Possible footprints of APOBEC3F and/or other APOBEC3 deaminases, but not APOBEC3G, on HIV-1 from patients with acute/early and chronic infections

Autor: Andrew E. Armitage, John J. Welch, Andrew Rambaut, Iversen Akn., Koen Deforche, K. Van Laethem, Ricardo Jorge Camacho

Members of the apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like-3 (APOBEC3) innate cellular cytidine deaminase family, particularly APOBEC3F and APOBEC3G, can cause extensive and lethal G-to-A mutations in HIV-1 plus-strand DNA (termed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c9d50d1f1c87bc52970ba6f3cc8f8b
https://ora.ox.ac.uk/objects/uuid:e369fd57-1e3e-4082-bb0d-115eb0a09e6c

Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance

Autor: Anne Burgevin, Søren Buus, Mirjana Weimershaus, P van Endert, Hansjörg Schild, Mikkel Harndahl, Guillaume Stewart-Jones, Jan Gerstoft, Andrew J. McMichael, Kasper Lamberth, Paul Klenerman, L Friis, Nadja Akkad, Stefan Tenzer, Iversen Akn., E Y Jones, E Wee, Chang C-H., Lars Fugger

Publikováno v: Tenzer, S, Wee, E, Burgevin, A, Stewart-Jones, G, Friis, L, Lamberth, K, Chang, C-H, Harndahl, M, Weimershaus, M, Gerstoft, J, Akkad, N, Klenerman, P, Fugger, L, Jones, E Y, McMichael, A J, Buus, S, Schild, H, van Endert, P & Iversen, A K N 2009, ' Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance ', Nature Immunology, vol. 10, no. 6, pp. 636-46 . https://doi.org/10.1038/ni.1728
Nature Immunology; Vol 10

Udgivelsesdato: 2009-May-03 Although cytotoxic T lymphocytes (CTLs) in people infected with human immunodeficiency virus type 1 can potentially target multiple virus epitopes, the same few are recognized repeatedly. We show here that CTL immunodomina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d080244393af2c71d786eaa316801e3c
http://ora.ox.ac.uk/objects/uuid:8a2e9bae-d0d0-47a7-8424-c16c4f410c3a

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope

Autor: Tao Dong, Andrew J. McMichael, Lars Fugger, Peter Skinhøj, Kelly S. MacDonald, J K Lee, E Y Jones, N. Christie, P. Chotiyarnwong, Tara S Beattie, Iversen Akn., Andrew E. Armitage, Søren Buus, B. Klarlund-Pedersen, C. Sylvester-Hviid, P A van der Merwe, Henrik Ullum, Xinfang Xu, James I. Mullins, Mark A. Luscher, Gerald H. Learn, Rupert Kaul, Guillaume Stewart-Jones, Y. Li

Publikováno v: Nature immunology. 7(2)

Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immuno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e40c38b6ef1caedb2f5b1645507eab9
http://ora.ox.ac.uk/objects/uuid:7732bb1c-522c-4112-9937-3abb05a8b06e

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