Sarcoma classification by DNA methylation profiling

Autor: Christian Koelsche, Daniel Schrimpf, Damian Stichel, Martin Sill, Felix Sahm, David E. Reuss, Mirjam Blattner, Barbara Worst, Christoph E. Heilig, Katja Beck, Peter Horak, Simon Kreutzfeldt, Elke Paff, Sebastian Stark, Pascal Johann, Florian Selt, Jonas Ecker, Dominik Sturm, Kristian W. Pajtler, Annekathrin Reinhardt, Annika K. Wefers, Philipp Sievers, Azadeh Ebrahimi, Abigail Suwala, Francisco Fernández-Klett, Belén Casalini, Andrey Korshunov, Volker Hovestadt, Felix K. F. Kommoss, Mark Kriegsmann, Matthias Schick, Melanie Bewerunge-Hudler, Till Milde, Olaf Witt, Andreas E. Kulozik, Marcel Kool, Laura Romero-Pérez, Thomas G. P. Grünewald, Thomas Kirchner, Wolfgang Wick, Michael Platten, Andreas Unterberg, Matthias Uhl, Amir Abdollahi, Jürgen Debus, Burkhard Lehner, Christian Thomas, Martin Hasselblatt, Werner Paulus, Christian Hartmann, Ori Staszewski, Marco Prinz, Jürgen Hench, Stephan Frank, Yvonne M. H. Versleijen-Jonkers, Marije E. Weidema, Thomas Mentzel, Klaus Griewank, Enrique de Álava, Juan Díaz Martín, Miguel A. Idoate Gastearena, Kenneth Tou-En Chang, Sharon Yin Yee Low, Adrian Cuevas-Bourdier, Michel Mittelbronn, Martin Mynarek, Stefan Rutkowski, Ulrich Schüller, Viktor F. Mautner, Jens Schittenhelm, Jonathan Serrano, Matija Snuderl, Reinhard Büttner, Thomas Klingebiel, Rolf Buslei, Manfred Gessler, Pieter Wesseling, Winand N. M. Dinjens, Sebastian Brandner, Zane Jaunmuktane, Iben Lyskjær, Peter Schirmacher, Albrecht Stenzinger, Benedikt Brors, Hanno Glimm, Christoph Heining, Oscar M. Tirado, Miguel Sáinz-Jaspeado, Jaume Mora, Javier Alonso, Xavier Garcia del Muro, Sebastian Moran, Manel Esteller, Jamal K. Benhamida, Marc Ladanyi, Eva Wardelmann, Cristina Antonescu, Adrienne Flanagan, Uta Dirksen, Peter Hohenberger, Daniel Baumhoer, Wolfgang Hartmann, Christian Vokuhl, Uta Flucke, Iver Petersen, Gunhild Mechtersheimer, David Capper, David T. W. Jones, Stefan Fröhling, Stefan M. Pfister, Andreas von Deimling

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve c

Externí odkaz: https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b

Data from CD74–NRG1 Fusions in Lung Adenocarcinoma

Autor: Roman K. Thomas, Yasushi Yatabe, Stefan A. Haas, Sascha Ansén, Sven Perner, Jürgen Wolf, Thomas Zander, Reinhard Buettner, Lukas C. Heukamp, Martin Vingron, Dirk Brehmer, Marc Parade, Souichi Ogata, Timothy Perera, Idoya Lahortiga, Vito M. Fazio, Annamaria la Torre, Lucia A. Muscarella, Jörg Sänger, Joachim H. Clement, Iver Petersen, Erich Stoelben, Johannes M. Heuckmann, Peter Nürnberg, Christian Becker, Janine Altmüller, Sylvie Lantuejoul, Christian G. Brambilla, Denis Moro-Sibilot, Hélène Nagy-Mignotte, Elisabeth Brambilla, Benjamin Solomon, Zoe Wainer, Prudence A. Russell, Gavin M. Wright, Roland T. Ullrich, Mirjam Koker, Ilona Dahmen, Wenzel Vogel, Jakob Schöttle, Florian Malchers, Juliane Daßler, Marc Bos, Martin Peifer, Sandra Ortiz-Cuaran, Frauke Leenders, Roopika Menon, Ruping Sun, Hirotaka Osada, Dennis Plenker, Lynnette Fernandez-Cuesta

We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional fusion-positive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d4ae6f70c75968b34b2f3d7faa842ab
https://doi.org/10.1158/2159-8290.c.6546108

Interview with Dr. Meyerson from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Autor: Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman

mp3 file (6.8 MB). In the inaugural edition of the Cancer Discovery podcast, Executive Editor Mark Landis talks with Matthew Meyerson about his paper, which describes the identification of the DDR2 kinase as a therapeutic target in squamous cell lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e5addd2d5a8ac8b634e34fdba42185
https://doi.org/10.1158/2159-8290.22529081

Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Autor: Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman

Supplementary Table 1 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db13f0f0711315c79b59f97a73ae407
https://doi.org/10.1158/2159-8290.22529072

Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Autor: Matthew Meyerson, Roman K. Thomas, Eric B. Haura, Kwok-Kin Wong, Nathanael S. Gray, Daniel Rauh, Jeonghee Cho, Adam J. Bass, Heidi Greulich, Wendy Winckler, Bruce E. Johnson, Pasi A. Janne, Michael J. Eck, Charles Hatton, Megan Hanna, Ming Sound Tsao, David G. Beer, Jürgen Wolf, Erich Stoelben, Hannie Sietsma, Wim Timens, Harry Groen, Joachim H. Clement, Iver Petersen, Åslaug Helland, Odd Terje Brustugun, Philippe Lorimier, Christian Brambilla, Elisabeth Brambilla, Sascha Ansén, Silvia Querings, Franziska Gabler, Frauke Leenders, Mirjam Koker, Holger Moch, Alex Soltermann, Johannes M. Heuckmann, Thomas Zander, Danila Seidel, Helga B. Salvesen, Robert C. Onofrio, Michael S. Lawrence, Jeffrey R. Simard, Martin Peifer, Stefanie Heynck, Sang Min Lim, Xianming Deng, Jianming Zhang, Wenchu Lin, Brittany A. Woods, Lear E. Brace, Wenjun Zhou, Amit Dutt, Chunxiao Xu, Alex H. Ramos, Martin L. Sos, Peter S. Hammerman

Supplementary Figures 1-7 from Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531f85fe4c83a1a8d4a9016eb995d4c2
https://doi.org/10.1158/2159-8290.22529075.v1