Lipid profiling analyses from mouse models and human infants

Autor: Laurentya Olga, Ivana Bobeldijk-Pastorova, Richard C. Bas, Florine Seidel, Stuart G. Snowden, Samuel Furse, Ken K. Ong, Robert Kleemann, Albert Koulman

Publikováno v: STAR Protocols, Vol 3, Iss 4, Pp 101679- (2022)

Summary: This protocol outlines a translational lipidomic approach to discover lipid biomarkers that could predict morphometric body and histological organ measurements (e.g., weight and adiposity gains) during specific stages of life (e.g., early li

Externí odkaz: https://doaj.org/article/4a2efa5f1bb348948df4b9821b6276ea

Krill Oil Treatment Increases Distinct PUFAs and Oxylipins in Adipose Tissue and Liver and Attenuates Obesity-Associated Inflammation via Direct and Indirect Mechanisms

Autor: Eveline Gart, Kanita Salic, Martine C. Morrison, Martien Caspers, Wim van Duyvenvoorde, Marieke Heijnk, Martin Giera, Ivana Bobeldijk-Pastorova, Jaap Keijer, Andreas B. Storsve, Petter-Arnt Hals, Robert Kleemann

Publikováno v: Nutrients, Vol 13, Iss 8, p 2836 (2021)

The development of obesity is characterized by the metabolic overload of tissues and subsequent organ inflammation. The health effects of krill oil (KrO) on obesity-associated inflammation remain largely elusive, because long-term treatments with KrO

Externí odkaz: https://doaj.org/article/6a32859722444d61b2f24d8a4391b46e

Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model

Autor: Arianne van Koppen, Lars Verschuren, Anita M. van den Hoek, Joanne Verheij, Martine C. Morrison, Kelvin Li, Hiroshi Nagabukuro, Adalberto Costessi, Martien P.M. Caspers, Tim J. van den Broek, John Sagartz, Cornelis Kluft, Carine Beysen, Claire Emson, Alain J. van Gool, Roel Goldschmeding, Reinout Stoop, Ivana Bobeldijk-Pastorova, Scott M. Turner, Guido Hanauer, Roeland Hanemaaijer

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 5, Iss 1, Pp 83-98.e10 (2018)

The incidence of nonalcoholic steatohepatitis (NASH) is increasing. The pathophysiological mechanisms of NASH and the sequence of events leading to hepatic fibrosis are incompletely understood. The aim of this study was to gain insight into the dynam

Externí odkaz: https://doaj.org/article/592b66b824aa47b5807c7f2ccfe9465f

Sharing lessons learnt across European cardiovascular research consortia

Autor: Jeanette Erdmann, Heribert Schunkert, Marijke Bijker-Schreurs, Ivana Bobeldijk-Pastorova, Lisette de Jong, Jan Albert Kuivenhoven, Alain J. van Gool

Publikováno v: Drug Discovery Today, 4, 25, 787-492
Drug Discovery Today, 25, 4, pp. 787-792
Drug Discovery Today, 25, 787-792

Research consortia in Europe often compete with each other for skills, human and technical resources and, eventually, recognition of the scientific impact of their work. In response to the same EU Horizon2020 call, we received funding for our researc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82536fdb6c077b3d8f625bcd3087cfe
https://doi.org/10.1016/j.drudis.2020.01.009

Krill Oil Treatment Increases Distinct PUFAs and Oxylipins in Adipose Tissue and Liver and Attenuates Obesity-Associated Inflammation via Direct and Indirect Mechanisms

Autor: Petter Arnt Hals, Ivana Bobeldijk-Pastorova, Kanita Salic, Andreas Berg Storsve, Martine C. Morrison, Martin Giera, Wim van Duyvenvoorde, Martien P. M. Caspers, Marieke Heijnk, Robert Kleemann, Eveline Gart, Jaap Keijer

Publikováno v: Nutrients
Nutrients, 13(8). MDPI
Nutrients; Volume 13; Issue 8; Pages: 2836
Nutrients, 13(8)
Nutrients 13 (2021) 8
Nutrients, Vol 13, Iss 2836, p 2836 (2021)

The development of obesity is characterized by the metabolic overload of tissues and subsequent organ inflammation. The health effects of krill oil (KrO) on obesity-associated inflammation remain largely elusive, because long-term treatments with KrO

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4b11e67150d663fb38e4c7f8e2978fd
https://pubmed.ncbi.nlm.nih.gov/34444996