Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Ivar McDonald"'
1
Akademický článek
Evaluation of antisense oligonucleotide therapy targeting Hsd17b13 in a fibrosis mice model
Autor: Yanling Ma, Hong Cai, Julia Smith, Ching-Hsuen Chu, Stephen E. Mercer, Stephanie Boehm, Ivar Mcdonald, Bradley Zinker, Dong Cheng
Publikováno v: Journal of Lipid Research, Vol 65, Iss 3, Pp 100514- (2024)
Human genetic evidence suggests a protective role of loss-of-function variants in 17-beta hydroxysteroid dehydrogenase 13 (HSD17B13) for liver fibrotic diseases. Although there is limited preclinical experimental data on Hsd17b13 antisense oligonucle
Externí odkaz: https://doaj.org/article/961d2ae3e8bd48ffa4f295bbb6a4f902
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2
Akademický článek
Allele-Selective Knockdown of MYH7 Using Antisense Oligonucleotides
Autor: Brian R. Anderson, Marianne L. Jensen, Peter H. Hagedorn, Sean C. Little, Richard E. Olson, Ron Ammar, Bernadette Kienzle, John Thompson, Ivar McDonald, Stephen Mercer, Jonas Vikesaa, Bettina Nordbo, Larry Iben, Yang Cao, Joanne Natale, Greg Dalton-Kay, Angela Cacace, Bo R. Hansen, Maj Hedtjärn, Troels Koch, Linda J. Bristow
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 19, Iss , Pp 1290-1298 (2020)
Hundreds of dominant-negative myosin mutations have been identified that lead to hypertrophic cardiomyopathy, and the biomechanical link between mutation and disease is heterogeneous across this patient population. To increase the therapeutic feasibi
Externí odkaz: https://doaj.org/article/ebaf673f331045b1903490834433fa8c
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3
A P(V)-Platform for Oligonucleotide Synthesis
Autor: Ivar Mcdonald, Mike Schmidt, Martin Eastgate, Donna Blackmond, Richard Olson, Rohan Narayan, Javier Lopez, Stephen Mercer, Bin Zheng, Julien Vantourout, Natalia Padial, wei hao, Shenjie Qiu, Yazhong Huang, Kyle W. Knouse, Phil Baran
The early promise of gene-based therapies is currently being realized at an accelerated pace with over 155 active clinical trials for antisense compounds and multiple FDA-approved oligonucleotide therapeutics. Fundamental advances in this area are vi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53cb0675618b0aa8bfe08af9461aff4f
https://doi.org/10.26434/chemrxiv.14403488
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