Cytotoxic CD8+ T cells promote granzyme B-dependent adverse post-ischemic cardiac remodeling

Autor: Icia Santos-Zas, Jeremie Lemarié, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Jin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, José Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, Patrick Bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-Sébastien Silvestre, Hafid Ait-Oufella

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Immune cells contribute to adverse remodeling following myocardial infarction. Here the authors show in mice and pigs that CD8+ lymphocytes release Granzyme B in the infarcted heart leading to cardiomyocyte death, enhanced inflammation and deteriorat

Externí odkaz: https://doaj.org/article/d22cf22ea4844f0bb37075c442f362fe

Single Cell Epigenetics Reveal Cell-Cell Communication Networks in Normal and Abnormal Cardiac Morphogenesis

Autor: Sanjeev S. Ranade, Sean Whalen, Ivana Zlatanova, Tomohiro Nishino, Benjamin van Soldt, Lin Ye, Angelo Pelonero, Langley Grace Wallace, Yu Huang, Michael Alexanian, Arun Padmanabhan, Barbara Gonzalez-Teran, Pawel Przytycki, Mauro W. Costa, Casey A. Gifford, Brian L. Black, Katherine S. Pollard, Deepak Srivastava

Communication between myriad cell types during organ formation underlies proper morphogenesis1. In cardiac development, reciprocal signaling between mesoderm progenitors and neural crest cells is essential, and its disruption leads to congenital hear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::643e949c5df7fd1acbf53c7827855649
https://doi.org/10.1101/2022.07.25.501458

N-Oleoyl dopamine induces IL-10 via central nervous system TRPV1 and improves endotoxemia and sepsis outcomes

Autor: Jérémie Joffre, Erika Wong, Samira Lawton, Elliot Lloyd, Nina Nguyen, Fengyun Xu, Cristina Sempio, Lester Kobzik, Ivana Zlatanova, Mark Schumacher, Jost Klawitter, Hua Su, Katalin Rabl, Kevin Wilhelmsen, Che-Chung Yeh, Judith Hellman

Publikováno v: Journal of neuroinflammation, vol 19, iss 1

BackgroundThe transient receptor potential vanilloid 1 (TRPV1) participates in thermosensation and inflammatory pain, but its immunomodulatory mechanisms remain enigmatic.N-Oleoyl dopamine (OLDA), an endovanilloid and endocannabinoid, is a TRPV1 agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0deba21895eee7429dafb75435c9e16
https://pubmed.ncbi.nlm.nih.gov/35610647

Cytotoxic CD8+ T Cells Promote Granzyme B-Dependent Adverse Post-Ischemic Cardiac Remodeling

Autor: Icia Santos Zas, Jeremie Lemarie, Ivana Zlatanova, Marine Cachanado, Jean-Christophe Seghezzi, Hakim Benamer, Pascal Goube, Marie Vandestienne, Raphael Cohen, Maya Ezzo, Vincent Duval, Yujiao Zhang, Gin-Bo Su, Alain Bizé, Lucien Sambin, Philippe Bonnin, Maxime Branchereau, Christophe Heymes, Corinne Tanchot, Jose Vilar, Clement Delacroix, Jean-Sebastien Hulot, Clement Cochain, patrick bruneval, Nicolas Danchin, Alain Tedgui, Ziad Mallat, Tabassome Simon, Bijan Ghaleh, Jean-sébastien Silvestre, Hafid Ait-Oufella

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-21737-9⟩
Nature Communications, 2021, 12 (1), ⟨10.1038/s41467-021-21737-9⟩

Acute myocardial infarction (MI) is a common condition responsible for heart failure and sudden death. Here, we show that following acute MI in mice, CD8+ T lymphocytes are recruited and activated in the ischemic heart tissue, and release Granzyme B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea3d8824a868ab9fb46b4deb13c26222
https://doi.org/10.21203/rs.3.rs-51324/v1

Activation of CB(1)R Promotes Lipopolysaccharide-Induced IL-10 Secretion by Monocytic Myeloid-Derived Suppressive Cells and Reduces Acute Inflammation and Organ Injury

Autor: Mayuri Vijay Thete, Elliot Lloyd, Judith Hellman, Jérémie Joffre, Che-Chung Yeh, Erika Wong, Fengyun Xu, Matthieu Legrand, Lester Kobzik, Ivana Zlatanova

Publikováno v: J Immunol

Cannabis sativa and its principal components, Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol, are increasingly being used to treat a variety of medical problems, including inflammatory conditions. Although studies suggest that the endocannabinoid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f152aa91461d29d01cf20a61b6cdeead
https://europepmc.org/articles/PMC7276941/