Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ivana Milackova"'
Autor:
Lenka Fáber, Ivan Kováč, Petra Mitrengová, Martin Novotný, Lenka Varinská, Tomáš Vasilenko, Martin Kello, Matúš Čoma, Tomáš Kuruc, Klaudia Petrová, Ivana Miláčková, Anika Kuczmannová, Vlasta Peržeľová, Štefánia Mižáková, Erik Dosedla, František Sabol, Ján Luczy, Milan Nagy, Jaroslav Majerník, Martin Koščo, Pavel Mučaji, Peter Gál
Publikováno v:
Molecules, Vol 23, Iss 7, p 1637 (2018)
Selective estrogen receptor modulators (SERMs) have been developed to achieve beneficial effects of estrogens while minimizing their side effects. In this context, we decided to evaluate the protective effect of genistein, a natural SERM, on skin fla
Externí odkaz:
https://doaj.org/article/491f2ac4c6f64d6a9807d5b0e142e40e
Publikováno v:
Chemical Papers. 71:2335-2341
The Cornaceae family is mainly known for the research connected with its fruits and flowers, but the biological activities of leaves of Cornus species are not very intensively studied. Present work is focused on inhibition of rat lens aldose reductas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1153b8815f533571a2ef2322826b0027
https://doi.org/10.1007/s11696-017-0227-3
https://doi.org/10.1007/s11696-017-0227-3
Publikováno v:
Phytotherapy Research. 31:488-496
The human intracellular enzyme AKR1B1 belongs to the aldo-keto reductase superfamily. The AKR1B1-catalyzed reduction of aldehydes is part of the intracellular inflammatory pathway leading to the activation of NF-κB and the expression of pro-inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f8f24c12f3e9a6368d27a8adb50dde2
https://doi.org/10.1002/ptr.5774
https://doi.org/10.1002/ptr.5774
Autor:
Jana Ballekova, Dolores Pérez-Sala, José A. G. Agúndez, Ivana Milackova, Beatriz Díez-Dacal, Tahl Zimmerman, Milan Stefek, Elena García-Martín, Severine Gharbi, Pedro A. Sánchez-Murcia, Francisco J. Sánchez-Gómez, Federico Gago
Publikováno v:
Molecular Pharmacology. 89:42-52
Aldose reductase (AKR1B1) is a critical drug target because of its involvement in diabetic complications, inflammation, and tumorigenesis. However, to date, development of clinically useful inhibitors has been largely unsuccessful. Cyclopentenone pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f41a57b6f16b3383f64b2a49367a464
https://doi.org/10.1124/mol.115.100693
https://doi.org/10.1124/mol.115.100693
Publikováno v:
Chemical Papers. 70
The novel derivative of quercetin 3′-O-(3-chloropivaloyl)quercetin (CPQ) inhibited a-glucosidase in a non-competitive manner with an efficacy exceeding that of the parent quercetin. In addition, it inhibited aldose reductase isolated from rat lense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13d2bd92811a29ab03be882ca6276d6d
https://doi.org/10.1515/chempap-2016-0078
https://doi.org/10.1515/chempap-2016-0078
Autor:
Milan Stefek, Lucia Kovacikova, Ahmet Cumaoğlu, Murat Kartal, Ali Rifat Gürpinar, Ivana Milackova, Çimen Karasu
Publikováno v:
Interdisciplinary Toxicology
Aldose reductase inhibitory activity and antioxidant capacity of pomegranate extractsThe pomegranate,Punica granatumL., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present study, pom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cec87f1e49bb6cabc5db5dbb55a425d
https://doi.org/10.2478/v10102-012-0003-8
https://doi.org/10.2478/v10102-012-0003-8
Autor:
Lucia Kovacikova, Miroslav Veverka, Marta Soltesova Prnova, Ivana Milackova, Sreeparna Banerjee, Milan Stefek, Magdalena Majekova, Ruzena Sotnikova, Michal Stasko
The ability of flavonoids to affect multiple key pathways of glucose toxicity, as well as to attenuate inflammation has been well documented. In this study, the inhibition of rat lens aldose reductase by 3,7-di-hydroxy-2-[4-(2-chloro-1,4-naphthoquino
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e98dcf3e7012f574a715024ddb34cf
https://aperta.ulakbim.gov.tr/record/82639
https://aperta.ulakbim.gov.tr/record/82639
Autor:
Sreeparna Banerjee, Ivana Milackova, Magdalena Majekova, Marta Soltesova Prnova, Beatriz Díez-Dacal, Muserref Seyma Ceyhan, Milan Stefek, Dolores Pérez-Sala
Publikováno v:
Acta biochimica Polonica. 62(3)
Based on overlapping structural requirements for both efficient aldose reductase inhibitors and PPAR ligands, [5-(benzyloxy)-1H-indol-1-yl]acetic acid (compound 1) was assessed for inhibition of aldose reductase and ability to interfere with PPARγ.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832694da4627fe83c880e828c1390393
https://pubmed.ncbi.nlm.nih.gov/26345091
https://pubmed.ncbi.nlm.nih.gov/26345091
Publikováno v:
General physiology and biophysics. 34(1)
Many natural and synthetic quinones and naphthoquinones possess a variety of beneficial pharmacological properties. In plants, the cytotoxic properties of quinones serve in their defensive roles against invading bacteria, fungi and parasites. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ebe44a7d805033fd9e05140c37fac96
https://pubmed.ncbi.nlm.nih.gov/25367759
https://pubmed.ncbi.nlm.nih.gov/25367759
Publikováno v:
Redox report : communications in free radical research. 18(2)
Objectives The subject of this study was the hexahydropyridoindole compound SMe1EC2 with reported antioxidant and neuroprotective effects and low toxicity. In this study, the antioxidant action of SMe1EC2 was investigated in a greater detail in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8072aa5bd878e568187b82baf5de176e
https://pubmed.ncbi.nlm.nih.gov/23582369
https://pubmed.ncbi.nlm.nih.gov/23582369