Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Ivo, Tews"'
Autor:
Jack Stubbs, Theo Hornsey, Niall Hanrahan, Luis Blay Esteban, Rachel Bolton, Martin Malý, Shibom Basu, Julien Orlans, Daniele de Sanctis, Jung-uk Shim, Patrick D. Shaw Stewart, Allen M. Orville, Ivo Tews, Jonathan West
Publikováno v:
IUCrJ, Vol 11, Iss 2, Pp 237-248 (2024)
Serial crystallography requires large numbers of microcrystals and robust strategies to rapidly apply substrates to initiate reactions in time-resolved studies. Here, we report the use of droplet miniaturization for the controlled production of unifo
Externí odkaz:
https://doaj.org/article/c195768e5720466ea37cb52c3fb1391d
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
The streptococcal enzymes IdeS and EndoS cleave IgG antibodies with exquisite substrate specificity, which has enabled their development as clinical and biotechnological tools. Here, the authors present crystal structures of both enzymes in complex w
Externí odkaz:
https://doaj.org/article/a78e2cdfa2034e009850d8a61d09e31e
Autor:
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M. E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C. F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kevin L. Weiss, Jonathan A. R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi, Michael A. Hough
Publikováno v:
IUCrJ, Vol 9, Iss 5, Pp 610-624 (2022)
Room-temperature macromolecular crystallography allows protein structures to be determined under close-to-physiological conditions, permits dynamic freedom in protein motions and enables time-resolved studies. In the case of metalloenzymes that are h
Externí odkaz:
https://doaj.org/article/288bb78b21864584a71fa98e261fa74e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d. iNKT cells exhibit potent anti-tumour activity through direct killing mech
Externí odkaz:
https://doaj.org/article/742393c1a913480293ed915ffaa2b8dc
Autor:
Franziska Heckel, Anna H. Turaj, Hayden Fisher, H. T. Claude Chan, Michael J. E. Marshall, Osman Dadas, Christine A. Penfold, Tatyana Inzhelevskaya, C. Ian Mockridge, Diego Alvarado, Ivo Tews, Tibor Keler, Stephen A. Beers, Mark S. Cragg, Sean H. Lim
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.
Externí odkaz:
https://doaj.org/article/f7e2de2c168f4f2984754369dc482291
Autor:
Selina L. S. Storm, Adam D. Crawshaw, Nicholas E. Devenish, Rachel Bolton, David R. Hall, Ivo Tews, Gwyndaf Evans
Publikováno v:
IUCrJ, Vol 7, Iss 1, Pp 129-135 (2020)
With the increasing trend of using microcrystals and intense microbeams at synchrotron X-ray beamlines, radiation damage becomes a more pressing problem. Theoretical calculations show that the photoelectrons that primarily cause damage can escape mic
Externí odkaz:
https://doaj.org/article/c9779ef7021345f898d81a2c6eb36fac
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT PAS domains are omnipresent building blocks of multidomain proteins in all domains of life. Bacteria possess a variety of PAS domains in intracellular proteins and the related Cache domains in periplasmic or extracellular proteins. PAS and C
Externí odkaz:
https://doaj.org/article/a6f54646078c4473b310f10c53baed27
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Abstract The Gram-negative anaerobic bacterium Dichelobacter nodosus (Dn) causes footrot in ruminants, a debilitating and highly contagious disease that results in necrotic hooves and significant economic losses in agriculture. Vaccination with crude
Externí odkaz:
https://doaj.org/article/8d12f20ae8c141db8b95511b40c614ca
Autor:
Muchaala Yeboah, Charys Papagregoriou, Des C. Jones, H.T. Claude Chan, Guangan Hu, Justine S. McPartlan, Torbjörn Schiött, Ulrika Mattson, C. Ian Mockridge, Ulla-Carin Tornberg, Björn Hambe, Anne Ljungars, Mikael Mattsson, Ivo Tews, Martin J. Glennie, Stephen M. Thirdborough, John Trowsdale, Björn Frendeus, Jianzhu Chen, Mark S. Cragg, Ali Roghanian
Publikováno v:
JCI Insight, Vol 5, Iss 18 (2020)
Despite advances in identifying the key immunoregulatory roles of many of the human leukocyte immunoglobulin-like receptor (LILR) family members, the function of the inhibitory molecule LILRB3 (ILT5, CD85a, LIR3) remains unclear. Studies indicate a p
Externí odkaz:
https://doaj.org/article/90cb438ae1ab42bbb9e4805195e6e841
Autor:
Rachel Bolton, Moritz M. Machelett, Jack Stubbs, Danny Axford, Nicolas Caramello, Lucrezia Catapano, Martin Malý, Matthew J. Rodrigues, Charlotte Cordery, Graham J. Tizzard, Fraser MacMillan, Sylvain Engilberge, David von Stetten, Takehiko Tosha, Hiroshi Sugimoto, Jonathan A.R. Worrall, Jeremy S. Webb, Mike Zubkov, Simon Coles, Eric Mathieu, Roberto A. Steiner, Garib Murshudov, Tobias E. Schrader, Allen M. Orville, Antoine Royant, Gwyndaf Evans, Michael A. Hough, Robin L. Owen, Ivo Tews
The marine cyanobacteriumProchlorococcusis a main contributor to global photosynthesis, whilst being limited by iron availability. Cyanobacterial genomes typically encode two different types of FutA iron binding proteins: periplasmic FutA2 ABC transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1b7531313669316f8de3cadce45f50
https://doi.org/10.1101/2023.05.23.541926
https://doi.org/10.1101/2023.05.23.541926
