Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ivana Drienovská"'
Publikováno v:
Lugtenburg, T, Gran-Scheuch, A & Drienovská, I 2023, ' Non-canonical amino acids as a tool for the thermal stabilization of enzymes ', Protein Engineering, Design and Selection, vol. 36, gzad003, pp. 1-10 . https://doi.org/10.1093/protein/gzad003
Biocatalysis has become a powerful alternative for green chemistry. Expanding the range of amino acids used in protein biosynthesis can improve industrially appealing properties such as enantioselectivity, activity and stability. This review will spe
Publikováno v:
Hanreich, S, Bonandi, E & Drienovská, I 2023, ' Design of Artificial Enzymes : Insights into Protein Scaffolds ', ChemBioChem, vol. 24, no. 6, e202200566, pp. 1-18 . https://doi.org/10.1002/cbic.202200566
The design of artificial enzymes has emerged as a promising tool for the generation of potent biocatalysts able to promote new-to-nature reactions with improved catalytic performances, providing a powerful platform for wide-ranging applications and a
Publikováno v:
ACS Catalysis, 11(12), 6763-6770. AMER CHEMICAL SOC
ACS Catalysis
ACS Catalysis
The construction and engineering of artificial enzymes consisting of abiological catalytic moieties incorporated into protein scaffolds is a promising strategy to realize non-natural mechanisms in biocatalysis. Here, we show that incorporation of the
Autor:
Carl P. O. Helmer, Elia Calderini, Robert Kourist, Loreto P. Parra, Volker Sieber, Andrea M Chánique, Mónica P. Pantín, Bernhard Loll, Michael Hofer, Nicole Dimos, Ivana Drienovská
Publikováno v:
Chemcatchem
The development of sustainable processes for the valorization of byproducts and other waste streams remains an ongoing challenge in the field of catalysis. Racemic borneol, isoborneol and camphor are currently produced from α‐pinene, a side produc
Publikováno v:
Drienovská, I, Scheele, R A, Gutiérrez de Souza, C & Roelfes, G 2020, ' A Hydroxyquinoline-Based Unnatural Amino Acid for the Design of Novel Artificial Metalloenzymes ', ChemBioChem, vol. 21, no. 21, pp. 3077-3081 . https://doi.org/10.1002/cbic.202000306
ChemBioChem, 21(21), 3077-3081. WILEY-V C H VERLAG GMBH
ChemBioChem, 21(21), 3077-3081. Wiley-VCH Verlag
Chembiochem
ChemBioChem, 21(21), 3077-3081. WILEY-V C H VERLAG GMBH
ChemBioChem, 21(21), 3077-3081. Wiley-VCH Verlag
Chembiochem
We have examined the potential of the noncanonical amino acid (8‐hydroxyquinolin‐3‐yl)alanine (HQAla) for the design of artificial metalloenzymes. HQAla, a versatile chelator of late transition metals, was introduced into the lactococcal multid
Autor:
Matúš Gajdoš, Mahsa Takhtehchian, Uwe T. Bornscheuer, Robert Kourist, Alexia Kindler, Ruth Birner-Gruenberger, Barbara Darnhofer, Ivana Drienovská, Mark Dörr
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Drienovská, I, Gajdoš, M, Kindler, A, Takhtehchian, M, Darnhofer, B, Birner-Gruenberger, R, Dörr, M, Bornscheuer, U T & Kourist, R 2020, ' Folding Assessment of Incorporation of Noncanonical Amino Acids Facilitates Expansion of Functional-Group Diversity for Enzyme Engineering ', Chemistry-A European Journal, vol. 26, no. 54, pp. 12338-12342 . https://doi.org/10.1002/chem.202002077
Chemistry-A European Journal, 26(54), 12338-12342. Wiley-VCH Verlag
Drienovská, I, Gajdoš, M, Kindler, A, Takhtehchian, M, Darnhofer, B, Birner-Gruenberger, R, Dörr, M, Bornscheuer, U T & Kourist, R 2020, ' Folding Assessment of Incorporation of Noncanonical Amino Acids Facilitates Expansion of Functional-Group Diversity for Enzyme Engineering ', Chemistry-A European Journal, vol. 26, no. 54, pp. 12338-12342 . https://doi.org/10.1002/chem.202002077
Chemistry-A European Journal, 26(54), 12338-12342. Wiley-VCH Verlag
Protein design is limited by the diversity of functional groups provided by the canonical protein „building blocks“. Incorporating noncanonical amino acids (ncAAs) into enzymes enables a dramatic expansion of their catalytic features. For this, q
Autor:
Robert Kourist, Kamela Myrtollari, Michael Hofer, Ivana Drienovská, Michaela Pressnig, Elia Calderini, Volker Sieber, Helmut Schwab
Publikováno v:
Chembiochem
ChemBioChem
ChemBioChem
Racemic camphor and isoborneol are readily available as industrial side products, whereas (1R)‐camphor is available from natural sources. Optically pure (1S)‐camphor, however, is much more difficult to obtain. The synthesis of racemic camphor fro
Autor:
Ivana Drienovská, Gerard Roelfes
Publikováno v:
Nature Catalysis, 3(3), 193-202. Nature Publishing Group
The emergence of robust methods to expand the genetic code allows incorporation of non-canonical amino acids into the polypeptide chain of proteins, thus making it possible to introduce unnatural chemical functionalities in enzymes. In this Perspecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c217e6f935080539ebe7f3ac996ee719
https://research.rug.nl/en/publications/e7b6cc63-f073-4a49-8e6c-e7d7e3a25acf
https://research.rug.nl/en/publications/e7b6cc63-f073-4a49-8e6c-e7d7e3a25acf
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
Publikováno v:
Nature Chemistry, 10(9), 946-952. Nature Publishing Group
Nature Chemistry
Nature Chemistry
Creating designer enzymes with the ability to catalyse abiological transformations is a formidable challenge. Efforts toward this goal typically consider only canonical amino acids in the initial design process. However, incorporating unnatural amino
Autor:
Volker Sieber, Kamela Myrtollari, Michaela Pressnig, Helmut Schwab, Elia Calderini, Michael Hofer, Robert Kourist, Ivana Drienovská
Publikováno v:
ChemBioChem. 22:2908-2908