Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ivano Legnini"'
Autor:
Pawel Lisowski, Selene Lickfett, Agnieszka Rybak-Wolf, Carmen Menacho, Stephanie Le, Tancredi Massimo Pentimalli, Sofia Notopoulou, Werner Dykstra, Daniel Oehler, Sandra López-Calcerrada, Barbara Mlody, Maximilian Otto, Haijia Wu, Yasmin Richter, Philipp Roth, Ruchika Anand, Linda A. M. Kulka, David Meierhofer, Petar Glazar, Ivano Legnini, Narasimha Swamy Telugu, Tobias Hahn, Nancy Neuendorf, Duncan C. Miller, Annett Böddrich, Amin Polzin, Ertan Mayatepek, Sebastian Diecke, Heidi Olzscha, Janine Kirstein, Cristina Ugalde, Spyros Petrakis, Sidney Cambridge, Nikolaus Rajewsky, Ralf Kühn, Erich E. Wanker, Josef Priller, Jakob J. Metzger, Alessandro Prigione
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-27 (2024)
Abstract Expansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic in
Externí odkaz:
https://doaj.org/article/340c015abcae4c679391b04ea77b6a41
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105878- (2023)
Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm. Here, we combin
Externí odkaz:
https://doaj.org/article/c7bb01dd2b394ec3af9326155ab43862
Autor:
Andreia Gomes-Duarte, Morten T. Venø, Marina de Wit, Ketharini Senthilkumar, Mark H. Broekhoven, Joëlle van den Herik, Fleur R. Heeres, Daniëlle van Rossum, Mateja Rybiczka-Tesulov, Ivano Legnini, Peter C. van Rijen, Pieter van Eijsden, Peter H. Gosselaar, Nikolaus Rajewsky, Jørgen Kjems, Vamshidhar R. Vangoor, R. Jeroen Pasterkamp
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Mesial temporal lobe epilepsy (mTLE) is a chronic disease characterized by recurrent seizures that originate in the temporal lobes of the brain. Anti-epileptic drugs (AEDs) are the standard treatment for managing seizures in mTLE patients, but are fr
Externí odkaz:
https://doaj.org/article/410e483a1b334ae3bc86f6ea487598f0
Autor:
Emanuel Wyler, Kirstin Mösbauer, Vedran Franke, Asija Diag, Lina Theresa Gottula, Roberto Arsiè, Filippos Klironomos, David Koppstein, Katja Hönzke, Salah Ayoub, Christopher Buccitelli, Karen Hoffmann, Anja Richter, Ivano Legnini, Andranik Ivanov, Tommaso Mari, Simone Del Giudice, Jan Papies, Samantha Praktiknjo, Thomas F. Meyer, Marcel Alexander Müller, Daniela Niemeyer, Andreas Hocke, Matthias Selbach, Altuna Akalin, Nikolaus Rajewsky, Christian Drosten, Markus Landthaler
Publikováno v:
iScience, Vol 24, Iss 3, Pp 102151- (2021)
Summary: Detailed knowledge of the molecular biology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is crucial for understanding of viral replication, host responses, and disease progression. Here, we report gene expression
Externí odkaz:
https://doaj.org/article/aa494f159d1e4728b02c9632c197db4f
Autor:
Lorenzo Errichelli, Stefano Dini Modigliani, Pietro Laneve, Alessio Colantoni, Ivano Legnini, Davide Capauto, Alessandro Rosa, Riccardo De Santis, Rebecca Scarfò, Giovanna Peruzzi, Lei Lu, Elisa Caffarelli, Neil A. Shneider, Mariangela Morlando, Irene Bozzoni
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The RNA binding protein FUS functions in several RNA biosynthetic processes and has been linked to the pathogenesis of amyotrophic lateral sclerosis (ALS). Here the authors show that FUS controls back-splicing reactions leading to circular RNA (circR
Externí odkaz:
https://doaj.org/article/1e9c2716f18a4d80882bcb92f54bc792
Autor:
Carlos Alfonso-Gonzalez, Ivano Legnini, Sarah Holec, Laura Arrigoni, Hasan Can Ozbulut, Fernando Mateos, David Koppstein, Agnieszka Rybak-Wolf, Ulrike Bönisch, Nikolaus Rajewsky, Valérie Hilgers
Publikováno v:
Cell
The generation of distinct messenger RNA isoforms through alternative RNA processing modulates the expression and function of genes, often in a cell-type-specific manner. Here, we assess the regulatory relationships between transcription initiation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be45e3b1161b4456ad8bcfed4150a2f0
http://edoc.mdc-berlin.de/23360/1/23360oa.pdf
http://edoc.mdc-berlin.de/23360/1/23360oa.pdf
Autor:
Tancredi Massimo Pentimalli, Simon Schallenberg, Daniel León-Periñán, Ivano Legnini, Ilan Theurillat, Gwendolin Thomas, Anastasiya Boltengagen, Sonja Fritzsche, Jose Nimo, Lukas Ruff, Gabriel Dernbach, Philipp Jurmeister, Sarah Murphy, Mark T. Gregory, Yan Liang, Michelangelo Cordenonsi, Stefano Piccolo, Fabian Coscia, Andrew Woehler, Nikos Karaiskos, Frederick Klauschen, Nikolaus Rajewsky
Cells live and interact in three-dimensional (3D) cellular neighborhoods. However, histology and spatial omics methods mostly focus on 2D tissue sections. Here we present a 3D spatial atlas of a routine clinical sample, an aggressive human lung carci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2dece52ca4a6ff05fd9d0d0c8bbbcdc
https://doi.org/10.1101/2023.05.10.539644
https://doi.org/10.1101/2023.05.10.539644
Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm. Here, we combined long-r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70417d74c6daf17e0dc52c1040f33aab
http://edoc.mdc-berlin.de/23011/1/23011oa.pdf
http://edoc.mdc-berlin.de/23011/1/23011oa.pdf
Autor:
Grygoriy Zolotarov, Bastian Fromm, Ivano Legnini, Salah Ayoub, Gianluca Polese, Valeria Maselli, Peter J. Chabot, Jakob Vinther, Ruth Styfhals, Eve Seuntjens, Anna Di Cosmo, Kevin J. Peterson, Nikolaus Rajewsky
Soft-bodied cephalopods such as the octopus are exceptionally intelligent invertebrates with a highly complex nervous system that evolved independently from vertebrates. Because of elevated RNA editing in their nervous tissues, we hypothesized that R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b52e08d68126c2b68ee1665bc166266
http://edoc.mdc-berlin.de/22911/1/22911oa.pdf
http://edoc.mdc-berlin.de/22911/1/22911oa.pdf
Autor:
Anna Oliveras Martinez, Cledi Alicia Cerda Jara, Guido Mastrobuoni, Andrew Woehler, Stefan Kempa, Anastasiya Boltengagen, Tale Hessler, Ricardo Wurmus, Alessandra Zappulo, Agnieszka Rybak-Wolf, Lisa Emmenegger, Nikolaus Rajewsky, Ivano Legnini, Robert P. Zinzen
Organoids derived from stem cells become increasingly important to study human development and to model disease. However, methods are needed to control and study spatio-temporal patterns of gene expression in organoids. To this aim, we combined optog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d7ae1b7891b128f8e583e80ea3118c
http://edoc.mdc-berlin.de/21329/1/21329oa.pdf
http://edoc.mdc-berlin.de/21329/1/21329oa.pdf