Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Ivars Kalvinsh"'
Autor:
Baiba Svalbe, Edgars Liepinsh, Ivars Kalvinsh, Maija Dambrova, Liga Zvejniece, Edijs Vavers, Marina Makrecka-Kuka, Elina Makarova, Vilnis Liepins
Publikováno v:
Pharmacology Biochemistry and Behavior. 160:21-29
S-phenylpiracetam is an optical isomer of phenotropil, which is a clinically used nootropic drug that improves physical condition and cognition. Recently, it was shown that S-phenylpiracetam is a selective dopamine transporter (DAT) inhibitor that do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6f5b4d80934fc23157fa7bf9dc9648
https://doi.org/10.1016/j.pbb.2017.07.009
https://doi.org/10.1016/j.pbb.2017.07.009
Autor:
Ivars Kalvinsh, Edvards Liepinsh, Viktors Andrianovs, Edgars Liepinsh, Andris Kazaks, Maija Dambrova, Diana Zelencova, Solveiga Grinberga, Marina Makrecka, Osvalds Pugovics, Einars Loza, Daina Lola, Janis Leitans, Daina Gustina, Kaspars Tars, Janis Kuka
Publikováno v:
Journal of Medicinal Chemistry. 57:2213-2236
γ-Butyrobetaine hydroxylase (BBOX) catalyzes the conversion of gamma butyrobetaine (GBB) to l-carnitine, which is involved in the generation of metabolic energy from long-chain fatty acids. BBOX inhibitor 3-(1,1,1-trimethylhydrazin-1-ium-2-yl)propan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67f8a5b44882fb411da6dd5cf248b569
https://doi.org/10.1021/jm401603e
https://doi.org/10.1021/jm401603e
Autor:
Ivars Kalvinsh, Edvards Liepinsh, Jekaterīna Ivanova, Raivis Žalubovskis, Rihards Aleksis, Kristaps Jaudzems
Publikováno v:
Chemistry of Heterocyclic Compounds. 49:1589-1598
We describe studies of aziridine-2-carboxamide (Leakadine) reactivity with N-, O-, and S-nucleophiles in aqueous solutions using NMR spectroscopy and chemical synthesis. The results show that nucleophilic ring opening reactions of Leakadine with N- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c468e505f6ceec5c10c178243b783b42
https://doi.org/10.1007/s10593-014-1410-x
https://doi.org/10.1007/s10593-014-1410-x
The cognition‐enhancing activity of E1R , a novel positive allosteric modulator of sigma‐1 receptors
Autor:
Ivars Kalvinsh, Ilona Domracheva, Grigory Veinberg, Ilmars Stonans, Liga Zvejniece, Edijs Vavers, Reinis Vilskersts, Maxim Vorona, Ilga Misane, Maija Dambrova, Baiba Svalbe
Publikováno v:
British Journal of Pharmacology. 171:761-771
Background and Purpose Here, we describe the in vitro and in vivo effects of (4R,5S)-2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide (E1R), a novel positive allosteric modulator of sigma-1 receptors. Experimental Approach E1R was tested for sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47a3043a702c0a52d6f6da22532918b
https://doi.org/10.1111/bph.12506
https://doi.org/10.1111/bph.12506
Autor:
Janis Kuka, Edgars Liepinsh, Ivars Kalvinsh, Helena Cirule, Reinis Vilskersts, Anita Gulbe, Maija Dambrova
Publikováno v:
Magnesium Research. 27:16-24
The administration of magnesium supplements and nitrates/nitrites decreases arterial blood pressure and attenuates the development of hypertension-induced complications. This study was performed to examine the effects of treatment with magnesium nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d736a43619c5db4cf073be2bf75c40
https://doi.org/10.1684/mrh.2014.0358
https://doi.org/10.1684/mrh.2014.0358
Autor:
Annemette Thougaard, Søren Jensby Nielsen, Peter Buhl Jensen, Antje Garten, Kamille Dumong Erichsen, Mette Knak Christensen, Fredrik Björkling, Maxwell Sehested, Einars Loza, Uffe H. Olesen, Wieland Kiess, Peter Fristrup, Jette Tjørnelund, Ivars Kalvinsh
Publikováno v:
Journal of Medicinal Chemistry. 56:9071-9088
Existing pharmacological inhibitors for nicotinamide phosphoribosyltransferase (NAMPT) are promising therapeutics for treating cancer. By using medicinal and computational chemistry methods, the structure-activity relationship for novel classes of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081f0a0a1aec13bef735937cba0abf71
https://doi.org/10.1021/jm4009949
https://doi.org/10.1021/jm4009949
Autor:
Vija Klusa, Nikolajs Sjakste, Juris Rumaks, Jelena Sharipova, Ivars Kalvinsh, N. Karajeva, Jelizaveta Sokolovska, D. Grinvalde
Publikováno v:
Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry. 6:177-184
Rats with the streptozotocin (STZ) model of diabetes mellitus were treated with mildronate (100 mg/kg daily, per os or intraperitoneally) for 6 weeks. Body weight, blood glucose, triglycerides, ketone body concentrations, percent of glycated hemoglob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d57668cfc942d4b2873c8be281c65a1
https://doi.org/10.1134/s1990750812020114
https://doi.org/10.1134/s1990750812020114
Autor:
Grigory Veinberg, Ivars Kalvinsh, Liga Zvejniece, Solveiga Grinberga, Maija Dambrova, Maksims Vorona, Baiba Svalbe
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 109:407-412
Phenotropil (N-carbamoylmethyl-4-aryl-2-pyrrolidone (2-(2-oxo-4-phenyl-pyrrolidin-1-yl) acetamide; carphedon)) is clinically used in its racemic form as a nootropic drug that improves physical condition and cognition. The aim of this study was to com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95fc070d699b31bae2e2efd1cdc33441
https://doi.org/10.1111/j.1742-7843.2011.00742.x
https://doi.org/10.1111/j.1742-7843.2011.00742.x
Autor:
Ivars Kalvinsh, N. Karajeva, Kluša, Grīnvalde D, Juris Rumaks, Shapirova J, Jelizaveta Sokolovska, Nikolajs Sjakste
Publikováno v:
Biomeditsinskaya Khimiya. 57:490-500
Streptozotocin (STZ) was used to induce the diabetic rat model. STZ rats were treated with mildronate (100 mg/kg daily, per os or intraperitoneally for 6 weeks). Body weight, blood glucose, triglyceride, ketone body concentrations, glycated hemoglobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56348b081d2c4eece5f87b6cdea78579
https://doi.org/10.18097/pbmc20115705490
https://doi.org/10.18097/pbmc20115705490
Autor:
Tatjana Sjakste, Ivars Kalvinsh, Lasma Lauberte, Jelena Sharipova, Darja Svirina, Sergejs Isajevs, Evita Rostoka, Olga Sugoka, Jelizaveta Sokolovska, Nikolajs Sjakste
Publikováno v:
Cell Biochemistry and Function. 29:55-63
Anti-ischaemic drug mildronate suppresses fatty acid metabolism and increases glucose utilization in myocardium. It was proposed that it could produce a favourable effect on metabolic parameters and glucose transport in diabetic animals. Rats with st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a0ac314f8b51618611ff294bd139ad
https://doi.org/10.1002/cbf.1719
https://doi.org/10.1002/cbf.1719