Výsledky vyhledávání - "Iveta, Hanzlíková"

Novel aminoarylcysteine adducts in globin of rats dosed with naphthylamine and nitronaphthalene isomers

Autor: Hana Vachová, Monika Tvrdíková, Šárka Dušková, Jaroslav Mráz, Iveta Hanzlíková, Igor Linhart

Publikováno v: Archives of toxicology. 95(1)

Novel aminonaphthylcysteine (ANC) adducts, formed via naphthylnitrenium ions and/or their metabolic precursors in the biotransformation of naphthylamines (NA) and nitronaphthalenes (NN), were identified and quantified in globin of rats dosed intraper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a1fabf1496f3cc4bd210ce30c80512
https://pubmed.ncbi.nlm.nih.gov/33156369

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N-(2-Hydroxyethyl)-l-valyl-l-leucine in rat urine as a hydrolytic cleavage product of ethylene oxide adduct with globin

Autor: Igor Linhart, Iveta Hanzlíková, Kamil Hejl, Šárka Dušková, Jaroslav Mráz, Ludmila Dabrowská

Publikováno v: Archives of Toxicology. 93:603-613

Ethylene oxide (EO), a genotoxic industrial chemical and sterilant, forms covalent adducts with DNA and also with nucleophilic amino acids in proteins. The adduct with N-terminal valine in globin [N-(2-hydroxyethyl)valine (HEV)] has been used in biom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1622b2ce61168cdf1dd333757e082b5f
https://doi.org/10.1007/s00204-019-02388-8

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Determination of N-(2-hydroxyethyl)valine in globin of ethylene oxide-exposed workers using total acidic hydrolysis and HPLC–ESI–MS2

Autor: Hana Chrástecká, Igor Linhart, Iveta Hanzlíková, Šárka Dušková, Jaroslav Mráz, Radka Vajtrová, Monika Tvrdíková

Publikováno v: Toxicology Letters. 298:76-80

Ethylene oxide (EO), an industrial intermediate and gaseous sterilant for medical devices, is carcinogenic to humans, which warrants minimization of exposure in the workplaces. The principal analytical strategy currently used in biomonitoring of expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ae2e716b0fbe90fbb69660ec216f790
https://doi.org/10.1016/j.toxlet.2018.06.1212

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S-(3-Aminobenzanthron-2-yl)cysteine in the globin of rats as a novel type of adduct and possible biomarker of exposure to 3-nitrobenzanthrone, a potent environmental carcinogen

Autor: Igor Linhart, Iveta Hanzlíková, Jaroslav Mráz, Šárka Dušková

Publikováno v: Archives of Toxicology. 91:3317-3325

3-Nitrobenzanthrone (3-NBA), a potent environmental mutagen and carcinogen, is known to be activated in vivo to 3-benzanthronylnitrenium ion which forms both NH and C2-bound adducts with DNA and also reacts with glutathione giving rise to urinary 3-a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa0e795f617ec44499f5b0b7825379c
https://doi.org/10.1007/s00204-017-1943-8

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N-(2-Hydroxyethyl)-l-valyl-l-leucine: a novel urinary biomarker of ethylene oxide exposure in humans

Autor: Šárka Dušková, Jaroslav Mráz, Monika Tvrdíková, Igor Linhart, Iveta Hanzlíková

Publikováno v: Toxicology letters. 326

Ethylene oxide (EO), a carcinogenic chemical used as an industrial intermediate and sterilant, forms covalent adducts with DNA and proteins. The adduct with N-terminal valine [N-(2-hydroxyethyl)- l -valine, HEV] in blood protein globin has been emplo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6300f558344d57f01a97ad6fad82173d
https://pubmed.ncbi.nlm.nih.gov/32145395

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