Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease

Autor: Kerr, F, Sofola-Adesakin, O, Ivanov, DK, Gatliff, J, Perez-Nievas, BG, Bertrand, HC, Martinez, P, Callard, R, Snoeren, I, Cocheme, HM, Adcott, J, Khericha, M, Castillo-Quan, JI, Wells, G, Noble, W, Thornton, J, Partridge, L

Publikováno v: PLoS Genet
PLoS Genetics, Vol 13, Iss 3, p e1006593 (2017)

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway ove

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0c754041ac487a896d47d0842e2d4784
https://hdl.handle.net/21.11116/0000-000B-4F6A-7

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Golgi apparatus, endoplasmic reticulum and mitochondrial function implicated in Alzheimer's disease through polygenic risk and RNA sequencing.

Autor: Crawford K; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, School of Medicine, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Leonenko G; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Baker E; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Grozeva D; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK.; Centre for Trials Research, Cardiff University, Cardiff, CF24 4HQ, UK., Lan-Leung B; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Holmans P; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, School of Medicine, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Williams J; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., O'Donovan MC; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, School of Medicine, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Escott-Price V; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, School of Medicine, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK., Ivanov DK; UK Dementia Research Institute (UKDRI) at Cardiff University, College of Biomedical and Life Sciences, Hadyn Ellis Building, Cardiff, CF24 4HQ, UK. IvanovD1@cardiff.ac.uk.

Publikováno v: Molecular psychiatry [Mol Psychiatry] 2023 Mar; Vol. 28 (3), pp. 1327-1336. Date of Electronic Publication: 2022 Dec 28.

Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system.

Autor: Bolukbasi E; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Woodling NS; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Ivanov DK; European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, United Kingdom.; UK Dementia Research Institute, Cardiff University, Cardiff CF24 4HQ, United Kingdom., Adcott J; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Foley A; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Rajasingam A; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Gittings LM; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Aleyakpo B; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Niccoli T; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom., Thornton JM; European Bioinformatics Institute, European Molecular Biology Laboratory, Cambridge CB10 1SD, United Kingdom., Partridge L; Institute of Healthy Ageing, University College London, London WC1E 6BT, United Kingdom; l.partridge@ucl.ac.uk.; Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United Kingdom.; Department of Biological Mechanisms of Ageing, Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Feb 23; Vol. 118 (8).

Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity.

Autor: Bolukbasi E; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany., Khericha M; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany., Regan JC; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany., Ivanov DK; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Adcott J; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK., Dyson MC; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK., Nespital T; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany., Thornton JM; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Alic N; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK., Partridge L; Institute of Healthy Ageing, Department of Genetics, Evolution and Environment, University College London, Gower St, London WC1E 6BT, UK; Max Planck Institute for Biology of Ageing, Joseph-Stelzmann-Strasse 9b, 50931 Cologne, Germany. Electronic address: l.partridge@ucl.ac.uk.

Publikováno v: Cell reports [Cell Rep] 2017 Oct 17; Vol. 21 (3), pp. 641-653.