Zobrazeno 1 - 10 of 34 pro vyhledávání: '"Ivo Frydrych"'
1
Akademický článek
Cell cycle profiling by image and flow cytometry: The optimised protocol for the detection of replicational activity using 5-Bromo-2'-deoxyuridine, low concentration of hydrochloric acid and exonuclease III.
Autor: Anna Ligasová, Petr Konečný, Ivo Frydrych, Karel Koberna
Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175880 (2017)
The approach for the detection of replicational activity in cells using 5-bromo-2'-deoxyuridine, a low concentration of hydrochloric acid and exonuclease III is presented in the study. The described method was optimised with the aim to provide a fast
Externí odkaz: https://doaj.org/article/551d6663665247ff90e74925fa47dc0f
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2
Akademický článek
Looking for ugly ducklings: The role of the stability of BrdU-antibody complex and the improved method of the detection of DNA replication.
Autor: Anna Ligasová, Petr Konečný, Ivo Frydrych, Karel Koberna
Publikováno v: PLoS ONE, Vol 12, Iss 3, p e0174893 (2017)
5-Bromo-2'-deoxyuridine (BrdU) labelling and immunostaining is commonly used for the detection of DNA replication using specific antibodies. Previously, we found that these antibodies significantly differ in their affinity to BrdU. Our present data s
Externí odkaz: https://doaj.org/article/50974e23930947d9a3c4b56cf2c68e11
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4
Triterpenoid pyrazines and pyridines - Synthesis, cytotoxicity, mechanism of action, preparation of prodrugs
Autor: Jiří Hodoň, Ivo Frydrych, Zdeňka Trhlíková, Jan Pokorný, Lucie Borková, Sandra Benická, Martin Vlk, Barbora Lišková, Agáta Kubíčková, Martina Medvedíková, Martin Pisár, Jan Šarek, Viswanath Das, Anna Ligasová, Karel Koberna, Petr Džubák, Marián Hajdúch, Milan Urban
Publikováno v: European journal of medicinal chemistry. 243
A set of fifteen triterpenoid pyrazines and pyridines was prepared from parent triterpenoid 3-oxoderivatives (betulonic acid, dihydrobetulonic acid, oleanonic acid, moronic acid, ursonic acid, heterobetulonic acid, and allobetulone). Cytotoxicity of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ac86c8ad10d87acca5c19bd417f0f70
https://pubmed.ncbi.nlm.nih.gov/36174412
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5
Abstract 2329: Disulfiram metabolite modulates NK and T cell cytotoxicity against metastatic colorectal cancer through tumor derived NKG2D ligands
Autor: Daciana Catalina Dumut, Ivo Frydrych, Miroslav Popper, Dusan Garic, Radu Alexandru Paun, Amanda Centorame, Olivia Canavan, Juhi Shah, Martin Mistrik, Petr Dzubak, Jiri Bartek, Marian Hajduch, Juan Bautista DeSanctis, Danuta Radzioch
Publikováno v: Cancer Research. 83:2329-2329
Introduction: Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, contributing to one million deaths yearly. While survival is expected in early-stage disease, the 5-year survival rate is only 15% in metastatic CRC
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b65cf0c63a583aa5e7f62c0108fe98a
https://doi.org/10.1158/1538-7445.am2023-2329
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7
Lupane derivatives containing various aryl substituents in the position 3 have selective cytostatic effect in leukemic cancer cells including resistant phenotypes
Autor: Lucie Borková, Ivo Frydrych, Barbora Vránová, Nikola Jakubcová, Barbora Lišková, Soňa Gurská, Petr Džubák, Petr Pavliš, Marián Hajdúch, Milan Urban
Publikováno v: European Journal of Medicinal Chemistry. 244:114850
In this work, a large set of betulinic acid derivatives modified with various aromatic substituents at the position C-3 were prepared via Suzuki-Myiaura cross-coupling. All compounds were tested for their in vitro cytotoxic activity in 8 cancer and 2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d70bb9ead9321b1d24a486bfbbcca6
https://doi.org/10.1016/j.ejmech.2022.114850
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8
Substituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters
Autor: Jan Pokorný, Ivo Frydrych, Jan Sarek, Barbora Liskova, Denisa Olejníková, Jana Kotulová, Soňa Gurská, Petr Džubák, Marian Hajduch, Milan Urban, Sandra Benická
Publikováno v: European Journal of Medicinal Chemistry. 224:113706
A set of new substituted dienes were synthesized from betulinic acid by its oxidation to 30-oxobetulinic acid followed by the Wittig reaction. Cytotoxicity of all compounds was tested in vitro in eight cancer cell lines and two noncancer fibroblasts.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d8a954af52ac90a45b3ca6cb94ce42
https://doi.org/10.1016/j.ejmech.2021.113706
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9
Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity
Autor: Pavel Drašar, Milan Kolář, Ivo Frydrych, Silvie Rimpelová, Kateřina Bogdanová, Soňa Gurská, Juraj Harmatha, Petr Konečný, Petr Džubák, Tomas Muller, Michal Jurášek, Marian Hajduch, David Sedlák, Eva Kmoníčková, Tomáš Ruml
Publikováno v: Steroids. 117:97-104
Sesquiterpene lactone trilobolide is a sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor, thus depleting the Ins(1,4,5)P3-sensitive intracellular calcium stores. Here, we describe a synthesis of a series of 6 trilobolide-steroids conjugates (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1712e1e197464d6ac07f88f5b5193ece
https://doi.org/10.1016/j.steroids.2016.08.011
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