Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ivana R. Ferrer"'
Autor:
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v:
Cell Reports, Vol 39, Iss 7, Pp 110819- (2022)
Summary: T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute g
Externí odkaz:
https://doaj.org/article/960eba7bb8e8431f8c5a9ff4e7e81b08
Autor:
Pamela Evans, Simone Dertschnig, Ronjon Chakraverty, Hans J. Stauss, Pedro Santos e Sousa, Teresa Manzo, Clare L. Bennett, Ivana R. Ferrer
Publikováno v:
The Journal of Clinical Investigation
Acute graft-versus-host disease (GVHD) is initially triggered by alloreactive T cells, which damage peripheral tissues and lymphoid organs. Subsequent transition to chronic GVHD involves the emergence of autoimmunity, although the underlying mechanis
Autor:
Heather C. West, James Davies, Stephen Henderson, Oluyori K. Adegun, Sophie Ward, Ivana R. Ferrer, Chanidapa A. Tye, Andres F. Vallejo, Laura Jardine, Matthew Collin, Marta E. Polak, Clare L. Bennett
Publikováno v:
Cell reports. 39(7)
T cell pathology in the skin leads to monocyte influx, but we have little understanding of the fate of recruited cells within the diseased niche, or the long-term impact on cutaneous immune homeostasis. By combining a murine model of acute graft-vers
Autor:
Andrew J. Yates, Clare L. Bennett, Stephen Henderson, Pedro Santos e Sousa, Heather C. West, Ronjon Chakraverty, Dmitry S. Ushakov, Jessica Strid, Ivana R. Ferrer
Embryo-derived Langerhans cells (eLC) are maintained within the sealed epidermis without contribution from circulating cells. When the network is perturbed by transient exposure to ultra-violet light, short-term LC are temporarily reconstituted from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::805a570befa0839a19bb10d66c121b91
https://doi.org/10.1101/617514
https://doi.org/10.1101/617514
Autor:
Séverine Ciré, Terry K. Means, Matthew Collin, Stephen Henderson, Sophie Ward, Vincent Plagnol, Clare L. Bennett, Simone Dertschnig, Cara Lomas, Thomas Conlan, Sven Blobner, Ivana R. Ferrer, Ronjon Chakraverty, Daniel H. Kaplan, Claire Tkacz, Laura Jardine, Pedro Santos e Sousa, Heather C. West
Publikováno v:
JCI Insight
JCI Insight, Vol 3, Iss 5 (2018)
JCI Insight, Vol 3, Iss 5 (2018)
Graft-versus-host disease (GVHD) is a life-threatening complication of allogeneic stem cell transplantation induced by the influx of donor-derived effector T cells (TE) into peripheral tissues. Current treatment strategies rely on targeting systemic
Publikováno v:
Immunological Reviews
Organ transplantation results in the activation of both innate and adaptive immune responses to the foreign antigens. While these responses can be limited with the use of systemic immunosuppressants, the induction of regulatory cell populations may b
Current models of CD4+ T cell help suggest a major role for CD154 binding to CD40 expressed on dendritic cells, with a lesser role for direct T:T interactions via CD40 expressed on CD8+ T cells. However, the contribution of CD8+ T cell–derived CD40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d18359b74c6633a24ff7dbfea7071b
https://ora.ox.ac.uk/objects/uuid:a49d0ef6-b1b9-4b83-8b87-63d9b1a9b9c8
https://ora.ox.ac.uk/objects/uuid:a49d0ef6-b1b9-4b83-8b87-63d9b1a9b9c8
Blockade of the CD40/CD154 pathway remains one of the most effective means of promoting graft survival following transplantation. However, the effects of CD40/CD154 antagonism on dendritic cell (DC) phenotype and functionality following transplantati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971a8293f66faf093c6e3cfcdbdd966b
https://doi.org/10.4049/jimmunol.1201757
https://doi.org/10.4049/jimmunol.1201757
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 7, p e40559 (2012)
PLoS ONE, Vol 7, Iss 7, p e40559 (2012)
CD154/CD40 blockade combined with donor specific transfusion remains one of the most effective therapies in prolonging allograft survival. Despite this, the mechanisms by which these pathways synergize to prevent rejection are not completely understo
Autor:
Christian P. Larsen, Allan D. Kirk, Mandy L. Ford, Minqing Song, Maylene E. Wagener, Ivana R. Ferrer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(51)
Blockade of the CD40/CD154 pathway potently attenuates T-cell responses in models of autoimmunity, inflammation, and transplantation. Indeed, CD40 pathway blockade remains one of the most powerful methods of prolonging graft survival in models of tra