Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Ivana, Apicella"'
Autor:
Siddharth Narendran, Felipe Pereira, Praveen Yerramothu, Ivana Apicella, Shao-bin Wang, Kameshwari Ambati, Shuichiro Hirahara, Younghee Kim, Meenakshi Ambati, Vidya L. Ambati, Peirong Huang, Akhil Varshney, Yosuke Nagasaka, Shinichi Fukuda, Kirstie L. Baker, Kenneth M. Marion, Jan M. Deussing, Srinivas R. Sadda, Bradley D. Gelfand, Jayakrishna Ambati
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We rep
Externí odkaz:
https://doaj.org/article/3b63bb9d0ace4f3fbe816152ffbe4d39
Autor:
Peirong Huang, Claire C. Thomas, Kameshwari Ambati, Roshni Dholkawala, Ayami Nagasaka, Praveen Yerramothu, Siddharth Narendran, Felipe Pereira, Yosuke Nagasaka, Ivana Apicella, Xiaoyu Cai, Ryan D. Makin, Joseph Magagnoli, Cliff I. Stains, Ruwen Yin, Shao-bin Wang, Bradley D. Gelfand, Jayakrishna Ambati
Publikováno v:
Investigative Opthalmology & Visual Science. 64:3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1430eb3d8ddd98410e7507689a9bb64a
https://doi.org/10.1167/iovs.64.5.3
https://doi.org/10.1167/iovs.64.5.3
Autor:
Vidya L. Ambati, Ivana Apicella, Srinivas R. Sadda, Peirong Huang, Akhil Varshney, Nagaraj Kerur, Shaobin Wang, Meenakshi Ambati, Felipe Pereira, Siddharth Narendran, Kameshwari Ambati, Kirstie Baker, Yosuke Nagasaka, Dionne Argyle, Bo Liu, Bradley D. Gelfand, Kenneth M. Marion, Tamer Sallam, Scott W. Canna, Kartik Gupta, Praveen Yerramothu, Jayakrishna Ambati, Shuichiro Hirahara, David R. Hinton
Publikováno v:
Science Immunology. 6
Detection of microbial products by multiprotein complexes known as inflammasomes is pivotal to host defense against pathogens. Nucleotide-binding domain leucine-rich repeat (NLR) CARD domain containing 4 (NLRC4) forms an inflammasome in response to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9dae64677cc0a97a7ae747b43001eab
https://doi.org/10.1126/sciimmunol.abi4493
https://doi.org/10.1126/sciimmunol.abi4493
Autor:
Peirong Huang, Siddharth Narendran, Felipe Pereira, Shinichi Fukuda, Yosuke Nagasaka, Ivana Apicella, Praveen Yerramothu, Kenneth M. Marion, Xiaoyu Cai, Srinivas R. Sadda, Bradley D. Gelfand, Jayakrishna Ambati
PurposeSubretinal injection (SRI) in mice is widely used in retinal research, yet the learning curve (LC) of this surgically challenging technique is unknown.MethodsTo evaluate the LC for SRI in a murine model, we analyzed training data from 3 clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e6acc5f67c1f7ff2836e28e61c7592d
https://doi.org/10.1101/2021.11.05.467533
https://doi.org/10.1101/2021.11.05.467533
Autor:
Shuichiro Hirahara, Tetsuro Oshika, Siddharth Narendran, J. Ignacio Aguirre, Shinichi Fukuda, Meenakshi Ambati, Benjamin J. Fowler, Praveen Yerramothu, Bradley D. Gelfand, David R. Hinton, Jayakrishna Ambati, Gerald G. Schumann, Ulrike Held, Yosuke Nagasaka, Felipe Pereira, Kirstie Baker, Nagaraj Kerur, Srinivas R. Sadda, Sanford H. Feldman, Shaobin Wang, Akhil Varshney, Peirong Huang, Ryan D. Makin, Kameshwari Ambati, Vera L. Bonilha, Mo Wang, Tetsuhiro Yasuma, Reo Yasuma, Vidya L. Ambati, Elmira Baghdasaryan, Xiwen Huang, Hiroko Terasaki, Daipayan Banerjee, Ivana Apicella, Kenneth M. Marion, Genrich V. Tolstonog, Yuichiro Ogura, Deepak Bhattarai, Kyung Bo Kim
Publikováno v:
Science advances, 7(40):eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Science Advances
Science advances, vol. 7, no. 40, pp. eabj3658
Description
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Endogenous Alu cDNA triggers inflammasome-mediated cell death in age-related macular degeneration.
Long interspersed nuclear element-1 (L1)–mediated reverse transcription (RT) of Alu RNA into cytoplasmic Alu complementary DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76950f2faadbc056f974ac06c1a507
https://doi.org/10.1126/sciadv.abj3658
https://doi.org/10.1126/sciadv.abj3658
Autor:
S Scott Sutton, Cliff I. Stains, Mehrdad Shadmehr, Peirong Huang, Felipe Pereira, Ethan Will Taylor, Bradley D. Gelfand, Srinivas R. Sadda, Akhil Varshney, Meenakshi Ambati, Joseph Magagnoli, Shaobin Wang, Brian C. Werner, Yosuke Nagasaka, Hannah Leung, Siddharth Narendran, Kenneth M. Marion, Ivana Apicella, Kirstie Baker
Publikováno v:
Proc Natl Acad Sci U S A
The atrophic form of age-related macular degeneration (dry AMD) affects nearly 200 million people worldwide. There is no Food and Drug Administration (FDA)-approved therapy for this disease, which is the leading cause of irreversible blindness among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb72d2991e0e76db44406a23ae49a8a
https://pubmed.ncbi.nlm.nih.gov/34620711
https://pubmed.ncbi.nlm.nih.gov/34620711
Autor:
Peirong Huang, Siddharth Narendran, Felipe Pereira, Shinichi Fukuda, Yosuke Nagasaka, Ivana Apicella, Praveen Yerramothu, Kenneth M. Marion, Xiaoyu Cai, Srinivas R. Sadda, Bradley D. Gelfand, Jayakrishna Ambati
Publikováno v:
Nature protocols. 17(6)
Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such as nanobeads. Here we describe how to undertake SRI of mice. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd7b339d90162cb3b1b5ee5c4b455b13
https://pubmed.ncbi.nlm.nih.gov/35418688
https://pubmed.ncbi.nlm.nih.gov/35418688
Autor:
Bradley D. Gelfand, Yosuke Nagasaka, Peirong Huang, Kenneth M. Marion, Shaobin Wang, Jayakrishna Ambati, Vidya L. Ambati, Shinichi Fukuda, Kirstie Baker, Srinivas R. Sadda, Siddharth Narendran, Akhil Varshney, Ivana Apicella, Meenakshi Ambati, Jan M. Deussing, Praveen Yerramothu, Felipe Pereira, Younghee Kim, Kameshwari Ambati, Shuichiro Hirahara
Publikováno v:
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-9 (2021)
Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cause of global blindness. We report that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0603e8968fe6efbce84f844c2cff458f
https://doi.org/10.1038/s41392-021-00537-z
https://doi.org/10.1038/s41392-021-00537-z
Autor:
Valeria Tarallo, Sandro De Falco, Remo Sanges, Valeria Cicatiello, Caterina Puglisi, Ivana Apicella, Paola Pignata, Sara Magliacane Trotta
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3896, p 3896 (2021)
International journal of molecular sciences (Online) 22 (2021). doi:10.3390/ijms22083896
info:cnr-pdr/source/autori:Pignata P.; Apicella I.; Cicatiello V.; Puglisi C.; Magliacane Trotta S.; Sanges R.; Tarallo V.; De Falco S./titolo:Prolyl 3-hydroxylase 2 is a molecular player of angiogenesis/doi:10.3390%2Fijms22083896/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
Volume 22
Issue 8
International Journal of Molecular Sciences, Vol 22, Iss 3896, p 3896 (2021)
International journal of molecular sciences (Online) 22 (2021). doi:10.3390/ijms22083896
info:cnr-pdr/source/autori:Pignata P.; Apicella I.; Cicatiello V.; Puglisi C.; Magliacane Trotta S.; Sanges R.; Tarallo V.; De Falco S./titolo:Prolyl 3-hydroxylase 2 is a molecular player of angiogenesis/doi:10.3390%2Fijms22083896/rivista:International journal of molecular sciences (Online)/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:22
Prolyl 3-hydroxylase 2 (P3H2) catalyzes the post-translational formation of 3-hydroxyproline on collagens, mainly on type IV. Its activity has never been directly associated to angiogenesis. Here, we identified P3H2 gene through a deep-sequencing tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99881c19fb5191c2dc2cc6edebd5acf
http://europepmc.org/articles/PMC8069486
http://europepmc.org/articles/PMC8069486
Autor:
Shinichi, Fukuda, Akhil, Varshney, Benjamin J, Fowler, Shao-Bin, Wang, Siddharth, Narendran, Kameshwari, Ambati, Tetsuhiro, Yasuma, Joseph, Magagnoli, Hannah, Leung, Shuichiro, Hirahara, Yosuke, Nagasaka, Reo, Yasuma, Ivana, Apicella, Felipe, Pereira, Ryan D, Makin, Eamonn, Magner, Xinan, Liu, Jian, Sun, Mo, Wang, Kirstie, Baker, Kenneth M, Marion, Xiwen, Huang, Elmira, Baghdasaryan, Meenakshi, Ambati, Vidya L, Ambati, Akshat, Pandey, Lekha, Pandya, Tammy, Cummings, Daipayan, Banerjee, Peirong, Huang, Praveen, Yerramothu, Genrich V, Tolstonog, Ulrike, Held, Jennifer A, Erwin, Apua C M, Paquola, Joseph R, Herdy, Yuichiro, Ogura, Hiroko, Terasaki, Tetsuro, Oshika, Shaban, Darwish, Ramendra K, Singh, Saghar, Mozaffari, Deepak, Bhattarai, Kyung Bo, Kim, James W, Hardin, Charles L, Bennett, David R, Hinton, Timothy E, Hanson, Christian, Röver, Keykavous, Parang, Nagaraj, Kerur, Jinze, Liu, Brian C, Werner, S Scott, Sutton, Srinivas R, Sadda, Gerald G, Schumann, Bradley D, Gelfand, Fred H, Gage, Jayakrishna, Ambati
Publikováno v:
Proc Natl Acad Sci U S A
Alu retroelements propagate via retrotransposition by hijacking long interspersed nuclear element-1 (L1) reverse transcriptase (RT) and endonuclease activities. Reverse transcription of Alu RNA into complementary DNA (cDNA) is presumed to occur exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62beeef8e70aaaf560f034ebc5905abf
https://pubmed.ncbi.nlm.nih.gov/33526699
https://pubmed.ncbi.nlm.nih.gov/33526699