Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ivana Gazic Smilovic"'
Autor:
Zdenko Časar, Carin C. C. Johansson Seechurn, Antonio Zanotti-Gerosa, Thomas J. Colacot, Ivana Gazic Smilovic
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2691-2697
We have elaborated a two-step catalytic approach to nafoxidine, a key precursor to lasofoxifene. Firstly, an efficient α-arylation of 6-methoxy-3,4-dihydronaphthalen-1(2H)-one with chlorobenzene was developed, which operates at low 0.1 mol% Pd-132 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd9d563cdaeb4a1196b2d7de950eee2c
https://doi.org/10.1016/j.bmc.2018.04.021
https://doi.org/10.1016/j.bmc.2018.04.021
Publikováno v:
Organic Chemistry Frontiers. 4:2311-2322
In this report we present the first successful homogenous asymmetric hydrogenation of heavily hindered and minimally functionalized tetrasubstituted cyclic olefins bearing three aromatic substituents, which represent key precursors of lasofoxifene ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60cb2861741956965f0df79879cf22c3
https://doi.org/10.1039/c7qo00525c
https://doi.org/10.1039/c7qo00525c
Autor:
Gerhard Laus, Frank Richter, Erwin Schreiner, Jerome Cluzeau, Ivana Gazic Smilovic, Sven Nerdinger, Herwig Schottenberger
Publikováno v:
Bioorganicmedicinal chemistry. 26(9)
Acylation of enantiomerically pure (R)-2-(3-chlorophenyl)propan-1-amine using chloroacetyl chloride, followed by borane reduction and aluminum chloride catalyzed cyclization yielded enantiopure lorcaserin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f9d6203c47eda9e12c704a42fce973
https://pubmed.ncbi.nlm.nih.gov/29496415
https://pubmed.ncbi.nlm.nih.gov/29496415
Publikováno v:
Synthesis. 46:2333-2346
An expedient and simple synthetic approach to pitavastatin and rosuvastatin final intermediates is described. The presented approach consists of completely stereoselective Julia–Kocienski olefination step (E/Z up to 300:1) between lactonized stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc733986048112939c1e55f15fe11338
https://doi.org/10.1055/s-0033-1338648
https://doi.org/10.1055/s-0033-1338648
Publikováno v:
Tetrahedron. 70:2654-2660
In this paper we report the first chemoselective asymmetric hydrogenation of (1-bromo-1-alkenyl)boronic esters, which constitutes a new route to (α-bromoalkyl)boronic esters. The study demonstrates that excellent chemoselectivities along with full c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc8a4782255bd9c7e6044ebdfe9f9d5e
https://doi.org/10.1016/j.tet.2014.02.065
https://doi.org/10.1016/j.tet.2014.02.065
Autor:
Thomas Gelbrich, Sandro Neuner, Klaus Wurst, Herwig Schottenberger, Ivana Gazic Smilovic, Sven Nerdinger
Publikováno v:
HETEROCYCLES. 99:1423
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87f59842acab8908a4ee28c9a02d68eb
https://doi.org/10.3987/com-18-s(f)90
https://doi.org/10.3987/com-18-s(f)90
Autor:
Stephen J. Roseblade, Ulrike Nettekoven, Antonio Zanotti-Gerosa, Ivana Gazic Smilovic, Eva Casas‐Arce, Zdenko Časar
Publikováno v:
Synthesis. 45:2824-2831
Chiral (α-chloroalkyl)boronic esters are obtained by homogeneous asymmetric iridium-catalyzed chemoselective hydrogenation of (1-chloro-1-alkenyl)boronic esters. P,N–Iridium catalysis provides low level of dehalogenation during the hydrogenation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::422eea5acd50ce036a2a03534f4d0db9
https://doi.org/10.1055/s-0033-1338512
https://doi.org/10.1055/s-0033-1338512
Publikováno v:
Synthesis. 44:1700-1710
A concise and simple synthetic route to pitavastatin is described. The approach involves a highly stereoselective Wittig olefination reaction between a lactonized statin side-chain precursor and the triphenylphosphonium bromide salt of the correspond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::483ecdccf58f93e84ea698ed6a313090
https://doi.org/10.1055/s-0031-1290916
https://doi.org/10.1055/s-0031-1290916
Autor:
Eva Casas-Arcé, Ulrike Nettekoven, Antonio Zanotti-Gerosa, Stephen Roseblade, Zdenko Časar, Miroslav Kovacevic, Ivana Gazic Smilovic
Publikováno v:
Angewandte Chemie International Edition. 51:1014-1018
Organoboron compounds play important roles in chemistry, especially in the field of organometallic catalysis where boronic acids, boronic esters, and trifluoroborates are invaluable for the construction of C O, C N, or C C bonds through various coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d73f738f9e00ef0e6c4fb71e0c913c32
https://doi.org/10.1002/anie.201106262
https://doi.org/10.1002/anie.201106262
Publikováno v:
ChemInform. 45
A new methodology for the synthesis of the rarely described title compounds (I) is presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54250d604926a326dd217f6c357de1fe
https://doi.org/10.1002/chin.201435190
https://doi.org/10.1002/chin.201435190