Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Ivo C Lorenz"'
Autor:
Jaap Jan Boelens, Renier J Brentjens, Young Park, Ruby Freeman, Sanam Shahid, Abdul G Khan, Serena C Mathew, Sydney Souness, Erin R Burns, Jasmine S Um, Kento Tanaka, Winson Cai, Sarah Yoo, Andrew Dunbar, Devin McAvoy, Kinga K Hosszu, Ross L Levine, Ivo C Lorenz, Anthony F Daniyan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 5 (2024)
Background CD33 is a tractable target in acute myeloid leukemia (AML) for chimeric antigen receptor (CAR) T cell therapy, but clinical success is lacking.Methods We developed 3P14HLh28Z, a novel CD33-directed CD28/CD3Z-based CAR T cell derived from a
Externí odkaz:
https://doaj.org/article/b42d94a937d841e2987bd9a5c7486879
Autor:
Tao Dao, Sungsoo Mun, Tatyana Korontsvit, Abdul G Khan, Mary Ann Pohl, Thomas White, Martin G Klatt, David Andrew, Ivo C Lorenz, David A Scheinberg
Publikováno v:
PLoS ONE, Vol 17, Iss 3, p e0265534 (2022)
More effective treatments are needed for human papilloma virus (HPV)-induced cancers despite HPV virus vaccination. The oncogenic HPV protein targets are currently undruggable and intracellular and therefore there are no antibodies to these targets.
Externí odkaz:
https://doaj.org/article/a60ac414916d4580b7f762357ae31ad3
Autor:
Adam Biddlecome, Habtom H Habte, Katherine M McGrath, Sharmila Sambanthamoorthy, Melanie Wurm, Martina M Sykora, Charles M Knobler, Ivo C Lorenz, Marcio Lasaro, Knut Elbers, William M Gelbart
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0215031 (2019)
Many mRNA-based vaccines have been investigated for their specific potential to activate dendritic cells (DCs), the highly-specialized antigen-presenting cells of the immune system that play a key role in inducing effective CD4+ and CD8+ T-cell respo
Externí odkaz:
https://doaj.org/article/63ad183a4d8846fdaac630f59f825b51
Autor:
Della White, Alexandra Cote-Martin, Marina Bleck, Nicole Garaffa, Abdulsalam Shaaban, Helen Wu, Dongmei Liu, David Young, Justin Scheer, Ivo C. Lorenz, Andrew Nixon, Jay S. Fine, Fergus R. Byrne, M.Lamine Mbow, Miguel E. Moreno-Garcia
Publikováno v:
Molecular Immunology. 156:31-38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::388c96d47cd24c46a48d3821afd019c6
https://doi.org/10.1016/j.molimm.2023.02.007
https://doi.org/10.1016/j.molimm.2023.02.007
Autor:
Fengwen Zhang, Jesse Jenkins, Renan V.H. de Carvalho, Sandra Nakandakari-Higa, Teresia Chen, Morgan E. Abernathy, Elisabeth Nyakatura, David Andrew, Irina Lebedeva, Ivo C Lorenz, H.-Heinrich Hoffmann, Charles M. Rice, Gabriel D. Victora, Christopher O. Barnes, Theodora Haziioannou, Paul D. Bieniasz
Human monoclonal antibodies from convalescent individuals that target the SARS-CoV-2 spike protein have been deployed as therapeutics against SARS-CoV-2. However, nearly all of these antibodies have been rendered obsolete by SARS-CoV-2 variants that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bd16bb24bc0f5aef002299db4ff456a
https://doi.org/10.1101/2022.08.24.505169
https://doi.org/10.1101/2022.08.24.505169
Autor:
Markus Zettl, Melanie Wurm, Otmar Schaaf, Sven Mostböck, Iñigo Tirapu, Ilse Apfler, Ivo C. Lorenz, Lee Frego, Cynthia Kenny, Michael Thibodeau, Elisa Oquendo Cifuentes, Markus Reschke, Jürgen Moll, Norbert Kraut, Anne Vogt, Jonathon D. Sedgwick, Irene C. Waizenegger
Publikováno v:
OncoImmunology. 11
Upregulation of inhibitory receptors, such as lymphocyte activation gene-3 (LAG-3), may limit the antitumor activity of therapeutic antibodies targeting the programmed cell death protein-1 (PD-1) pathway. We describe the binding properties of ezabenl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d5955da139f178655722d2e414edb7d
https://doi.org/10.1080/2162402x.2022.2080328
https://doi.org/10.1080/2162402x.2022.2080328
Autor:
Erik Wennerberg, Sumit Mukherjee, Sheila Spada, Clarey Hung, Christopher J. Agrusa, Chuang Chen, Amanda Valeta-Magara, Nils-Petter Rudqvist, Samantha J. Van Nest, Mohamed K. Kamel, Abu Nasar, Navneet Narula, Vivek Mittal, Geoffrey J. Markowitz, Xi Kathy Zhou, Prasad S. Adusumilli, Alain C. Borczuk, Thomas E. White, Abdul G. Khan, Paul J. Balderes, Ivo C. Lorenz, Nasser Altorki, Sandra Demaria, Timothy E. McGraw, Brendon M. Stiles
Publikováno v:
Sci Transl Med
Most patients with non–small cell lung cancer (NSCLC) do not achieve durable clinical responses from immune checkpoint inhibitors, suggesting the existence of additional resistance mechanisms. Nicotinamide adenine dinucleotide (NAD)–induced cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::806fcbf42bdd4fd9e52432c9715534bc
https://doi.org/10.1126/scitranslmed.abe8195
https://doi.org/10.1126/scitranslmed.abe8195
Autor:
Amy M, Tsou, Hiroshi, Yano, Christopher N, Parkhurst, Tanel, Mahlakõiv, Coco, Chu, Wen, Zhang, Zhengxiang, He, Katja J, Jarick, Connie, Zhong, Gregory G, Putzel, Mai, Hatazaki, Ivo C, Lorenz, David, Andrew, Paul, Balderes, Christoph S N, Klose, Sergio A, Lira, Ann M, Joseph
Publikováno v:
Nature. 611(7937)
Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example, a neuronal rheostat provides excitatory or inhibitory signals that control the functions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224534bc9007a36cfaa8613bcb9f7458
https://pubmed.ncbi.nlm.nih.gov/36323781
https://pubmed.ncbi.nlm.nih.gov/36323781
Autor:
Tao Dao, Sungsoo Mun, Tatyana Korontsvit, Abdul G. Khan, Mary Ann Pohl, Thomas White, Martin G. Klatt, David Andrew, Ivo C. Lorenz, David A. Scheinberg
Publikováno v:
PloS one. 17(3)
More effective treatments are needed for human papilloma virus (HPV)-induced cancers despite HPV virus vaccination. The oncogenic HPV protein targets are currently undruggable and intracellular and therefore there are no antibodies to these targets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5141bed3ffce0ddbef11ca134e99aa
https://pubmed.ncbi.nlm.nih.gov/35298559
https://pubmed.ncbi.nlm.nih.gov/35298559
Autor:
Tao Dao, Sung Soo Mun, Zaki Molvi, Tatyana Korontsvit, Martin G. Klatt, Abdul G. Khan, Elisabeth K. Nyakatura, Mary Ann Pohl, Thomas E. White, Paul J. Balderes, Ivo C. Lorenz, Richard J. O’Reilly, David A. Scheinberg
Publikováno v:
JCI insight. 7(5)
Phosphopeptides derived from dysregulated protein phosphorylation in cancer cells can be processed and presented by MHC class I and class II molecules and, therefore, represent an untapped class of tumor-specific antigens that could be used as widely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a441d34e5d9b3e9666f4127151a2a3
https://pubmed.ncbi.nlm.nih.gov/35260532
https://pubmed.ncbi.nlm.nih.gov/35260532