Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ivin S. Silver"'
Autor:
Earl G. Alley, William H. Benson, William O. Berndt, Thomas W. Bouldin, Alan Brimfield, Leslee D. Brown, Lewis R. Brown, Jerry Browne, Philip Carl, Franklin R. Champlin, Howard Chambers, Janice E. Chambers, Lorris G. Cockerham, Robert K. Collins, Sue Conly-Danehower, Jon C. Cook, Nancy M. Cox, Kevin M. Crofton, Walter C. Dauterman, Walter J. Diehl, Donald N. Downer, Laurence Fishbein, Joyce E. Goldstein, Frank E. Guthrie, Doyle Graham, Raymond E. Grissom, John E. Harkness, Ernest Hodgson, Mary E. Hodgson, Clinton D. Kilts, Renate D. Kimbrough, Steven Kinsler, John S. Kizer, Cindy P. Lawler, Ross B. Leidy, Ann T. Lemley, Patricia E. Levi, Margaret Lewandowski, Mark H. Lewis, Kim E. Light, Morris A. Lipton, Richard B. Mailman, Beth Mileson, Pierre Morell, Toshio Narahashi, David E. Nichols, Deborah L. Novicki, Jerome J. Perry, Mario Perez-Reyes, Gary Peterson, Stephen B. Pruett, T. Wayne Schultz, Tony M. Shih, Ivin S. Silver, Gary Smith, Ronald E. Tynes, Mary Vore, Charles A. Waggoner, Quentin D. Walker, William Wargin, Charles L. Wax, John H. Weisburger, Christopher F. Wilkinson, Gary M. Williams, Dwayne A. Wise, John F. Young
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::709b8e81cfdacfdc90944b9024083d13
https://doi.org/10.1016/b978-0-12-420169-9.00033-3
https://doi.org/10.1016/b978-0-12-420169-9.00033-3
Autor:
Richard A. Graham, Edward L. LeCluyse, Philip Clark, Wojciech L. Krol, Liangfu Chen, Troy T. Banks, Lindsey O. Tyler, Ivin S. Silver, Lindsey O. Webster
Publikováno v:
Journal of Biochemical and Molecular Toxicology. 20:69-78
Compared to other species, little information is available on the xenobiotic-induced regulation of cytochrome P450 enzymes in the beagle dog. Dogs are widely used in the pharmaceutical industry for many study types, including those that will impact d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485698b82707f305eebc79837de354fa
https://doi.org/10.1002/jbt.20118
https://doi.org/10.1002/jbt.20118
Autor:
Cornelia M. Smith, Edward L. LeCluyse, Masahiko Negishi, Wojciech L. Krol, Richard A. Graham, Hongbing Wang, Ivin S. Silver
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 315:1256-1264
Chrysin, a dietary flavonoid, has been shown to markedly induce UGT1A1 expression and activity in HepG2 and Caco-2 cell lines; thus, it has been suggested to have clinical utility in the treatment of UGT1A1-mediated deficiencies, such as unconjugated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dba9a1cc484f9061e9fc3f83a74c58b
https://doi.org/10.1124/jpet.105.090795
https://doi.org/10.1124/jpet.105.090795
Publikováno v:
Journal of Liquid Chromatography & Related Technologies. 19:1117-1126
A sensitive and selective high performance liquid chromatographic assay using UV-detection was developed for the analysis of 403U76, a structurally novel serotonin reuptake inhibitor, and two demethylated metabolites, 515U88 and 336U76 in rat plasma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db2d3ff2c1ab1a69d038e4dbd4fb8145
https://doi.org/10.1080/10826079608006306
https://doi.org/10.1080/10826079608006306
Publikováno v:
Tetrahedron Letters. 35:4919-4922
The structure of the epoxide of 1-ethyl-phenoxathiin 10,10-dioxide, a potential monoamine oxidase-A inhibitor, was elucidated using a combination of 500 MHz homo- and heteronuclear NMR techniques. The proton reference spectrum and a COSY spectrum wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ce707c55fd37ab42943d856b317011
https://doi.org/10.1016/s0040-4039(00)73282-5
https://doi.org/10.1016/s0040-4039(00)73282-5
Publikováno v:
Current topics in medicinal chemistry. 3(11)
Drug discovery is a long, arduous process broadly grouped into disease target identification, target validation, high-throughput identification of "hits" and "leads", lead optimization, and pre-clinical and clinical evaluation. Each area is a vast di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ac6ba6f45ba8e84e54d9d4a1256080
https://pubmed.ncbi.nlm.nih.gov/12769701
https://pubmed.ncbi.nlm.nih.gov/12769701
Publikováno v:
Methods in enzymology. 357
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2af16a7a7b964b1d88c345b81bbb234
https://pubmed.ncbi.nlm.nih.gov/12424918
https://pubmed.ncbi.nlm.nih.gov/12424918
Publisher Summary This chapter presents the automated and bio-analytical procedures used; the design criteria selected as being most important for high-throughput assays using enzymes from either single or multiple species; data that demonstrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e2f57b22880536fd83959ff8af88ce3
https://doi.org/10.1016/s0076-6879(02)57686-2
https://doi.org/10.1016/s0076-6879(02)57686-2
Autor:
John P. Shockcor, John C. Lindon, Robert M. Wurm, Paul N. Sanderson, R. D. Farrant, B. C. Sweatman, Ivin S. Silver
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 26(1)
1. The metabolism of 1-ethylphenoxathiin-10,10-dioxide (BW1370U87), an experimental compound designed as an inhibitor of monoamine oxidase-A for use as a possible anti-depression agent, has been studied in a human liver microsome preparation. 2. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ae12238fe82474dde828a2908328f4
https://pubmed.ncbi.nlm.nih.gov/8851820
https://pubmed.ncbi.nlm.nih.gov/8851820