Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ivana, Špaková"'
Autor:
Miroslava Rabajdová, Ivana Špaková, Lukáš Smolko, Michaela Abrahamovská, Barbora Baranovičová, Anna Birková, Janka Vašková, Mária Mareková
Publikováno v:
FEBS Open Bio, Vol 14, Iss 1, Pp 148-157 (2024)
Endometriosis and endometrial cancer are closely related to oxidative stress. However, the direct relationship between copper and zinc levels and oxidative stress in the extracellular and intracellular space remains unclear. The presented study is fo
Externí odkaz:
https://doaj.org/article/1b5ef68142c644ddb499b3345ba05050
Autor:
Gabriela Sabolová, Ivana Špaková, Peter Artimovič, Peter Bohuš, Miroslava Rabajdová, Mária Mareková
Publikováno v:
Cancers, Vol 16, Iss 16, p 2772 (2024)
A characteristic feature of uterine pathologies is a specific change in cell metabolism, which predominantly manifests as a shift in the need for nutrients, thereby directing cells to engage in different angiogenic marker activities. Angiogenesis is
Externí odkaz:
https://doaj.org/article/7906a3103fed4b82a07f3e3ae254a49d
Autor:
Peter Artimovič, Zuzana Badovská, Silvia Toporcerová, Ivana Špaková, Lukáš Smolko, Gabriela Sabolová, Eva Kriváková, Miroslava Rabajdová
Publikováno v:
Cells, Vol 13, Iss 13, p 1081 (2024)
Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a con
Externí odkaz:
https://doaj.org/article/3049c079f7564aba862807bcecd06bf7
Autor:
Miroslava Rabajdová, Ivana Špaková, Zuzana Klepcová, Lukáš Smolko, Michaela Abrahamovská, Peter Urdzík, Mária Mareková
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Endometriosis is a chronic inflammatory disease which increasingly affects young women under 35 years of age and leads to subfertility even infertility. Analysis of the cytotoxic effect of zinc(II) niflumato complex with neocuproine ([Zn(neo
Externí odkaz:
https://doaj.org/article/ddc14f71d5fc4288a7f5bc1a69c646e6
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The innate response of melanocytes to exogenous or endogenous stress stimuli like extreme pH and temperature, metabolite and oxygen deficiency or a high UV dose initiates a cellular stress response. This process activates adaptive processes
Externí odkaz:
https://doaj.org/article/bdba5f8a698d47d0806b9986efbdf9f2
Autor:
Janka Vašková, Zuzana Klepcová, Ivana Špaková, Peter Urdzík, Jana Štofilová, Izabela Bertková, Marek Kľoc, Miroslava Rabajdová
Publikováno v:
Antioxidants, Vol 12, Iss 4, p 907 (2023)
Oxidative stress (OS) has an important role in female reproduction, whether it is ovulation, endometrium decidualization, menstruation, oocyte fertilization, or development andimplantation of an embryo in the uterus. The menstrual cycle is regulated
Externí odkaz:
https://doaj.org/article/8ad70d27598d4204a9f00ac8f71cbec6
Autor:
Silvia Toporcerová, Ivana Špaková, Katarína Šoltys, Zuzana Klepcová, Marek Kľoc, Júlia Bohošová, Karolína Trachtová, Lucia Peterová, Helena Mičková, Peter Urdzík, Mária Mareková, Ondřej Slabý, Miroslava Rabajdová
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1687 (2022)
The increased interest in assisted reproduction through in vitro fertilization (IVF) leads to an urgent need to identify biomarkers that reliably highly predict the success of pregnancy. Despite advances in diagnostics, treatment, and IVF approaches,
Externí odkaz:
https://doaj.org/article/aa2e4a728cb74e21a65ee3fc59700b80
Autor:
Ivana Špaková, Miroslava Rabajdová, Katarína Dubayová, Vladimíra Nagyová, Martina Bago Pilátová, Mária Mareková
Publikováno v:
Practical Laboratory Medicine, Vol 22, Iss , Pp e00182- (2020)
Objective: Increasing HIFs in malignant melanoma, the highly aggressive skin tumour, results in the stimulation of invasiveness. Increased HIF-1α fallouts in inhibition of the activity of some mitochondrial enzymes and leads to preference of cytosol
Externí odkaz:
https://doaj.org/article/284d891bfc064e14bf25a62595b24f0e
Autor:
Zuzana Klepcová, Ivana Špaková, Corina T. Madreiter-Sokolowski, Wolfgang Graier, Katarína Kalinová, Erika Samoľová, Romana Smolková, Lukáš Smolko, Miroslava Rabajdová
Publikováno v:
New Journal of Chemistry.
Two isostructural complexes [Mn(neo)(fen)2] (1) and [Mn(neo)(flu)2] (2) show different biological activity on endometrial cell lines. Flufenamato complex effectively triggers apoptosis mediated by caspase activation in endometriotic 12Z cell line.
Publikováno v:
Open Chemistry, Vol 18, Iss 1, Pp 898-910 (2020)
Malignant melanoma (MM) is a cancerous transformation of melanocytes. It is a disease with the worst response to therapy and, compared to other malignancies, presents much earlier with metastases. MM still belongs to relatively late-detected malignan