Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Ivar Roots"'
Publikováno v:
Was ist Gesundheit? ISBN: 9783110713336
Was ist Gesundheit?
Was ist Gesundheit?
The Emergence of Modern Medicine and a New Understanding of Health and Disease: Rudolf Virchow and the Berlin Medical Society. At the beginning of the 19th century, the most important cities for medicine were Paris and Vienna. Berlin had less than 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50557d4bc832491490ccabd6db7f8ca
https://edoc.bbaw.de/frontdoor/index/index/docId/3670
https://edoc.bbaw.de/frontdoor/index/index/docId/3670
Publikováno v:
International Journal of Colorectal Disease. 24:171-175
Colorectal cancer incidence and prognosis are influenced by vitamin D intake and expression of the vitamin D receptor (VDR). Polymorphisms of the VDR are linked to several diseases. This study was aimed to investigate whether variants of the VDR poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee826904b0b08c01e0b0b23b965b1a0
https://doi.org/10.1007/s00384-008-0617-7
https://doi.org/10.1007/s00384-008-0617-7
Publikováno v:
Sleep Medicine. 9:579-582
Objective Tolterodine, a drug for the treatment of overactive bladder symptoms, has a limited entry into the brain, which makes cognitive side effects seldom. However, some case reports have described central-nervous side effects such as sleepiness.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bffaba1176caeb7e8abc62ee5e8ef45
https://doi.org/10.1016/j.sleep.2007.07.019
https://doi.org/10.1016/j.sleep.2007.07.019
Autor:
Elena R. Lebedeva, Jürgen Brockmöller, Rainer Lorch, Julia Kirchheiner, Angela Seeringer, Ivar Roots, Johanna Sasse
Publikováno v:
Pharmacogenomics. 9:841-846
Introduction: Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis is a pathogenic mechanism of depression, and genetic polymorphisms in HPA axis genes have been described to influence response to antidepressant drugs. In particular, tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b1e34520f1f4b06ae178eecea52455
https://doi.org/10.2217/14622416.9.7.841
https://doi.org/10.2217/14622416.9.7.841
Publikováno v:
ResearcherID
The concentration ratio of morphine (Mor) over codeine (Cod) in opiate positive blood samples is used to discriminate between the use of illegal heroin (high ratios) and therapeutic codeine (low ratios). However, genetically caused CYP2D6 ultra-rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17221b362dc12b66d7933ba95ef792af
https://doi.org/10.1093/jat/32.2.178
https://doi.org/10.1093/jat/32.2.178
Publikováno v:
European Journal of Clinical Pharmacology. 64:257-266
OATP1B1 is one of the key hepatocellular uptake transporters providing extraction of diverse compounds, including bile acids, xenobiotics, and a variety of drugs, from portal venous blood into the liver. Polymorphisms of the SLCO1B1 gene have been de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4975a629b533aae33a144b8e255acc6a
https://doi.org/10.1007/s00228-007-0409-y
https://doi.org/10.1007/s00228-007-0409-y
Autor:
Thomas Gerloff, Karla Köpke, Jury N. Chernov, Ivar Roots, Uwe Malzahn, Farhad Arjomand-Nahad, Andreas Johne, Elena Osswald, Julia Kirchheiner, Gabriele Laschinski, Przemyslaw M. Mrozikiewicz, Christian Meisel
Publikováno v:
European Journal of Clinical Pharmacology. 63:9-16
The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. The importance of MDR1 SNPs 2677GT/A in exon 21 and 3435CT in exon 26 for cancer susceptibility, however, has not yet been clearly defined.Two hun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fbbae4dc0119d84755e991bc350017
https://doi.org/10.1007/s00228-006-0225-9
https://doi.org/10.1007/s00228-006-0225-9
Autor:
Karla Köpke, Konstanze Diefenbach, Karl Stangl, Christian Meisel, Ivar Roots, Ingo Fietze, Farhad Arjomand-Nahad
Publikováno v:
Genetic Testing. 10:163-168
We analyzed allele frequencies and pairwise linkage disequilibria of 13 variants in the EDN1 gene of 298 young males, the majority of German ancestry. Our analysis comprises all common variants in the five exons and flanking intronic regions, as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ac6deb7b1c6cd4c10ada021387be76
https://doi.org/10.1089/gte.2006.10.163
https://doi.org/10.1089/gte.2006.10.163
Autor:
Thomas Gerloff, Ivar Roots, Klaus von Bergmann, Melanie Schaefer, Thomas Sudhop, Andreas Johne, Dieter Lütjohann, Jessica Mwinyi
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 373:45-50
We previously showed that variant SLCO1B1 haplotype *1b (A388G) accelerates and that *5 (T521C) delays hepatocellular uptake of the HMG-CoA reductase inhibitor pravastatin [Mwinyi et al. (2004): Clin Pharmacol Ther 75:415-421]. In the present study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc7814239391e528acc7d9fb40e582b
https://doi.org/10.1007/s00210-006-0053-6
https://doi.org/10.1007/s00210-006-0053-6