Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Iveta Gažová"'
Autor:
Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Rocio Rojo, David A. Hume, Andreas Lengeling, Kim M. Summers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
USP16 is a histone deubiquitinase which facilitates G2/M transition during the cell cycle, regulates DNA damage repair and contributes to inducible gene expression. We mutated the USP16 gene in a high differentiation clone of the acute monocytic leuk
Externí odkaz:
https://doaj.org/article/007df63a40774d17a153ba289c1c7a34
Autor:
Iveta Gažová, Lucas Lefevre, Stephen J. Bush, Sara Clohisey, Erik Arner, Michiel de Hoon, Jessica Severin, Lucas van Duin, Robin Andersson, Andreas Lengeling, David A. Hume, Kim M. Summers
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely studied to test candidate leukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed Cap Ana
Externí odkaz:
https://doaj.org/article/7200a6989408462ca37702c78fd14d54
Autor:
Kim M. Summers, Iveta Gažová, David A. Hume, Rocio Rojo, Lucas Lefevre, Andreas Lengeling, Stephen J. Bush
Publikováno v:
Gažová, I, Lefevre, L, Bush, S J, Rojo, R, Hume, D A, Lengeling, A & Summers, K M 2021, ' CRISPR-Cas9 Editing of Human Histone Deubiquitinase Gene USP16 in Human Monocytic Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology, vol. 9, 679544 . https://doi.org/10.3389/fcell.2021.679544
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
USP16 is a histone deubiquitinase which facilitates G2/M transition during the cell cycle, regulates DNA damage repair and contributes to inducible gene expression. We mutated the USP16 gene in a high differentiation clone of the acute monocytic leuk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a95eb9751edbab94851bfe319002edc
https://www.pure.ed.ac.uk/ws/files/216120720/fcell_09_679544.pdf
https://www.pure.ed.ac.uk/ws/files/216120720/fcell_09_679544.pdf
Autor:
Lucas Lefevre, Kim M. Summers, Iveta Gažová, Jessica Severin, Michiel J. L. de Hoon, Andreas Lengeling, David A. Hume, Stephen J. Bush, Sara Clohisey, Erik Arner, Robin Andersson, Lucas van Duin
Publikováno v:
Frontiers in Cell and Developmental Biology
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M, Severin, J, van Duin, L, Andersson, R, Lengeling, A, Hume, D A & Summers, K M 2020, ' The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology, vol. 8, 498 . https://doi.org/10.3389/fcell.2020.00498
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M J, Severin, J, Duin, L V, Andersson, R, Lengeling, A, Hume, D & Summers, K 2020, ' The Transcriptional Network that Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology . https://doi.org/10.3389/fcell.2020.00498
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M, Severin, J, van Duin, L, Andersson, R, Lengeling, A, Hume, D A & Summers, K M 2020, ' The Transcriptional Network That Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology, vol. 8, 498 . https://doi.org/10.3389/fcell.2020.00498
Gazova, I, Lefevre, L, Bush, S J, Clohisey, S, Arner, E, de Hoon, M J, Severin, J, Duin, L V, Andersson, R, Lengeling, A, Hume, D & Summers, K 2020, ' The Transcriptional Network that Controls Growth Arrest and Macrophage Differentiation in the Human Myeloid Leukemia Cell Line THP-1 ', Frontiers in Cell and Developmental Biology . https://doi.org/10.3389/fcell.2020.00498
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The response of the human acute myeloid leukemia cell line THP-1 to phorbol esters has been widely-studied to test candidateleukemia therapies and as a model of cell cycle arrest and monocyte-macrophage differentiation. Here we have employed CapAnaly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e9cae35368dec2aba93fafb4041bd8
https://pubmed.ncbi.nlm.nih.gov/32719792
https://pubmed.ncbi.nlm.nih.gov/32719792
Publikováno v:
Gazova, I, lengeling, A & Summers, K M 2019, ' Lysine demethylases KDM6A and UTY: the X and Y of histone demethylation ', Molecular Genetics and Metabolism . https://doi.org/10.1016/j.ymgme.2019.04.012
Histone demethylases remove transcriptional repressive marks from histones in the nucleus. KDM6A (also known as UTX) is a lysine demethylase which acts on the trimethylated lysine at position 27 in histone 3. The KDM6A gene is located on the X chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df41452e36b7b5a3f5343e0504389bf2
https://www.pure.ed.ac.uk/ws/files/87865483/Lysine_demethylases_KDM6A_and_UTY_the_X_and_Y_of_histone_demethylation.pdf
https://www.pure.ed.ac.uk/ws/files/87865483/Lysine_demethylases_KDM6A_and_UTY_the_X_and_Y_of_histone_demethylation.pdf
Autor:
Rocío Rojo, Anna Raper, Derya D. Ozdemir, Lucas Lefevre, Kathleen Grabert, Evi Wollscheid-Lengeling, Barry Bradford, Melanie Caruso, Iveta Gazova, Alejandra Sánchez, Zofia M. Lisowski, Joana Alves, Irene Molina-Gonzalez, Hayk Davtyan, Rebecca J. Lodge, James D. Glover, Robert Wallace, David A. D. Munro, Eyal David, Ido Amit, Véronique E. Miron, Josef Priller, Stephen J. Jenkins, Giles E. Hardingham, Mathew Blurton-Jones, Neil A. Mabbott, Kim M. Summers, Peter Hohenstein, David A. Hume, Clare Pridans
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
The lineage-specific receptor CSF1R controls macrophage development and homeostasis. Here the authors show that deletion of a conserved Csf1r enhancer (FIRE) selectively depletes brain microglia and resident macrophages in the epidermis, kidney, hear
Externí odkaz:
https://doaj.org/article/f7dcb1c551fc424bb8707e117d441d06
Autor:
Mazdak Salavati, Alex Caulton, Richard Clark, Iveta Gazova, Timothy P. L. Smith, Kim C. Worley, Noelle E. Cockett, Alan L. Archibald, Shannon M. Clarke, Brenda M. Murdoch, Emily L. Clark
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
The overall aim of the Ovine FAANG project is to provide a comprehensive annotation of the new highly contiguous sheep reference genome sequence (Oar rambouillet v1.0). Mapping of transcription start sites (TSS) is a key first step in understanding t
Externí odkaz:
https://doaj.org/article/3a6ecf0bd6104d318dfbb89109c64627