Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ivars Silamiķelis"'
Autor:
Laura Ansone, Monta Briviba, Ivars Silamikelis, Anna Terentjeva, Ingus Perkons, Liga Birzniece, Vita Rovite, Baiba Rozentale, Ludmila Viksna, Oksana Kolesova, Kristaps Klavins, Janis Klovins
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 3 (2021)
ABSTRACT The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for early molecular characterization of patients followed by risk-stratified care. The main objective of this study was to evaluate the fluctuations of se
Externí odkaz:
https://doaj.org/article/a8441b1ccb9c4a108bdcfc6a79d47d13
Autor:
Ilze Elbere, Ivars Silamikelis, Monta Ustinova, Ineta Kalnina, Linda Zaharenko, Raitis Peculis, Ilze Konrade, Diana Maria Ciuculete, Christina Zhukovsky, Dita Gudra, Ilze Radovica-Spalvina, Davids Fridmanis, Valdis Pirags, Helgi B. Schiöth, Janis Klovins
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background Metformin is a widely prescribed antihyperglycemic agent that has been also associated with multiple therapeutic effects in various diseases, including several types of malignancies. There is growing evidence regarding the contrib
Externí odkaz:
https://doaj.org/article/1dae33c968ed4993b33f70dbe50c084b
Autor:
Ilze Elbere, Ineta Kalnina, Ivars Silamikelis, Ilze Konrade, Linda Zaharenko, Kristine Sekace, Ilze Radovica-Spalvina, Davids Fridmanis, Dita Gudra, Valdis Pirags, Janis Klovins
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204317 (2018)
BACKGROUND:Metformin is a widely used first-line drug for treatment of type 2 diabetes. Despite its advantages, metformin has variable therapeutic effects, contraindications, and side effects. Here, for the very first time, we investigate the short-t
Externí odkaz:
https://doaj.org/article/d75c41f66a154872b1b1fc0f2fa82b14
Autor:
Laila Silamiķele, Rihards Saksis, Ivars Silamiķelis, Patrīcija Paulīne Kotoviča, Monta Brīvība, Ineta Kalniņa, Zane Kalniņa, Dāvids Fridmanis, Jānis Kloviņš
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTAntidiabetic drug metformin alters the gut microbiome composition in the context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about the intestinal si
Externí odkaz:
https://doaj.org/article/4a64372d4ca04d9dbf5867275cf17140
Autor:
Monta Brīvība, Laila Silamiķele, Ineta Kalniņa, Ivars Silamiķelis, Līga Birzniece, Laura Ansone, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionResearch findings of the past decade have highlighted the gut as the main site of action of the oral antihyperglycemic agent metformin despite its pharmacological role in the liver. Extensive evidence supports metformin’s modulatory eff
Externí odkaz:
https://doaj.org/article/6beaf56def1b40759d3844d059c0a2ee
Autor:
Monta Brīvība, Laila Silamiķele, Līga Birzniece, Laura Ansone, Kaspars Megnis, Ivars Silamiķelis, Līva Pelcmane, Daniella Borisova, Maija Rozenberga, Lauma Jagare, Ilze Elbere, Jānis Kloviņš
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 567 (2024)
The gut microbiome plays a pivotal role in the modulation of host responses during viral infections, and recent studies have underscored its significance in the context of coronavirus disease 2019 (COVID-19). We aimed to investigate the dynamics and
Externí odkaz:
https://doaj.org/article/d4ba938c0bea4b7aa13950221fb8dd53
Autor:
Monta Brīvība, Ivanna Atava, Raitis Pečulis, Ilze Elbere, Laura Ansone, Maija Rozenberga, Ivars Silamiķelis, Jānis Kloviņš
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 1151 (2024)
Numerous type 2 diabetes (T2D) polygenic risk scores (PGSs) have been developed to predict individuals’ predisposition to the disease. An independent assessment and verification of the best-performing PGS are warranted to allow for a rapid applicat
Externí odkaz:
https://doaj.org/article/be1bf08149234e0bb2b6a51c4331d1fb
Autor:
Raimonds Reščenko, Monta Brīvība, Ivanna Atava, Vita Rovīte, Raitis Pečulis, Ivars Silamiķelis, Laura Ansone, Kaspars Megnis, Līga Birzniece, Mārcis Leja, Liqin Xu, Xulian Shi, Yan Zhou, Andis Slaitas, Yong Hou, Jānis Kloviņš
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 20, p 15345 (2023)
Despite rapid improvements in the accessibility of whole-genome sequencing (WGS), understanding the extent of human genetic variation is limited by the scarce availability of genome sequences from underrepresented populations. Developing the populati
Externí odkaz:
https://doaj.org/article/8727ea7186bc4196a580b9f948361cbe
Autor:
Laila Silamiķele, Ivars Silamiķelis, Monta Ustinova, Zane Kalniņa, Ilze Elbere, Ramona Petrovska, Ineta Kalniņa, Jānis Kloviņš
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Effects of metformin, the first-line drug for type 2 diabetes therapy, on gut microbiome composition in type 2 diabetes have been described in various studies both in human subjects and animals. However, the details of the molecular mechanisms of met
Externí odkaz:
https://doaj.org/article/fa70e258c0524c028c9f7a617c75e902
Autor:
Raimonds Kasparinskis, Māris Krievāns, Julia Gaidelene, Monta Ustinova, Līga Birzniece, Dāvids Fridmanis, Jānis Karušs, Ivars Silamiķelis, Kristaps Lamsters, Olga Muter
Publikováno v:
Polar Biology. 43:2085-2099
Glacial lakes and their sediments are highly sensitive temporal markers of environmental variability. The combination of particular geographical conditions with climate changes makes the Mulajokull lakes an appropriate model for revealing some site-s