Xrn1-resistant RNA motifs are disseminated throughout the RNA virome and are able to block scanning ribosomes

Autor: Ivar W. Dilweg, Jasper Peer, René C. L. Olsthoorn

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Abstract RNAs that are able to prevent degradation by the 5’–3’ exoribonuclease Xrn1 have emerged as crucial structures during infection by an increasing number of RNA viruses. Several plant viruses employ the so-called coremin motif, an Xrn1-r

Externí odkaz: https://doaj.org/article/e09aa285a3124f63aa9a04cfbeaa257b

All genera of Flaviviridae host a conserved Xrn1-resistant RNA motif

Autor: Anya Savina, René C. L. Olsthoorn, Peter J. Bredenbeek, Ivar W. Dilweg, Susanne Köthe, Alexander P. Gultyaev

Publikováno v: RNA Biology, 18(12), 2321-2329. Informa UK Limited
RNA Biology, 18(12), 2321-2329. Landes Bioscience
RNA Biology, 18(12), 2321-2329. TAYLOR & FRANCIS INC
RNA Biology
article-version (VoR) Version of Record

After infection by flaviviruses like Zika and West Nile virus, eukaryotic hosts employ the well-conserved endoribonuclease Xrn1 to degrade the viral genomic RNA. Within the 3MODIFIER LETTER PRIME untranslated regions, this enzyme encounters intricate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5b7e3f6f4f59c588b3b450b31e225f
https://hdl.handle.net/1887/3249081

A widespread Xrn1-resistant RNA motif composed of two short hairpins

Autor: René C. L. Olsthoorn, Ivar W. Dilweg, Alexander P. Gultyaev

Xrn1 is a major 5′-3′ exoribonuclease involved in the RNA metabolism of many eukaryotic species. RNA viruses have evolved ways to thwart Xrn1 in order to produce subgenomic non-coding RNA that affects the hosts RNA metabolism. The 3’ untranslat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fdf5f20a8c8dcffe2a522f20506d6d0
https://doi.org/10.1101/522318