A phase 1b/2 study evaluating efficacy and safety of MP0250, a designed ankyrin repeat protein (DARPin) simultaneously targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), in combination with bortezomib and dexamethasone, in patients with relapsed or refractory multiple myeloma.

Autor: Knop S; Universitätsklinikum Würzburg Würzburg Germany., Szarejko M; Uniwersyteckie Centrum Kliniczne Gdansk Poland., Grząśko N; Department of Experimental Hematooncology Medical University of Lublin and Centrum Onkologii Ziemi Lubelskiej Lublin Poland., Bringhen S; SSD Clinical Trial in Oncoematologia e Myeloma, Dipartimento di Oncologia Azienda Ospedaliera-Universitaria Città della Salute e della Scienza di Torino Torino Italy., Trautmann-Grill K; Universitätsklinikum Dresden, Technische Universität Dresden Dresden Germany., Jurczyszyn A; Plasma Cell Dyscrasias Center, Department of Hematology Jagiellonian University Medical College Krakow Poland., Vacca A; Department of Precision and Regenerative Medicine and Ionian Area Unit of Medicina Interna 'Guido Baccelli' University of Bari Aldo Moro Azienda Policlinico Bari Italy., Khandanpour C; Universitätsklinikum Münster, Münster, Germany and University Hospital Schleswig-Holstein Campus Lübeck University Cancer Center Schleswig-Holstein, and University of Lübeck Lübeck Germany., Gamberi B; AUSL-IRCCS Reggio Emilia Reggio Emilia Italy., Pour L; Fakultní Nemocnice Brno Brno Czechia., Iversen KF; Lillebaelt Hospital Vejle Denmark., Stumpp MT; Molecular Partners AG Zurich-Schlieren Switzerland., Suter C; Molecular Partners AG Zurich-Schlieren Switzerland., Dawson KM; Molecular Partners AG Zurich-Schlieren Switzerland., Zitt C; Molecular Partners AG Zurich-Schlieren Switzerland., Legenne P; Molecular Partners AG Zurich-Schlieren Switzerland., Stavropoulou V; Molecular Partners AG Zurich-Schlieren Switzerland., Fey MF; Molecular Partners AG Zurich-Schlieren Switzerland., Leupin N; Molecular Partners AG Zurich-Schlieren Switzerland., Goldschmidt H; Medical Department V Universitätsklinikum Heidelberg Heidelberg Germany.

Publikováno v: EJHaem [EJHaem] 2024 Aug 01; Vol. 5 (5), pp. 940-950. Date of Electronic Publication: 2024 Aug 01 (Print Publication: 2024).

The real-world use and efficacy of pomalidomide for relapsed and refractory multiple myeloma in the era of CD38 antibodies.

Autor: Szabo AG; Department of Hematology Vejle Hospital Vejle Denmark.; Department of Hematology, Rigshospitalet Copenhagen University Copenhagen Denmark., Thorsen J; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital University of Copenhagen Copenhagen Denmark., Iversen KF; Department of Hematology Vejle Hospital Vejle Denmark., Levring MB; Department of Hematology Odense University Hospital Odense Denmark., Helleberg C; Department of Hematology, Rigshospitalet Copenhagen University Copenhagen Denmark., Hermansen E; Department of Hematology, Rigshospitalet Copenhagen University Copenhagen Denmark.; Department of Hematology Zealand University Hospital Roskilde Denmark., Bønløkke ST; Department of Hematology Aarhus University Hospital Aarhus Denmark., Nielsen K; Department of Hematology Aarhus University Hospital Aarhus Denmark., Teodorescu EM; Department of Hematology Aalborg University Hospital Aalborg Denmark., Kurt E; Department of Hematology Regionshospitalet Gødstrup Herning Denmark., Strandholdt CN; Department of Hematology Hospital of Southwest Jutland Esbjerg Denmark., Vangsted AJ; Department of Hematology, Rigshospitalet Copenhagen University Copenhagen Denmark.

Publikováno v: EJHaem [EJHaem] 2023 Aug 24; Vol. 4 (4), pp. 1006-1012. Date of Electronic Publication: 2023 Aug 24 (Print Publication: 2023).

High Expression of the Costimulatory Checkpoint Factor DNAM-1 by CD4 ⁺ T-Cells from Multiple Myeloma Patients Refractory to Daratumumab-Containing Regimens.

Autor: Iversen KF; Institute of Regional Health Science, University of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark. katrine.fladeland.iversen@rsyd.dk.; Section of Hematology, Department of Internal Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark. katrine.fladeland.iversen@rsyd.dk., Nederby L; Department of Biochemistry and Immunology, Lillebaelt Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark., Lund T; Department of Hematology, Odense University Hospital, J.B. Winsløvs Vej 4, 5000, Odense C, Denmark., Plesner T; Institute of Regional Health Science, University of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark.; Section of Hematology, Department of Internal Medicine, Lillebaelt Hospital, University Hospital of Southern Denmark, Beriderbakken 4, 7100, Vejle, Denmark.

Publikováno v: Clinical hematology international [Clin Hematol Int] 2022 Sep; Vol. 4 (3), pp. 107-116. Date of Electronic Publication: 2022 Aug 09.

The real-world outcomes of multiple myeloma patients treated with daratumumab.

Autor: Szabo AG; Department of Hematology, Vejle Hospital, Vejle, Denmark., Klausen TW; Department of Hematology, Herlev University Hospital, Herlev, Denmark., Levring MB; Department of Hematology, Odense University Hospital, Odense, Denmark., Preiss B; Department of Pathology, Odense University Hospital, Odense, Denmark., Helleberg C; Department of Hematology, Herlev University Hospital, Herlev, Denmark., Breinholt MF; Department of Pathology, Herlev University Hospital, Herlev, Denmark., Hermansen E; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Gjerdrum LMR; Department of Pathology, Zealand University Hospital, Roskilde, Denmark., Bønløkke ST; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., Nielsen K; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., Kjeldsen E; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., Iversen KF; Department of Hematology, Vejle Hospital, Vejle, Denmark., Teodorescu EM; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark., Dokhi M; Department of Hematology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark., Kurt E; Department of Hematology, Regionshospitalet Holstebro, Holstebro, Denmark., Strandholdt C; Department of Hematology, Esbjerg Hospital, Esbjerg, Denmark., Andersen MK; Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark., Vangsted AJ; Department of Hematology, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.

Publikováno v: PloS one [PLoS One] 2021 Oct 13; Vol. 16 (10), pp. e0258487. Date of Electronic Publication: 2021 Oct 13 (Print Publication: 2021).

Clinically-suspected cast nephropathy: A retrospective, national, real-world study.

Autor: Szabo AG; Department of Hematology, Vejle Hospital, Vejle and University of Southern Denmark, Vejle, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Thorsen J; Department of Hematology, Vejle Hospital, Vejle and University of Southern Denmark, Vejle, Denmark.; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Denmark., Iversen KF; Department of Hematology, Vejle Hospital, Vejle and University of Southern Denmark, Vejle, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Hansen CT; Department of Hematology, Odense University Hospital, Odense, Denmark., Teodorescu EM; Department of Hematology, Aalborg University Hospital, Aalborg, Denmark., Pedersen SB; Department of Hematology, Herlev University Hospital, Herlev, Denmark., Flaeng SB; Department of Hematology, Regional Hospital West Jutland, Holstebro, Denmark., Strandholdt C; Department of Hematology, Hospital of South West Jutland, Esbjerg, Denmark., Frederiksen M; Department of Hematology, Aabenraa Hospital, Aabenraa, Denmark., Vase MØ; Department of Hematology, Aarhus University Hospital, Aarhus, Denmark., Frølund UC; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Krustrup D; Department of Pathology, Herlev University Hospital, Herlev, Denmark., Plesner T; Department of Hematology, Vejle Hospital, Vejle and University of Southern Denmark, Vejle, Denmark.; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Vangsted AJ; Department of Hematology, Rigshospitalet, Copenhagen, Denmark.

Publikováno v: American journal of hematology [Am J Hematol] 2020 Nov; Vol. 95 (11), pp. 1352-1360. Date of Electronic Publication: 2020 Aug 26.