Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ivana Mejdrová"'
Autor:
Nivedita Sengupta, Marko Jović, Elena Barnaeva, David W. Kim, Xin Hu, Noel Southall, Milan Dejmek, Ivana Mejdrova, Radim Nencka, Adriana Baumlova, Dominika Chalupska, Evzen Boura, Marc Ferrer, Juan Marugan, Tamas Balla
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 683-693 (2019)
The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-kinase (PI4K) enzymes generate PI4P in different membrane compartmen
Externí odkaz:
https://doaj.org/article/140be2b4c8d44d3c8e02d4ac3aa65593
Autor:
Ivana Mejdrová, Jan Dušek, Kryštof Škach, Alžbeta Stefela, Josef Skoda, Karel Chalupský, Klára Dohnalová, Ivona Pavkova, Thales Kronenberger, Azam Rashidian, Lucie Smutná, Vojtěch Duchoslav, Tomas Smutny, Petr Pávek, Radim Nencka
Publikováno v:
Journal of Medicinal Chemistry. 66:2422-2456
Publikováno v:
New J. Chem.. 41:12178-12189
Herein, we report the regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues with hydroxy alkyl chains that mimic the natural C-nucleoside pseudouridine. We developed multiple disparate synthetic procedures and approaches for th
Autor:
Elisabeth Hennes, Herbert Waldmann, Jana Flegel, Ivana Mejdrová, Slava Ziegler, Radim Nencka, Matthias Baumann, Andrei Ursu, Takanari Inoue, Yuta Nihongaki, Lucas Robke, Petra Janning, Hideaki Matsubayashi, Jared Sterneckert, Alexandra Brause, Jan Eickhoff, Lea Kremer, Hans R. Schöler, Susanne Kordes
Publikováno v:
Angewandte Chemie (International Ed. in English)
The Hedgehog (Hh) signaling pathway is crucial for vertebrate embryonic development, tissue homeostasis and regeneration. Hh signaling is upregulated in basal cell carcinoma and medulloblastoma and Hh pathway inhibitors targeting the Smoothened (SMO)
Autor:
Jan Weber, Ivana Mejdrová, Gabriel Birkus, Eliška Procházková, Martin Kögler, Gary Lee, Michal Šála, Hubert Hřebabecký, Radim Nencka, Dmytro Strunin, Helena Mertlíková-Kaiserová, Pavla Plačková
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
We report on an extensive structure–activity relationship study of novel PI4K IIIβ inhibitors. The purine derivative of the potent screening hit T-00127-HEV1 has served as a suitable starting point for a thorough investigat
We report on an extensive structure–activity relationship study of novel PI4K IIIβ inhibitors. The purine derivative of the potent screening hit T-00127-HEV1 has served as a suitable starting point for a thorough investigat
Autor:
David W. Kim, Adriana Baumlova, Evzen Boura, Milan Dejmek, Noel Southall, Juan J. Marugan, Ivana Mejdrová, Marc Ferrer, Radim Nencka, Nivedita Sengupta, Marko Jovic, Xin Hu, Elena Barnaeva, Tamas Balla, Dominika Chalupska
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 683-693 (2019)
The minor phospholipid, phosphatidylinositol 4-phosphate (PI4P), is emerging as a key regulator of lipid transfer in ER-membrane contact sites. Four different phosphatidylinositol 4-kinase (PI4K) enzymes generate PI4P in different membrane compartmen
Autor:
Milan Dejmek, Michal Šála, Eliška Procházková, Ivana Mejdrová, Pavla Plačková, Gabriel Birkus, Martin Kögler, Radim Nencka, Evzen Boura, Hubert Hřebabecký, Adriana Baumlova, Gary Lee, Jan Weber, Dominika Chalupska, Helena Mertlíková-Kaiserová, Rémi Guillon, Dmytro Strunin
Publikováno v:
Journal of Medicinal Chemistry. 58:3767-3793
Phosphatidylinositol 4-kinase IIIβ is a cellular lipid kinase pivotal to pathogenesis of various RNA viruses. These viruses hijack the enzyme in order to modify the structure of intracellular membranes and use them for the construction of functional
Publikováno v:
Journal of medicinal chemistry. 60(1)
The lipid kinase phosphatidylinositol 4-kinase IIIβ (PI4KB) is an essential host factor for many positive-sense single-stranded RNA (+RNA) viruses including human pathogens hepatitis C virus (HCV), Severe acute respiratory syndrome (SARS), coxsackie