Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Ivo G Gut"'
Autor:
Miranda D Stobbe, Gian A Thun, Andrea Diéguez-Docampo, Meritxell Oliva, Justin P Whalley, Emanuele Raineri, Ivo G Gut
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 11, p e1007496 (2019)
The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes positive selection as the sol
Externí odkaz:
https://doaj.org/article/6eed99736a684118816fba2838116440
Autor:
Dirk S. Paul, Andrew E. Teschendorff, Mary A.N. Dang, Robert Lowe, Mohammed I. Hawa, Simone Ecker, Huriya Beyan, Stephanie Cunningham, Alexandra R. Fouts, Anita Ramelius, Frances Burden, Samantha Farrow, Sophia Rowlston, Karola Rehnstrom, Mattia Frontini, Kate Downes, Stephan Busche, Warren A. Cheung, Bing Ge, Marie-Michelle Simon, David Bujold, Tony Kwan, Guillaume Bourque, Avik Datta, Ernesto Lowy, Laura Clarke, Paul Flicek, Emanuele Libertini, Simon Heath, Marta Gut, Ivo G Gut, Willem H. Ouwehand, Tomi Pastinen, Nicole Soranzo, Sabine E. Hofer, Beate Karges, Thomas Meissner, Bernhard O. Boehm, Corrado Cilio, Helena Elding Larsson, Åke Lernmark, Andrea K. Steck, Vardhman K. Rakyan, Stephan Beck, R. David Leslie
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
The incidence of type 1 diabetes is increasing, potentially implicating non-genetic factors. Here the authors conduct an epigenome-wide association study in disease-discordant twins and find increased DNA methylation variability at genes associated w
Externí odkaz:
https://doaj.org/article/74847440186d44ba8513e31e9862b708
Autor:
Mirko Francesconi, Bruno Di Stefano, Clara Berenguer, Luisa de Andrés-Aguayo, Marcos Plana-Carmona, Maria Mendez-Lago, Amy Guillaumet-Adkins, Gustavo Rodriguez-Esteban, Marta Gut, Ivo G Gut, Holger Heyn, Ben Lehner, Thomas Graf
Publikováno v:
eLife, Vol 8 (2019)
Forced transcription factor expression can transdifferentiate somatic cells into other specialised cell types or reprogram them into induced pluripotent stem cells (iPSCs) with variable efficiency. To better understand the heterogeneity of these proc
Externí odkaz:
https://doaj.org/article/1e7e360cc36942ebad3d8db9321366ca
Autor:
Núria Hermosilla-Albala, Felipe Ennes Silva, Sebastián Cuadros-Espinoza, Claudia Fontsere, Alejandro Valenzuela-Seba, Harvinder Pawar, Marta Gut, Joanna L. Kelley, Sandra Ruibal-Puertas, Pol Alentorn-Moron, Armida Faella, Esther Lizano, Izeni Farias, Tomas Hrbek, Joao Valsecchi, Ivo G. Gut, Jeffrey Rogers, Kyle Kai-How Farh, Lukas F. K. Kuderna, Tomas Marques-Bonet, Jean P. Boubli
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Despite showing the greatest primate diversity on the planet, genomic studies on Amazonian primates show very little representation in the literature. With 48 geolocalized high coverage whole genomes from wild uakari monkeys, we present the
Externí odkaz:
https://doaj.org/article/2fd9910959ba4493b9d6650ad059eb13
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Despite the wealth of publicly available single-cell datasets, our understanding of distinct resident immune cells and their unique features in diverse human organs remains limited. To address this, we compiled a meta-analysis dataset of 114
Externí odkaz:
https://doaj.org/article/0124732cb7f644b6a87552e2e7fd3055
Autor:
Sara Santos, Cláudia S Baptista, Rui M V Abreu, Estela Bastos, Irina Amorim, Ivo G Gut, Fátima Gärtner, Raquel Chaves
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83673 (2013)
Human ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this
Externí odkaz:
https://doaj.org/article/24f4a010860643d3b998acae10bd0d64
Autor:
James D McKay, Therese Truong, Valerie Gaborieau, Amelie Chabrier, Shu-Chun Chuang, Graham Byrnes, David Zaridze, Oxana Shangina, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Ivana Holcatova, Vladimir Janout, Lenka Foretova, Pagona Lagiou, Dimitrios Trichopoulos, Simone Benhamou, Christine Bouchardy, Wolfgang Ahrens, Franco Merletti, Lorenzo Richiardi, Renato Talamini, Luigi Barzan, Kristina Kjaerheim, Gary J Macfarlane, Tatiana V Macfarlane, Lorenzo Simonato, Cristina Canova, Antonio Agudo, Xavier Castellsagué, Ray Lowry, David I Conway, Patricia A McKinney, Claire M Healy, Mary E Toner, Ariana Znaor, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf Neto, Leticia Fernández Garrote, Stefania Boccia, Gabriella Cadoni, Dario Arzani, Andrew F Olshan, Mark C Weissler, William K Funkhouser, Jingchun Luo, Jan Lubiński, Joanna Trubicka, Marcin Lener, Dorota Oszutowska, Stephen M Schwartz, Chu Chen, Sherianne Fish, David R Doody, Joshua E Muscat, Philip Lazarus, Carla J Gallagher, Shen-Chih Chang, Zuo-Feng Zhang, Qingyi Wei, Erich M Sturgis, Li-E Wang, Silvia Franceschi, Rolando Herrero, Karl T Kelsey, Michael D McClean, Carmen J Marsit, Heather H Nelson, Marjorie Romkes, Shama Buch, Tomoko Nukui, Shilong Zhong, Martin Lacko, Johannes J Manni, Wilbert H M Peters, Rayjean J Hung, John McLaughlin, Lars Vatten, Inger Njølstad, Gary E Goodman, John K Field, Triantafillos Liloglou, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A González, J Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Kay-Tee Khaw, Timothy Key, H Bas Bueno-de-Mesquita, Petra H M Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Göran Hallmans, Kim Overvad, Anne Tjønneland, Merethe Kumle, Elio Riboli, Kristjan Välk, Tõnu Vooder, Andres Metspalu, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Hélène Blanché, Ivo G Gut, Pilar Galan, Simon Heath, Mia Hashibe, Richard B Hayes, Paolo Boffetta, Mark Lathrop, Paul Brennan
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001333 (2011)
Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to up
Externí odkaz:
https://doaj.org/article/846c8a4060ef41a19a022b13df570b81
Autor:
Sven Michel, Liming Liang, Martin Depner, Norman Klopp, Andreas Ruether, Ashish Kumar, Michaela Schedel, Christian Vogelberg, Erika von Mutius, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Otto Laub, Burkhard Simma, Thomas Frischer, Jon Genuneit, Ivo G Gut, Stefan Schreiber, Mark Lathrop, Thomas Illig, Michael Kabesch
Publikováno v:
PLoS ONE, Vol 5, Iss 11, p e13894 (2010)
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWA
Externí odkaz:
https://doaj.org/article/9c74797b20024749b86216fc65012d83
Autor:
Vardhman K Rakyan, Thomas Hildmann, Karen L Novik, Jörn Lewin, Jörg Tost, Antony V Cox, T Dan Andrews, Kevin L Howe, Thomas Otto, Alexander Olek, Judith Fischer, Ivo G Gut, Kurt Berlin, Stephan Beck
Publikováno v:
PLoS Biology, Vol 2, Iss 12, p e405 (2004)
The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological proces
Externí odkaz:
https://doaj.org/article/2cf00ba41d244a9caba9210bb644349d
Autor:
Maria Tsagiopoulou, Ivo G. Gut
Publikováno v:
Frontiers in Genetics, Vol 14 (2024)
Chronic lymphocytic leukemia is a complex and heterogeneous hematological malignancy. The advance of high-throughput multi-omics technologies has significantly influenced chronic lymphocytic leukemia research and paved the way for precision medicine
Externí odkaz:
https://doaj.org/article/509c7242fc2f4d4599cb3d89bebdde40