Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Ivo P Touw"'
Autor:
Joseph Dicken, Alexander Mildner, Dena Leshkowitz, Ivo P Touw, Shay Hantisteanu, Steffen Jung, Yoram Groner
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77490 (2013)
Classical dendritic cells (cDC) are specialized antigen-presenting cells mediating immunity and tolerance. cDC cell-lineage decisions are largely controlled by transcriptional factor regulatory cascades. Using an in vivo cell-specific targeting of Ru
Externí odkaz:
https://doaj.org/article/fe3b793da454463fbf2dc57f27a6f47b
Autor:
Karishma K Palande, Renee Beekman, Lotte E van der Meeren, H Berna Beverloo, Peter J M Valk, Ivo P Touw
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e16340 (2011)
The antioxidant peroxiredoxin (PRDX) protein family comprises 6 members, which are implicated in a variety of cellular responses, including growth factor signal transduction. PRDX4 resides in the endoplasmic reticulum (ER), where it locally controls
Externí odkaz:
https://doaj.org/article/aa86a339bdfb4e6aa17eb5b9f976f862
Autor:
Renée Beekman, Marijke Valkhof, Stefan J Erkeland, Erdogan Taskesen, Veronika Rockova, Justine K Peeters, Peter J M Valk, Bob Löwenberg, Ivo P Touw
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26537 (2011)
Acute myeloid leukemia (AML) results from multiple genetic and epigenetic aberrations, many of which remain unidentified. Frequent loss of large chromosomal regions marks haplo-insufficiency as one of the major mechanisms contributing to leukemogenes
Externí odkaz:
https://doaj.org/article/964aa76b293d4d1f93e7d2fe879265e4
Autor:
Arturo Sanz, Daniela Ungureanu, Tuija Pekkala, Rob Ruijtenbeek, Ivo P Touw, Riet Hilhorst, Olli Silvennoinen
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18522 (2011)
Janus kinase 2 (JAK2) initiates signaling from several cytokine receptors and is required for biological responses such as erythropoiesis. JAK2 activity is controlled by regulatory proteins such as Suppressor of Cytokine Signaling (SOCS) proteins and
Externí odkaz:
https://doaj.org/article/69ae644367c84bc2b99c88a21596b32e
Autor:
Jacqueline Feyen, Zhen Ping, Lanpeng Chen, Claire van Dijk, Tim V. D. van Tienhoven, Paulina M. H. van Strien, Remco M. Hoogenboezem, Michiel J. W. Wevers, Mathijs A. Sanders, Ivo P. Touw, Marc H. G. P. Raaijmakers
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Innate and adaptive immune cells function in the homeostasis of haematopoietic stem cells (HSC). Here the authors show that myeloid cells are able to reduce the function of HSCs via interferon signaling through a neutrophil-NK cell dependent process.
Externí odkaz:
https://doaj.org/article/9f3d9e52bb044dac844af641eab95cd4
Autor:
Wei Zhang, Emanuele Gioacchino, Cansu Koyunlar, Joke Zink, Hans de Looper, Kirsten J. Gussinklo, Remco Hoogenboezem, Dennis Bosch, Eric Bindels, Ivo P. Touw, Emma de Pater
Publikováno v:
HemaSphere, Vol 7, p e94325dc (2023)
Externí odkaz:
https://doaj.org/article/30747f125c114725a39d2c81bfa3fc96
Autor:
Francesca Fioredda, Julia Skokowa, Hannah Tamary, Michail Spanoudakis, Piero Farruggia, Antonio Almeida, Daniela Guardo, Petter Höglund, Peter E. Newburger, Jan Palmblad, Ivo P. Touw, Cornelia Zeidler, Alan J. Warren, David C. Dale, Karl Welte, Carlo Dufour, Helen A. Papadaki
Publikováno v:
HemaSphere, Vol 7, Iss 4, p e872 (2023)
Neutropenia, as an isolated blood cell deficiency, is a feature of a wide spectrum of acquired or congenital, benign or premalignant disorders with a predisposition to develop myelodysplastic neoplasms/acute myeloid leukemia that may arise at any age
Externí odkaz:
https://doaj.org/article/8d24a5729708435dac85ec75944ea448
Autor:
Cansu Koyunlar, Emanuele Gioacchino, Disha Vadgama, Hans de Looper, Joke Zink, Mariette N. D. ter Borg, Remco Hoogenboezem, Marije Havermans, Mathijs A. Sanders, Eric Bindels, Elaine Dzierzak, Ivo P. Touw, Emma de Pater
Publikováno v:
Blood advances, 7(10), 2082-2093. American Society of Hematology
The first hematopoietic stem cells (HSCs) are formed through endothelial-to-hematopoietic transition (EHT) during embryonic development. The transcription factor GATA2 is a crucial regulator of EHT and HSC function throughout life. Because patients w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3652163368a1dc54e4934546e737a66e
https://pure.eur.nl/en/publications/2abc2b14-76c7-4053-a73d-bbc731786991
https://pure.eur.nl/en/publications/2abc2b14-76c7-4053-a73d-bbc731786991
Autor:
Patricia A. Olofsen, Dennis A. Bosch, Hans W. J. de Looper, Paulina M. H. van Strien, Remco M. Hoogenboezem, Onno Roovers, Vincent H. J. van der Velden, Eric M. J. Bindels, Emma M. De Pater, Ivo P. Touw
Publikováno v:
British Journal of Haematology, 200(1), 79-86. Wiley-Blackwell Publishing Ltd
Severe congenital neutropenia (SCN) patients are prone to develop myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML). Leukaemic progression of SCN is associated with the early acquisition of CSF3R mutations in haematopoietic progenitor c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315da5a6237131896968a5e8a5195dfa
http://www.scopus.com/inward/record.url?scp=85138749245&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85138749245&partnerID=8YFLogxK
Autor:
Enguerran Mouly, Hussein Ghamlouch, Veronique Della-Valle, Laurianne Scourzic, Cyril Quivoron, Damien Roos-Weil, Patrycja Pawlikowska, Véronique Saada, M'Boyba K. Diop, Cécile K. Lopez, Michaela Fontenay, Philippe Dessen, Ivo P. Touw, Thomas Mercher, Said Aoufouchi, Olivier A. Bernard
Publikováno v:
Blood Advances, Vol 2, Iss 6, Pp 703-714 (2018)
Abstract: The TET2 gene encodes an α-ketoglutarate–dependent dioxygenase able to oxidize 5-methylcytosine into 5-hydroxymethylcytosine, which is a step toward active DNA demethylation. TET2 is frequently mutated in myeloid malignancies but also in
Externí odkaz:
https://doaj.org/article/720969fbdbde47808b2dd1855942e27e