ivonne Archibeque, Yu Sun, Renee Emkey, Amy Lafayette
Publikováno v:
Assay and drug development technologies. 6(1)
The family of signal transducers and activators of transcription (STATs) consists of seven transcription factors that respond to a variety of cytokines, hormones, and growth factors. STATs are activated by tyrosine phosphorylation, which results in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cb875f7f607b2597c74af3080739bdb
https://pubmed.ncbi.nlm.nih.gov/18336085
https://pubmed.ncbi.nlm.nih.gov/18336085
Autor:
Ivonne Archibeque, Linslee M. Luke, S. Thomas Carmichael, Tim Nolan, Songlin Li, Janneth P. Momiy
Publikováno v:
Experimental neurology. 193(2)
Stroke induces axonal sprouting in peri-infarct cortex. A set of growth-associated genes important in axonal sprouting in peripheral nervous system regeneration and cortical development has recently been defined. The expression profiles of these grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd732dc058522d207ca4d18ba9cbc00
https://pubmed.ncbi.nlm.nih.gov/15869933
https://pubmed.ncbi.nlm.nih.gov/15869933
Autor:
Bethany Mattson, Ling Wang, Rachael L. Brake, Ali-Samer Al-Assaad, Gary Means, Ivonne Archibeque, Liqin Liu, Leigh Busse, Kirk Henne, Tim Cushing, Angus M. Sinclair, Graham Molineux, Charlie Starnes, Daniela Metz, Allison Drew
Publikováno v:
Blood. 118:4964-4964
Abstract 4964 Immune receptors such as the B cell receptor (BCR) require key signaling intermediate phosphatidylinositol-3 kinase delta (PI3Kδ) for normal immune cell survival, development and function. PI3Kδ is a class IA lipid kinase, is expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49c1f3ed3809c013c2d6fba017805cc9
https://doi.org/10.1182/blood.v118.21.4964.4964
https://doi.org/10.1182/blood.v118.21.4964.4964
Autor:
Ivonne Archibeque, Angus M. Sinclair, Ling Wang, Liqin Liu, Bee-Chun Sun, Marc Payton, Jeanne Pistillo, Graham Molineux
Publikováno v:
Blood. 118:4963-4963
Abstract 4963 Phosphatidylinositol-3 kinase delta (PI3Kδ) is a class IA lipid kinase expressed primarily in leukocytes and is a key signaling molecule for immune receptors such as the B cell receptor (BCR). Dysregulated BCR-PI3Kδ signaling has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d4593bfdb28bc9915b9525f8a589045
https://doi.org/10.1182/blood.v118.21.4963.4963
https://doi.org/10.1182/blood.v118.21.4963.4963
Autor:
Violeta Yu, Graham Molineux, Laurie B. Schenkel, Josie Lee, Liqin Liu, Jeanne Pistillo, Stephanie D. Geuns-Meyer, Renee Emkey, Angus M. Sinclair, Ivonne Archibeque
Publikováno v:
Blood. 118:5150-5150
Abstract 5150 Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis (MF) are myeloproliferative disorders (MPDs) characterized by a chronic over-production of cells of one or more blood cell lineages and/or bone marrow fibrosis whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e4de02d239e32cdac34d21c31180af0b
https://doi.org/10.1182/blood.v118.21.5150.5150
https://doi.org/10.1182/blood.v118.21.5150.5150