Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells

Autor: Juliane Hitzel, Eunjee Lee, Yi Zhang, Sofia Iris Bibli, Xiaogang Li, Sven Zukunft, Beatrice Pflüger, Jiong Hu, Christoph Schürmann, Andrea Estefania Vasconez, James A. Oo, Adelheid Kratzer, Sandeep Kumar, Flávia Rezende, Ivana Josipovic, Dominique Thomas, Hector Giral, Yannick Schreiber, Gerd Geisslinger, Christian Fork, Xia Yang, Fragiska Sigala, Casey E. Romanoski, Jens Kroll, Hanjoong Jo, Ulf Landmesser, Aldons J. Lusis, Dmitry Namgaladze, Ingrid Fleming, Matthias S. Leisegang, Jun Zhu, Ralf P. Brandes

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

During atherosclerosis, endothelial cells release purines in response to oxidized phospholipids. Here, Hitzel et al. show that oxidized phospholipids activate an MTHFD2-regulated gene network in endothelial cells which reprograms amino acid metabolis

Externí odkaz: https://doaj.org/article/4401176dc9754aceb3a9a13dbd4a3e34

TLR2-Dependent Reversible Oxidation of Connexin 43 at Cys260 Modifies Electrical Coupling After Experimental Myocardial Ischemia/Reperfusion

Autor: Erik Bonke, Jochen Roeper, Heinrich Heide, Ivana Josipovic, Lea Schneider, Ilka Wittig, Matthias S. Leisegang, Stefan Dröse, Florian J Raimann, Kai Zacharowski, Juliana Heidler, Elisabeth Tybl, Jan Mersmann, Ralf P. Brandes

Publikováno v: Journal of cardiovascular translational research. 12(5)

We have shown previously that during myocardial ischemia/reperfusion (MI/R), toll-like receptor 2 (TLR2) signaling regulates connexin 43 (Cx43) subcellular localization and function and dampens arrhythmia formation. We aimed to identify sites capable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2741c5f86c0ce241d42cb36ed0650ed
https://pubmed.ncbi.nlm.nih.gov/30963423

Long noncoding RNA MANTIS facilitates endothelial angiogenic function

Autor: Konstantinos Stellos, Ralph T. Schermuly, Stefan Günther, Matthias S. Leisegang, Yuliya Ponomareva, Ilka Wittig, Carsten Künne, Ralf P. Brandes, Lars Maegdefessel, Patrick Hofmann, Christian Fork, Franziska Moll, Stefanie Dimmeler, Jeremy Epah, Reinier A. Boon, Jiong Hu, Chanil Valasarajan, Jens Preussner, Shizuka Uchida, Florian Richter, Mario Looso, Juliana Heidler, Thomas M. Freiman, Francis J. Miller, Soni Savai Pullamsetti, Karl H. Plate, Ivana Josipovic, Matthew J. Miller, Kavi Devraj, Norbert Weissmann, Michel Mittelbronn

Publikováno v: Leisegang, M S, Fork, C, Josipovic, I, Richter, F M, Preussner, J, Hu, J, Miller, M J, Epah, J, Hofmann, P, Günther, S, Moll, F, Valasarajan, C, Heidler, J, Ponomareva, Y, Freiman, T M, Maegdefessel, L, Plate, K H, Mittelbronn, M, Uchida, S, Künne, C, Stellos, K, Schermuly, R T, Weissmann, N, Devraj, K, Wittig, I, Boon, R A, Dimmeler, S, Pullamsetti, S S, Looso, M, Miller, F J & Brandes, R P 2017, ' Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function ', Circulation, vol. 136, no. 1, pp. 65-79 . https://doi.org/10.1161/CIRCULATIONAHA.116.026991
Circulation, 136(1), 65-79. Lippincott Williams and Wilkins

Background: The angiogenic function of endothelial cells is regulated by numerous mechanisms, but the impact of long noncoding RNAs (lncRNAs) has hardly been studied. We set out to identify novel and functionally important endothelial lncRNAs. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0165eb58c767c08185c6762c23b185cc
http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/43910

PAFAH1B1 and the lncRNA NONHSAT073641 maintain an angiogenic phenotype in human endothelial cells

Autor: Jens Preussner, Mario Looso, Christian Fork, Gerd Geisslinger, Dijana Iloska, Nerea Ferreirós, Dominique Thomas, Andrea E. Vasconez, Kim-Kristin Prior, Ralf P. Brandes, Soni Savai Pullamsetti, Matthias S. Leisegang, Sandra Labocha, Carlo Angioni, Dieter Steinhilber, Ivana Josipovic

Publikováno v: Acta physiologica (Oxford, England). 218(1)

AIM Platelet-activating factor acetyl hydrolase 1B1 (PAFAH1B1, also known as Lis1) is a protein essentially involved in neurogenesis and mostly studied in the nervous system. As we observed a significant expression of PAFAH1B1 in the vascular system,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0972d3d7af0fd77621abdad94f4ab69
https://pubmed.ncbi.nlm.nih.gov/27124368

Epigenetic Regulation of Angiogenesis by JARID1B-Induced Repression of HOXA5

Autor: Juliane Hitzel, Kristian Helin, Yuliya Ponomareva, Sandra U. Schmitz, Lunda Gu, Christian Fork, Michael SzeKa Wong, Jiong Hu, Mareike Albert, Matthias S. Leisegang, Ralf P. Brandes, Ingrid Fleming, Shizuka Uchida, Ivana Josipovic, Dieter Steinhilber

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology. 35(7)

Objective— Altering endothelial biology through epigenetic modifiers is an attractive novel concept, which is, however, just in its beginnings. We therefore set out to identify chromatin modifiers important for endothelial gene expression and contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c5334263c25099bc38309ff06c5d8b
https://pubmed.ncbi.nlm.nih.gov/26023081