Výsledky vyhledávání - "Ivayla, Ivanova"

Akademický článek

RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression

Autor: Stuart W. McKellar, Ivayla Ivanova, Pedro Arede, Rachel L. Zapf, Noémie Mercier, Liang-Cui Chu, Daniel G. Mediati, Amy C. Pickering, Paul Briaud, Robert G. Foster, Grzegorz Kudla, J. Ross Fitzgerald, Isabelle Caldelari, Ronan K. Carroll, Jai J. Tree, Sander Granneman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, McKellar et al. apply RNase IIICLASH of multi-drug resistant Staphylococcus aureus under different culture condi

Externí odkaz: https://doaj.org/article/5c83133778664f04bc823f94397e141e

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Akademický článek

The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins

Autor: Liang-Cui Chu, Pedro Arede, Wei Li, Erika C. Urdaneta, Ivayla Ivanova, Stuart W. McKellar, Jimi C. Wills, Theresa Fröhlich, Alexander von Kriegsheim, Benedikt M. Beckmann, Sander Granneman

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

RNA-binding proteins play key roles in controlling gene expression in many organisms. Here, Chu et al. identify hundreds of RNA-binding proteins in methicillin-resistant Staphylococcus aureus, and show that a major transcription factor uses its helix

Externí odkaz: https://doaj.org/article/f87797381ee945be8b0d419db2e0c750

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Akademický článek

NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells

Autor: Azzurra Codino, Tomasz Turowski, Louie N. van de Lagemaat, Ivayla Ivanova, Andrea Tavosanis, Christian Much, Tania Auchynnikava, Lina Vasiliauskaitė, Marcos Morgan, Juri Rappsilber, Robin C. Allshire, Kamil R. Kranc, David Tollervey, Dónal O'Carroll

Publikováno v: iScience, Vol 24, Iss 7, Pp 102762- (2021)

Summary: Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully un

Externí odkaz: https://doaj.org/article/c901871256cd489d8e9d27e417a6e14f

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NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells

Autor: Andrea Tavosanis, Robin C. Allshire, Tania Auchynnikava, Louie N. van de Lagemaat, David Tollervey, Juri Rappsilber, Kamil R. Kranc, Azzurra Codino, Marcos Morgan, Lina Vasiliauskaitė, Ivayla Ivanova, Tomasz W. Turowski, Dónal O'Carroll, Christian Much

Publikováno v: Codino, A, Turowski, T, Van De Lagemaat, L N, Ivanova, I, Tavosanis, A, Much, C, Auchynnikava, T, Vasiliauskaitė, L, Morgan, M, Rappsilber, J, Allshire, R C, Kranc, K R, Tollervey, D & O'carroll, D 2021, ' NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells ', iScience, vol. 24, no. 7, pp. 102762 . https://doi.org/10.1016/j.isci.2021.102762
iScience, Vol 24, Iss 7, Pp 102762-(2021)
iScience

Summary Spermatogonial stem cells (SSCs) sustain spermatogenesis and fertility throughout adult male life. The conserved RNA-binding protein NANOS2 is essential for the maintenance of SSCs, but its targets and mechanisms of function are not fully und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f0d604f36300b40fac0b9c874461a3
https://www.pure.ed.ac.uk/ws/files/222714014/PIIS2589004221007306.pdf

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A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

Autor: Ivayla Ivanova, Stefano Comazzetto, Bo T. Porse, Christian Much, Robin C. Allshire, Lina Vasiliauskaitė, Tatsiana Auchynnikava, Juri Rappsilber, Dimitrios Vitsios, Anton J. Enright, Jack M. Monahan, Marcos Morgan, Monica Di Giacomo, Dónal O'Carroll, Yuka Kabayama

Publikováno v: Morgan, M, Kabayama, Y, Much, C, Ivanova, I, Di Giacomo, M, Auchynnikava, T, Monahan, J M, Vitsios, D M, Vasiliauskaite, L, Comazzetto, S, Rappsilber, J, Allshire, R C, Porse, B T, Enright, A J & O'Carroll, D 2019, ' A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis ', Cell Research, vol. 29, pp. 221-232 . https://doi.org/10.1038/s41422-018-0128-1
Cell Research
Morgan, M, Kabayama, Y, Much, C, Ivanova, I, Di Giacomo, M, Auchynnikava, T, Monahan, J M, Vitsios, D M, Vasiliauskaitė, L, Comazzetto, S, Rappsilber, J, Allshire, R C, Porse, B T, Enright, A J & O'Carroll, D 2019, ' A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis ', Cell Research, pp. 221–232 . https://doi.org/10.1038/s41422-018-0128-1

Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transition is not only associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d33cc596cdd101c475d451dfac3008
https://doi.org/10.1038/s41422-018-0128-1

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The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function

Autor: Richard I. Gregory, Daniela S. Krause, Christopher Mapperley, Jun-Ho Choe, Christian Much, Alex von Kriegsheim, Dónal O'Carroll, Joana Campos, David Wotherspoon, Andrea Tavosanis, Adam J. Mead, Jozef Durko, Louie N. van de Lagemaat, Kamil R. Kranc, Annika Sarapuu, Jasmin Paris, Marcos Morgan, Ivayla Ivanova, Hannah Lawson

Publikováno v: Mapperley, C, Van De Lagemaat, L, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, von Kriegsheim, A, Much, C, Morgan, M, Gregory, R I, Mead, A J, O'Carroll, D & Kranc, K 2020, ' The mRNA m6A reader YTHDF2 supresses pro-inflammatory pathways and sustains hematopoietic stem cell function ', Journal of Experimental Medicine, vol. 218, no. 3, e20200829 . https://doi.org/10.1084/jem.20200829, https://doi.org/10.1084/jem.20200829
The Journal of Experimental Medicine
Mapperley, C, Lagemaat, L N V D, Lawson, H, Tavosanis, A, Paris, J, Campos, J, Wotherspoon, D, Durko, J, Sarapuu, A, Choe, J, Ivanova, I, Krause, D S, Kriegsheim, A V, Much, C, Morgan, M, Gregory, R I, Mead, A J, O’Carroll, D & Kranc, K R 2021, ' The mRNA m6A reader YTHDF2 suppresses proinflammatory pathways and sustains hematopoietic stem cell function ', Journal of Experimental Medicine . https://doi.org/10.1084/jem.20200829

The m6A reader YTHDF2 is a novel regulator of inflammatory pathways in HSCs. YTHDF2 loss upregulates m6A-modified proinflammatory transcripts, resulting in chronic HSC inflammatory activation, myeloid bias, and functional exhaustion.
The mRNA N6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7541c039acd58023bdb87812d6d74d92
https://doi.org/10.1084/jem.20200829

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Monitoring Protein-RNA Interaction Dynamics in vivo at High Temporal Resolution using χCRAC

Autor: Stuart W, McKellar, Ivayla, Ivanova, Robert W, van Nues, Ross A, Cordiner, Will, Worboys, Andrew, Langford, Torben Heick, Jensen, Sander, Granneman

Publikováno v: Journal of visualized experiments : JoVE. (159)

The interaction between RNA-binding proteins (RBPs) and their RNA substrates exhibits fluidity and complexity. Within its lifespan, a single RNA can be bound by many different RBPs that will regulate its production, stability, activity, and degradati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0337f3a228852d48573dcfb463434bf4
https://pubmed.ncbi.nlm.nih.gov/32449723

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Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia

Publikováno v: Cell Stem Cell
Cell Stem Cell, Cambridge, MA : Cell Press, 2019, 25 (1), pp.137-148.e6. ⟨10.1016/j.stem.2019.03.021⟩
Paris, J, Morgan, M, Monteiro De Campos, J, Spencer, G J, Shmakova, A, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Pires Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Guitart, A, Villacreces, A, Much, C, Choe, J, Anvari Azar, A, Van De Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T C P, Gregory, R I, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m 6 A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia ', Cell Stem Cell, vol. 25, no. 1, pp. 137-148.E6 . https://doi.org/10.1016/j.stem.2019.03.021
Paris, J, Morgan, M, Campos, J, Spencer, G, Shmakova, E, Ivanova, I, Mapperley, C, Lawson, H, Wotherspoon, D, Sepulveda, C, Vukovic, M, Allen, L, Sarapuu, A, Tavosanis, A, Villacreces, A, Much, C, Choe, J, Azar, A, van de Lagemaat, L, Vernimmen, D, Nehme, A, Mazurier, F, Somervaille, T, Gregory, R, O'Carroll, D & Kranc, K 2019, ' Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia ', Cell Stem Cell, vol. 25, no. 1, e6, pp. 137-148 . https://doi.org/10.1016/j.stem.2019.03.021

Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation generating self-renewing leukemic stem cells (LSCs). Here we show that the mRNA m6A r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73b00b59dad83bf24ff9587c68e68d11
https://hal-univ-tours.archives-ouvertes.fr/hal-02389825

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mRNA 3' uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome

Autor: Dimitrios Vitsios, Jelena Pistolic, Pedro Ventura De Oliveira Moreira, Christian Much, Vladimir Benes, Marcos Morgan, Chiara Azzi, Paul Collier, Dónal O'Carroll, Anton J. Enright, Monica DiGiacomo, Ivayla Ivanova

Publikováno v: Nature
Morgan, M, Much, C, DiGiacomo, M, Azzi, C, Ivanova, I, Vitsios, D M, Pistolic, J, Collier, P, Ventura De Oliveira Moreira, P, Benes, V, Enright, A J & O'Carroll, D 2017, ' mRNA 3ʹ uridylation and poly(A) tail length sculpt the mammalian maternal transcriptome ', Nature, vol. 548, pp. 347-351 . https://doi.org/10.1038/nature23318

TUT4 and TUT7 mediate 3′ uridylation of mRNA transcripts, preferentially those with short poly(A) tails; in the absence of TUT4 and TUT7, oocytes cannot mature and female mice are infertile. After fertilization, early embryonic events are dictated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::123eaf21906f059cb309c61a3835cfeb

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