Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Iveta, Mrizova"'
Autor:
Radek Indra, David H. Phillips, Volker M. Arlt, Iveta Mrizova, Colin J. Henderson, Michaela Moserová, Klaus Kopka, Lindsay Reed, Heinz H. Schmeiser, František Bárta, Marie Stiborová, C. Roland Wolf
Publikováno v:
Archives of Toxicology
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a216efdfc1a564d9b4cf13894220ebe0
http://europepmc.org/articles/PMC5882632
http://europepmc.org/articles/PMC5882632
Autor:
Annette M. Krais, Eszter Nagy, Volker M. Arlt, David H. Phillips, Walter Meinl, Iveta Mrizova, Simone Florian, Amin Mirza, František Bárta, Maggie Liu, Hansruedi Glatt, Marlies Thomann, Heinz H. Schmeiser, Klaus Kopka, Meirion Richards, Marie Stiborová
Publikováno v:
Arlt, V M, Meinl, W, Florian, S, Nagy, E, Barta, F, Thomann, M, Mrizova, I, Krais, A M, Liu, M, Richards, M, Mirza, A, Kopka, K, Phillips, D H, Glatt, H, Stiborova, M & Schmeiser, H H 2017, ' Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone ', Archives of Toxicology, vol. 91, no. 4, pp. 1957-1975 . https://doi.org/10.1007/s00204-016-1808-6
Archives of Toxicology
Archives of Toxicology
Exposure to aristolochic acid (AA) causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN). Conflicting results have been found for the role of human sulfotransferase 1A1 (SULT1A1) contributing to the metabolic activation of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fdc183e5db200f968b9012fc2e83a4
https://doi.org/10.1007/s00204-016-1808-6
https://doi.org/10.1007/s00204-016-1808-6
Autor:
Lindsay, Reed, Radek, Indra, Iveta, Mrizova, Michaela, Moserova, Heinz H, Schmeiser, C Roland, Wolf, Colin J, Henderson, Marie, Stiborova, David H, Phillips, Volker M, Arlt
Publikováno v:
Toxicology and Applied Pharmacology
The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b5 (Cyb5), electron donors to P45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42a932f7ed7e98bdf56ce268e20462b2
https://pubmed.ncbi.nlm.nih.gov/30685480
https://pubmed.ncbi.nlm.nih.gov/30685480
Autor:
Alexandra J, Willis, Radek, Indra, Laura E, Wohak, Osman, Sozeri, Kerstin, Feser, Iveta, Mrizova, David H, Phillips, Marie, Stiborova, Volker M, Arlt
Publikováno v:
Toxicology
Polycyclic aromatic hydrocarbons such as benzo[a]pyrene (BaP) can induce cytochrome P450 1A1 (CYP1A1) via a p53-dependent mechanism. The effect of different p53-activating chemotherapeutic drugs on CYP1A1 expression, and the resultant effect on BaP m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::572514d5c8a24ad197f2aa390808bbc5
https://pubmed.ncbi.nlm.nih.gov/29471073
https://pubmed.ncbi.nlm.nih.gov/29471073
Publikováno v:
Stiborová, M, Černá, V, Moserová, M, Mrízová, I, Arlt, V M & Frei, E 2015, ' The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies : Studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes ', International Journal of Molecular Sciences, vol. 16, no. 1, pp. 284-306 . https://doi.org/10.3390/ijms16010284
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 284-306 (2014)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 1, Pp 284-306 (2014)
International Journal of Molecular Sciences
Ellipticine is a DNA-damaging agent acting as a prodrug whose pharmacological efficiencies and genotoxic side effects are dictated by activation with cytochrome P450 (CYP). Over the last decade we have gained extensive experience in using pure enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228e7c3272d2546f0cbd35d30993e837
https://doi.org/10.3390/ijms16010284
https://doi.org/10.3390/ijms16010284
Autor:
Miroslav, Sulc, Iveta, Mrizova, Tereza, Cerna, Eva, Frei, Tomas, Eckschlager, Vojtech, Adam, Katerina, Kopeckova, Marie, Stiborova
Publikováno v:
Neuro endocrinology letters. 37(Suppl1)
Ellipticine is an anticancer agent that functions through multiple mechanisms participating in cell cycle arrest and initiation of apoptosis. This drug forms covalent DNA adducts after its enzymatic activation with cytochrome P450 (CYP), which is one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2ea2b59cbbec3b4c39dfec3f26264aba
https://pubmed.ncbi.nlm.nih.gov/28263536
https://pubmed.ncbi.nlm.nih.gov/28263536
Autor:
Petr, Hodek, Johana, Hrdinova, Iva, Macova, Pavel, Soucek, Iveta, Mrizova, Kamila, Burdova, Rene, Kizek, Jiri, Hudecek, Marie, Stiborova
Publikováno v:
Neuro endocrinology letters. 36
Cytochromes P450 (CYP) are monooxygenases, which metabolize mostly hydrophobic endogenous and exogenous compounds. CYPs without any clear connection to metabolism are called "orphans". Interestingly, these "orphan" CYPs are over-expressed in tumor ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46e231c0ffb4bd15994649ae520902df
https://pubmed.ncbi.nlm.nih.gov/26757124
https://pubmed.ncbi.nlm.nih.gov/26757124
Autor:
Iveta Mrizova, Marie Stiborová, Helena Dračínská, L. Bořek Dohalská, J. Holecová, Z. Klusoňová, Tomáš Cajthaml
Publikováno v:
Toxicology Letters. 258:S225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81e9535ab27829470167439bee6c0683
https://doi.org/10.1016/j.toxlet.2016.06.1808
https://doi.org/10.1016/j.toxlet.2016.06.1808
Autor:
Iveta Mrizova, Eva Frei, Helena Dračínská, Volker M. Arlt, Michaela Moserová, Marie Stiborová
Publikováno v:
Toxicology Letters. 229:S151
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d672bd1e4de39864a1153ded07a80f7
https://doi.org/10.1016/j.toxlet.2014.06.530
https://doi.org/10.1016/j.toxlet.2014.06.530