Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ivan del Barco Barrantes"'
Autor:
Ivan del Barco Barrantes, Camille Stephan-Otto Attolini, Konstantin Slobodnyuk, Ana Igea, Sara Gregorio, Sylwia Gawrzak, Roger R. Gomis, Angel R. Nebreda
Publikováno v:
Stem Cell Reports, Vol 10, Iss 1, Pp 257-271 (2018)
Summary: Mammary stem and progenitor cells are essential for mammary gland homeostasis and are also candidates for cells of origin of mammary tumors. Here, we have investigated the function of the protein kinase p38α in the mammary gland using mice
Externí odkaz:
https://doaj.org/article/1cdcb52fea14446297d22a6b3b3be2a8
Autor:
Petra Mikolcevic, Michitaka Isoda, Hiroki Shibuya, Ivan del Barco Barrantes, Ana Igea, José A. Suja, Sue Shackleton, Yoshinori Watanabe, Angel R. Nebreda
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
CDKs play central roles in cell cycle regulation and are normally activated by cyclins. Here the authors show that RingoA induces a cyclin-independent function of CDK2 at meiotic telomeres, which regulates their tethering to the nuclear envelope and
Externí odkaz:
https://doaj.org/article/b5fefa9e561b4571b7f90454d487e1a7
Autor:
Sarah Ross, Michael Niedbala, Sabina Cosulich, Zoe Underwood, Eleanor Wigmore, Alison Peter, Carla P. Martins, Lukasz Magiera, Jason G. Kettle, Giovanni Ciotta, Ivan del Barco Barrantes, Tamara Baker, James Atkinson, Alex Koers, Rebecca Whiteley, Radoslaw Polanski, Michael Davies, Sue Bickerton, Hilary Lewis, David Robinson, Lyndsey Hanson, Atanu Chakraborty
Supplementary Data from AZD4625 is a Potent and Selective Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0af8725b786ab7b470d22cf3bb924324
https://doi.org/10.1158/1535-7163.22523586.v1
https://doi.org/10.1158/1535-7163.22523586.v1
Autor:
Sarah Ross, Michael Niedbala, Sabina Cosulich, Zoe Underwood, Eleanor Wigmore, Alison Peter, Carla P. Martins, Lukasz Magiera, Jason G. Kettle, Giovanni Ciotta, Ivan del Barco Barrantes, Tamara Baker, James Atkinson, Alex Koers, Rebecca Whiteley, Radoslaw Polanski, Michael Davies, Sue Bickerton, Hilary Lewis, David Robinson, Lyndsey Hanson, Atanu Chakraborty
Supplementary Figure from AZD4625 is a Potent and Selective Inhibitor of KRASG12C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040a8dea15a3d11c94aef8426fadb286
https://doi.org/10.1158/1535-7163.22523583
https://doi.org/10.1158/1535-7163.22523583
Autor:
James T. Lynch, Shaun Moore, Ivan Del Barco Barrantes, Lauren Bradshaw, Chris Chambers, Ted Hong, Sophie Cooke, Jelena Urosevic, Mercedes Vazquez-Chantada, James M. Smith, Anna Cronin, Benedicte Recolin, Sonja Gill, Susan Critchlow, Ho Man Chan, Emma Dean
Publikováno v:
Cancer Research. 83:6272-6272
Background: PRMT5 is an epigenetic enzyme that catalyzes symmetric dimethylation of arginine substrates (SDMA), regulating multiple cell processes. The PRMT5-MTAP collateral vulnerability describes the accumulation of the metabolite methylthioadenosi
Autor:
Atanu Chakraborty, Lyndsey Hanson, David Robinson, Hilary Lewis, Sue Bickerton, Michael Davies, Radoslaw Polanski, Rebecca Whiteley, Alex Koers, James Atkinson, Tamara Baker, Ivan del Barco Barrantes, Giovanni Ciotta, Jason G. Kettle, Lukasz Magiera, Carla P. Martins, Alison Peter, Eleanor Wigmore, Zoe Underwood, Sabina Cosulich, Michael Niedbala, Sarah Ross
Publikováno v:
Molecular cancer therapeutics. 21(10)
AZD4625 is a potent, selective, and orally bioavailable inhibitor of oncogenic KRASG12C as demonstrated in cellular assays and in vivo in preclinical cell line–derived and patient-derived xenograft models. In vitro and cellular assays have shown se
Autor:
Baoqi Yu, Zhongyi Zhang, Yun Zhang, Christof Niehrs, Qiang Zhao, Mei Mei Wong, Claire M.F. Potter, Zhihong Wang, Chungang Zhai, Russell Simpson, Deling Kong, Yanhua Hu, Cheng Zhang, Qingbo Xu, Xiaocong Wang, Ivan del Barco Barrantes, Lei Qiao, Eirini Karamariti
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:425-437
Objective— DKK3 (dickkopf 3), a 36-kD secreted glycoprotein, has been shown to be involved in the differentiation of partially reprogrammed cells and embryonic stem cells to smooth muscle cells (SMCs), but little is known about its involvement in v
Autor:
Marc Guiu, Konstantin Slobodnyuk, Roger R. Gomis, Anna Arnal-Estapé, Cristina Saura, Violeta Serra, Sylwia Gawrzak, Enrique J. Arenas, Ivan del Barco Barrantes, Rianne Groeneveld, Aleix Prat, Marta Palafox, Salvador Aznar Benitah, Anna Bellmunt, Juan Miguel Cejalvo, Ana Lluch, Sara Gregorio, Antonio Berenguer-Llergo, Joaquín Arribas, Ana Rovira, Javier Cortes, Daniela Kalafatovic, Cristina Figueras-Puig, Jelena Urosevic, Angel R. Nebreda, Barbara Müllauer, Camille Stephan-Otto Attolini, Esther Fernández, Fernando Salvador, Lorenzo Rinaldi, Montse Muñoz, Federico Rojo, Joan Albanell, Aikaterini Symeonidi
Publikováno v:
NATURE CELL BIOLOGY
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
For many patients with breast cancer, symptomatic bone metastases appear after years of latency. How micrometastatic lesions remain dormant and undetectable before initiating colonization is unclear. Here, we describe a mechanism involved in bone met
Autor:
Wen Wang, Siegfried Weger, Agnes Mayr, Ivan del Barco Barrantes, Baoqi Yu, Zhongyi Zhang, Stefan Kiechl, Alexandra Le Bras, Eirini Karamariti, Dan Qi, Yanting Song, Georg Schett, Christof Niehrs, Yanhua Hu, Aijuan Qu, Johann Willeit, Qingbo Xu, Xiaochong Wang
Publikováno v:
Circulation
Yu, B, Kiechl, S, Qi, D, Wang, X, Song, Y, Weger, S, Mayr, A, Le Bras, A, Karamariti, E, Zhang, Z, del Barco Barrantes, I, Niehrs, C, Schett, G, Hu, Y, Wang, W, Willeit, J, Qu, A & Xu, Q 2017, ' A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective ', Circulation (Baltimore), vol. 136, no. 11, pp. 1022-1036 . https://doi.org/10.1161/CIRCULATIONAHA.117.027690
Yu, B, Kiechl, S, Qi, D, Wang, X, Song, Y, Weger, S, Mayr, A, Le Bras, A, Karamariti, E, Zhang, Z, del Barco Barrantes, I, Niehrs, C, Schett, G, Hu, Y, Wang, W, Willeit, J, Qu, A & Xu, Q 2017, ' A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective ', Circulation (Baltimore), vol. 136, no. 11, pp. 1022-1036 . https://doi.org/10.1161/CIRCULATIONAHA.117.027690
Supplemental Digital Content is available in the text.
Background: Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is kn
Background: Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is kn
Autor:
Michitaka Isoda, Sue Shackleton, Ivan del Barco Barrantes, Petra Mikolcevic, Hiroki Shibuya, Ana Igea, Angel R. Nebreda, José A. Suja, Yoshinori Watanabe
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cyclin-dependent kinases (CDKs) play key roles in cell cycle regulation. Genetic analysis in mice has revealed an essential role for Cdk2 in meiosis, which renders Cdk2 knockout (KO) mice sterile. Here we show that mice deficient in RingoA, an atypic