Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Ivet, Bahar"'
Publikováno v:
eLife, Vol 12 (2024)
The vesicular monoamine transporter 2 (VMAT2) is a proton-dependent antiporter responsible for loading monoamine neurotransmitters into synaptic vesicles. Dysregulation of VMAT2 can lead to several neuropsychiatric disorders including Parkinson’s d
Externí odkaz:
https://doaj.org/article/393c81c8a92d464781df40f53e029e46
Autor:
Hoang Nguyen, Mary Hongying Cheng, Ji Young Lee, Shaili Aggarwal, Ole Valente Mortensen, Ivet Bahar
Publikováno v:
Current Research in Physiology, Vol 7, Iss , Pp 100125- (2024)
Human monoamine transporters (MATs) are critical to regulating monoaminergic neurotransmission by translocating their substrates from the synaptic space back into the presynaptic neurons. As such, their primary substrate binding site S1 has been targ
Externí odkaz:
https://doaj.org/article/2dd442ed5c1e4971947f9e308ab3fdf1
Autor:
Xuan Zhang, Tina Weiß, Mary Hongying Cheng, Siqi Chen, Carla Katharina Ambrosius, Anne Sophie Czerniak, Kunpeng Li, Mingye Feng, Ivet Bahar, Annette G Beck-Sickinger, Cheng Zhang
Publikováno v:
PLoS Biology, Vol 21, Iss 12, p e3002188 (2023)
Chemokine-like receptor 1 (CMKLR1), also known as chemerin receptor 23 (ChemR23) or chemerin receptor 1, is a chemoattractant G protein-coupled receptor (GPCR) that responds to the adipokine chemerin and is highly expressed in innate immune cells, in
Externí odkaz:
https://doaj.org/article/3564aaff35224cb3be106e5a8988ac7e
Autor:
Veerpal Kaur, Demelza Wright, Samuel Mathew, Matthew Peters, Maria Zacharopoulou, Shang Hua Yang, Laura S Itzhaki, Ivet Bahar, Reuven Gordon
Publikováno v:
JPhys Photonics, Vol 6, Iss 3, p 035023 (2024)
We demonstrate the trapping and analysis of individual proteins using a portable optical fiber tweezer setup with a double-nanohole in a gold film coating the fiber’s end and aligned with the fiber core. The instrument was used to trap and analyze
Externí odkaz:
https://doaj.org/article/b04ba492cd294334b1d0d580f7115d7e
Autor:
David Herreros, Roy R. Lederman, James Krieger, Amaya Jiménez-Moreno, Marta Martínez, David Myška, David Strelak, Jiri Filipovic, Ivet Bahar, Jose Maria Carazo, Carlos Oscar S. Sanchez
Publikováno v:
IUCrJ, Vol 8, Iss 6, Pp 992-1005 (2021)
Structural biology has evolved greatly due to the advances introduced in fields like electron microscopy. This image-capturing technique, combined with improved algorithms and current data processing software, allows the recovery of different conform
Externí odkaz:
https://doaj.org/article/67b272f266e3477db975106481fc43d1
Autor:
Fangyuan Chen, Qingya Shi, Fen Pei, Andreas Vogt, Rebecca A Porritt, Gustavo Garcia, Angela C Gomez, Mary Hongying Cheng, Mark E Schurdak, Bing Liu, Stephen Y Chan, Vaithilingaraja Arumugaswami, Andrew M Stern, D Lansing Taylor, Moshe Arditi, Ivet Bahar
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 8, Pp 1-23 (2021)
Abstract Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential therapeutics are global imperatives. Using a quantitative systems pharmacology approach, we identified a set of repurposable and investigational drugs as poten
Externí odkaz:
https://doaj.org/article/7db43c04a84b4afb9367c079ed650876
Autor:
Chuan Chen, James W. Saville, Michelle M. Marti, Alexandra Schäfer, Mary Hongying Cheng, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Anupam Banerjee, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Nathan Enick, Kevin D. McCormick, Xianglei Liu, Cynthia Adams, Margaret Grace Hines, Zehua Sun, Weizao Chen, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Ralph S. Baric, Ivet Bahar, Dimiter S. Dimitrov, Sriram Subramaniam, David R. Martinez, Wei Li
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104798- (2022)
Summary: The emergence of SARS-CoV-2 variants of concern (VOCs) requires the development of next-generation biologics with high neutralization breadth. Here, we characterized a human VH domain, F6, which we generated by sequentially panning large pha
Externí odkaz:
https://doaj.org/article/e9a8e86720ca420e9915a6296aa53a18
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Multisystem inflammatory syndrome in children (MIS-C) is a febrile pediatric inflammatory disease that may develop weeks after initial SARS-CoV-2 infection or exposure. MIS-C involves systemic hyperinflammation and multiorgan involvement, including s
Externí odkaz:
https://doaj.org/article/9d2a1635c46e42da826cee9dd68e7261
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background In the last decade, Genome-wide Association studies (GWASs) have contributed to decoding the human genome by uncovering many genetic variations associated with various diseases. Many follow-up investigations involve joint analysis
Externí odkaz:
https://doaj.org/article/05f88af5de8346ee9b3ab5c68a330fd8
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-15 (2021)
Abstract In any ‘omics study, the scale of analysis can dramatically affect the outcome. For instance, when clustering single-cell transcriptomes, is the analysis tuned to discover broad or specific cell types? Likewise, protein communities reveale
Externí odkaz:
https://doaj.org/article/f2b38dc2db7d4aae9e73eee2d05d6b63