Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Ivo J Huijbers"'
Autor:
Muhammad Assad Aslam, Mir Farshid Alemdehy, Colin E J Pritchard, Ji-Ying Song, Fitriari Izzatunnisa Muhaimin, Ruud H Wijdeven, Ivo J Huijbers, Jacques Neefjes, Heinz Jacobs
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210526 (2019)
C9orf82 protein, or conserved anti-apoptotic protein 1 or caspase activity and apoptosis inhibitor 1 (CAAP1) has been implicated as a negative regulator of the intrinsic apoptosis pathway by modulating caspase expression and activity. In contrast, an
Externí odkaz:
https://doaj.org/article/8c34312eba3d49a2bd51d7e0f713c299
Autor:
Ivo J Huijbers, Rahmen Bin Ali, Colin Pritchard, Miranda Cozijnsen, Min‐Chul Kwon, Natalie Proost, Ji‐Ying Song, Hilda de Vries, Jitendra Badhai, Kate Sutherland, Paul Krimpenfort, Ewa M Michalak, Jos Jonkers, Anton Berns
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 2, Pp 212-225 (2014)
Abstract Human cancers modeled in Genetically Engineered Mouse Models (GEMMs) can provide important mechanistic insights into the molecular basis of tumor development and enable testing of new intervention strategies. The inherent complexity of these
Externí odkaz:
https://doaj.org/article/eb23552beda443f999513453e1461b4a
Autor:
Ivo J Huijbers, Marjan Iravani, Sergey Popov, David Robertson, Safa Al-Sarraj, Chris Jones, Clare M Isacke
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9808 (2010)
BackgroundGlioblastoma multiforme (GBM, WHO grade IV) is the most common and most malignant of astrocytic brain tumors, and is associated with rapid invasion into neighboring tissue. In other tumor types it is well established that such invasion invo
Externí odkaz:
https://doaj.org/article/d2b20241bfd44b7782343c3f5e9990a2
Autor:
Corinne Fasquelle, Arnaud Sartelet, Wanbo Li, Marc Dive, Nico Tamma, Charles Michaux, Tom Druet, Ivo J Huijbers, Clare M Isacke, Wouter Coppieters, Michel Georges, Carole Charlier
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000666 (2009)
We herein describe the positional identification of a 2-bp deletion in the open reading frame of the MRC2 receptor causing the recessive Crooked Tail Syndrome in cattle. The resulting frame-shift reveals a premature stop codon that causes nonsense-me
Externí odkaz:
https://doaj.org/article/f6af2d7b44a64acbb646ebcadb96833f
Autor:
Tim J. W. Harmsen, Colin E. J. Pritchard, Joey Riepsaame, Henri J. van de Vrugt, Ivo J. Huijbers, Hein te Riele
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Promiscuous activity of the Streptococcus pyogenes DNA nuclease CRISPR-Cas9 can result in destruction of a successfully modified sequence obtained by templated repair of a Cas9-induced DNA double-strand break. To avoid re-cutting, additional
Externí odkaz:
https://doaj.org/article/5a302beab37f4b3db70dfe7a0b5f39e5
Autor:
Carmen A, Widmer, Ismar, Klebic, Natalya, Domanitskaya, Morgane, Decollogny, Denise, Howald, Myriam, Siffert, Paul, Essers, Zuzanna, Nowicka, Nadine, Stokar-Regenscheit, Marieke, van de Ven, Renske, de Korte-Grimmerink, José A, Galván, Colin E J, Pritchard, Ivo J, Huijbers, Wojciech, Fendler, Conchita, Vens, Sven, Rottenberg
Publikováno v:
Cancer research communications. 2(10)
In recent years platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b3ae48feead58acc9625a899980606f
https://pubmed.ncbi.nlm.nih.gov/36467895
https://pubmed.ncbi.nlm.nih.gov/36467895
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
In recent years, platinum (Pt) drugs have been found to be especially efficient to treat patients with cancers that lack a proper DNA damage response, for example, due to dysfunctional BRCA1. Despite this knowledge, we are still missing helpful marke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f298b83d5f8eaac3e632f9259a7bf3b
https://doi.org/10.1158/2767-9764.c.6550914.v1
https://doi.org/10.1158/2767-9764.c.6550914.v1
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
gRNA oligos used for the generation of Lrrc8a or Lrrc8d-knockout cell lines, organoids and tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8fab8ff46482b5da388cda400e92e7
https://doi.org/10.1158/2767-9764.22545336
https://doi.org/10.1158/2767-9764.22545336
Autor:
Sven Rottenberg, Conchita Vens, Wojciech Fendler, Ivo J. Huijbers, Colin E.J. Pritchard, José A. Galván, Renske de Korte-Grimmerink, Marieke van de Ven, Nadine Stokar-Regenscheit, Zuzanna Nowicka, Paul Essers, Myriam Siffert, Denise Howald, Morgane Decollogny, Natalya Domanitskaya, Ismar Klebic, Carmen A. Widmer
TIDE analysis and tumor growth curves of Kaplan Meyer survival graphs shown in main Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a79cb2411409008734ed6096065899b
https://doi.org/10.1158/2767-9764.22545345
https://doi.org/10.1158/2767-9764.22545345
Autor:
Jos Jonkers, Peter Bouwman, Arnab Ray Chaudhuri, Haico van Attikum, Jeroen Essers, Dik C. van Gent, Bing Xia, Ivo J. Huijbers, Colin E.J. Pritchard, Marieke van de Ven, Renske de Korte-Grimmerink, Sjoerd Klarenbeek, Kerstin Hahn, Nicole S. Verkaik, Anne Paulien Drenth, Eline van der Burg, Maria Valeria Lattanzio, Roebi de Bruijn, Hanneke van der Gulden, Magdalena B. Rother, Stefan J. Roobol, Gerarda van de Kamp, Chirantani Mukherjee, Emilia M. Pulver
The BRCA1 tumor suppressor gene encodes a multidomain protein for which several functions have been described. These include a key role in homologous recombination repair (HRR) of DNA double-strand breaks, which is shared with two other high-risk her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::786ed1996ad6e1a9b8f8a8dc4137aca5
https://doi.org/10.1158/0008-5472.c.6513568.v1
https://doi.org/10.1158/0008-5472.c.6513568.v1