Ankstyvos skrandžio vėžio bei ikivėžinių būklių diagnostikos galimybių įvertinimas

Autor: Ivanauskas, Audrius

Visame pasaulyje skrandžio vėžys yra didelė problema, kasmet diagnozuojama apie 875000 naujų atvejų ir 645000 miršta nuo šios ligos. Lietuvos vėžio registro duomenimis, 2005 m. Lietuvoje sergamumas skrandžio vėžiu buvo 35,0 vyrų ir 22,1

Externí odkaz: http://vddb.library.lt/fedora/get/LT-eLABa-0001:E.02~2008~D_20080319_133515-70953/DS.005.0.02.ETD

Phase 1/2a trial of nadunolimab, a first-in-class fully humanized monoclonal antibody against IL1RAP, in combination with gemcitabine and nab-paclitaxel (GN) in patients with pancreatic adenocarcinoma (PDAC)

Autor: Cutsem, Eric, Eefsen, Rikke Lovendahl, Sebastian Ochsenreither, Zvirbule, Zanete, Ivanauskas, Audrius, Arnold, Dirk, Baltruskeviciene, Edita, Pfeiffer, Per, Yachnin, Jeffrey, Garcia Carbonero, Rocio, Greil, Richard, Jungels, Christiane, Poulsen, Laurids, Awada, Ahmad, Garcia Ribas, Ignacio, Losic, Nedjad, Collignon, Joelle

Publikováno v: Van Cutsem, E, Eefsen, R L, Ochsenreither, S, Zvirbule, Z, Ivanauskas, A, Arnold, D, Baltruskeviciene, E, Pfeiffer, P, Yachnin, J, Garcia Carbonero, R, Greil, R, Jungels, C, Poulsen, L, Awada, A, Garcia Ribas, I, Losic, N & Collignon, J 2022, ' Phase 1/2a trial of nadunolimab, a first-in-class fully humanized monoclonal antibody against IL1RAP, in combination with gemcitabine and nab-paclitaxel (GN) in patients with pancreatic adenocarcinoma (PDAC). ', Journal of Clinical Oncology, vol. 40, no. Suppl. 16, pp. 4141 . < https://ascopubs.org/doi/abs/10.1200/JCO.2022.40.16_suppl.4141 >
Web of Science

4141 Background: Interleukin-1 Receptor Accessory Protein (IL1RAP) is expressed on cancer and stromal cells in PDAC. The IL-1 pathway is active in the pancreatic tumor microenvironment and upregulated in response to chemotherapy. IL1RAP interacts wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab54ad0b1145eb4e3bda2e7e8f52859
https://vbn.aau.dk/da/publications/41e10015-43bf-4647-9aaa-eb976c04bada

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Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction

Autor: Galeotti, Alice Alessandra Gentiluomo, Manuel Rizzato, Cosmeri and Obazee, Ofure Neoptolemos, John P. Pasquali, Claudio and Nentwich, Michael Cavestro, Giulia Martina Pezzilli, Raffaele and Greenhalf, William Holleczek, Bernd Schroeder, Cornelia and Schottker, Ben Ivanauskas, Audrius Ginocchi, Laura Key, Timothy J. Hegyi, Peter Archibugi, Livia Darvasi, Erika and Basso, Daniela Sperti, Cosimo Bijlsma, Maarten F. Palmieri, Orazio Hlavac, Viktor Talar-Wojnarowska, Renata and Mohelnikova-Duchonova, Beatrice Hackert, Thilo Vashist, Yogesh and Strouhal, Ondrej van Laarhoven, Hanneke Tavano, Francesca and Lovecek, Martin Dervenis, Christos Izbeki, Ferenc and Padoan, Andrea Malecka-Panas, Ewa Maiello, Evaristo Vanella, Giuseppe Capurso, Gabriele Izbicki, Jakob R. Theodoropoulos, George E. Jamroziak, Krzysztof Katzke, Verena Kaaks, Rudolf and Mambrini, Andrea Papanikolaou, Ioannis S. Szmola, Richard and Szentesi, Andrea Kupcinskas, Juozas Bursi, Simona and Costello, Eithne Boggi, Ugo Milanetto, Anna Caterina Landi, Stefano Gazouli, Maria Vodickova, Ludmila Soucek, Pavel and Gioffreda, Domenica Gemignani, Federica Brenner, Hermann and Strobel, Oliver Buechler, Markus Vodicka, Pavel Paiella, Salvatore Canzian, Federico Campa, Daniele

Background Most cases of pancreatic ductal adenocarcinoma (PDAC) are asymptomatic in early stages, and the disease is typically diagnosed in advanced phases, resulting in very high mortality. Tools to identify individuals at high risk of developing P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::94835b33f5e6235b486442bbdce754d2
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3029083

Association of Genetic Variants Affecting microRNAs and Pancreatic Cancer Risk

Autor: Lu, Ye Corradi, Chiara Gentiluomo, Manuel Lopez de Maturana, Evangelina Theodoropoulos, George E. Roth, Susanne Maiello, Evaristo Morelli, Luca Archibugi, Livia Izbicki, Jakob R. and Sarlos, Patricia Kiudelis, Vytautas Oliverius, Martin and Aoki, Mateus Nobrega Vashist, Yogesh van Eijck, Casper H. J. and Gazouli, Maria Talar-Wojnarowska, Renata Mambrini, Andrea and Pezzilli, Raffaele Bueno-de-Mesquita, Bas Hegyi, Peter and Soucek, Pavel Neoptolemos, John P. Di Franco, Gregorio and Sperti, Cosimo Kauffmann, Emanuele F. Hlavac, Viktor and Uzunoglu, Faik G. Ermini, Stefano Malecka-Panas, Ewa and Lucchesi, Maurizio Vanella, Giuseppe Dijk, Frederike and Mohelnikova-Duchonova, Beatrice Bambi, Franco Petrone, Maria Chiara Jamroziak, Krzysztof Guo, Feng Kolarova, Katerina and Capretti, Giovanni Milanetto, Anna Caterina Ginocchi, Laura and Lovecek, Martin Puzzono, Marta van Laarhoven, Hanneke W. M. and Carrara, Silvia Ivanauskas, Audrius Papiris, Konstantinos and Basso, Daniela Arcidiacono, Paolo G. Izbeki, Ferenc Chammas, Roger Vodicka, Pavel Hackert, Thilo Pasquali, Claudio and Piredda, Maria L. Costello-Goldring, Eithne Cavestro, Giulia Martina Szentesi, Andrea Tavano, Francesca Wlodarczyk, Barbara Brenner, Hermann Kreivenaite, Edita Gao, Xin and Bunduc, Stefania Vermeulen, Roel C. H. Schneider, Martin A. and Latiano, Anna Gioffreda, Domenica Testoni, Sabrina G. G. and Kupcinskas, Juozas Lawlor, Rita T. Capurso, Gabriele Malats, Nuria Campa, Daniele Canzian, Federico

Genetic factors play an important role in the susceptibility to pancreatic cancer (PC). However, established loci explain a small proportion of genetic heritability for PC; therefore, more progress is needed to find the missing ones. We aimed at iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::f4d0e7dc97cc2364711581e63a7f486f
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3030957