Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Ivan Zlatev"'
Autor:
Megha Subramanian, James McIninch, Ivan Zlatev, Mark K. Schlegel, Charalambos Kaittanis, Tuyen Nguyen, Saket Agarwal, Timothy Racie, Martha Arbaiza Alvarado, Kelly Wassarman, Thomas S. Collins, Tyler Chickering, Christopher R. Brown, Karyn Schmidt, Adam B. Castoreno, Svetlana Shulga-Morskaya, Elena Stamenova, Kira Buckowing, Daniel Berman, Joseph D. Barry, Anna Bisbe, Martin A. Maier, Kevin Fitzgerald, Vasant Jadhav
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.
Externí odkaz:
https://doaj.org/article/0fc8fb8623c24daabbd0601f2495d2bc
Autor:
Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga-Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie D. Keirstead, Martin A. Maier, Vasant Jadhav
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A subset of chemically-modified siRNAs conjugated to trivalent GalNAc may fail during nonclinical development due to rat hepatotoxicity. Here, the authors show that hepatotoxicity may be accounted for by microRNA-like off-target effects of siRNA and
Externí odkaz:
https://doaj.org/article/c6e811a8256f42f19ee8c93f99cf1382
Autor:
Wei Hao, Justyna Aleksandra Wojdyla, Rong Zhao, Ruiyun Han, Rajat Das, Ivan Zlatev, Muthiah Manoharan, Meitian Wang, Sheng Cui
Publikováno v:
PLoS Pathogens, Vol 13, Iss 6, p e1006474 (2017)
Middle East respiratory syndrome coronavirus (MERS-CoV) remains a threat to public health worldwide; however, effective vaccine or drug against CoVs remains unavailable. CoV helicase is one of the three evolutionary most conserved proteins in nidovir
Externí odkaz:
https://doaj.org/article/3919545fc91340f5b32bc2d6dcc3218a
Autor:
Justin B Lee, Kaixin Zhang, Yuen Yi C Tam, Joslyn Quick, Ying K Tam, Paulo JC Lin, Sam Chen, Yan Liu, Jayaprakash K Nair, Ivan Zlatev, Kallanthottathil G Rajeev, Muthiah Manoharan, Paul S Rennie, Pieter R Cullis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
The androgen receptor plays a critical role in the progression of prostate cancer. Here, we describe targeting the prostate-specific membrane antigen using a lipid nanoparticle formulation containing small interfering RNA designed to silence expressi
Externí odkaz:
https://doaj.org/article/6f4fc54f8a004c18b091a7dfbda75b0a
Autor:
Edwyn O. Cruz‐López, Liwei Ren, Estrellita Uijl, Marian C. Clahsen‐van Groningen, Richard van Veghel, Ingrid M. Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Timothy Rooney, Anne Kasper, Paul Nioi, Don Foster, A. H. Jan Danser
Publikováno v:
British Journal of Pharmacology, 180(1), 80-93. Wiley-Blackwell
Background and Purpose Small interfering RNA (siRNA) targeting liver angiotensinogen lowers blood pressure, but its effects in hypertensive diabetes are unknown. Experimental Approach To address this, TGR (mRen2)27 rats (angiotensin II-dependent hype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6a4fef44c7e318eeb2093a55188ebd
https://pure.eur.nl/en/publications/d406679c-44b9-43f0-b71e-b517c7e3b63a
https://pure.eur.nl/en/publications/d406679c-44b9-43f0-b71e-b517c7e3b63a
Autor:
Krishna Aluri, Swati Gupta, Sarah Leblanc, Martin Egli, Tim Racie, Muthiah Manoharan, Anna Bisbe, Peter Podbevšek, Vasant Jadhav, John Szeto, Christopher R. Brown, Hartmut Jahns, Ivan Zlatev, Dale C. Guenther, Martin Maier, Pawan Kumar, Adam Castoreno, Janez Plavec, Rohan Degaonkar
Publikováno v:
Nucleic Acids Research
In order to achieve efficient therapeutic post-transcriptional gene-silencing mediated by the RNA interference (RNAi) pathway, small interfering RNAs (siRNAs) must be chemically modified. Several supra-RNA structures, with the potential to stabilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167018a6d7eb4c9256520eb519b54171
https://doi.org/10.1093/nar/gkab724
https://doi.org/10.1093/nar/gkab724
Autor:
Anna Bisbe, Martin Maier, Tuyen Nguyen, Martin Egli, Jennifer L. S. Willoughby, Muthiah Manoharan, Ivan Zlatev, Masaaki Akabane-Nakata, Matt Hettinger, Shigeo Matsuda, Hartmut Jahns, Christopher R. Brown, Nate Taneja, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Klaus Charisse
Publikováno v:
Nucleic Acids Research. 50:1221-1240
A critical challenge for the successful development of RNA interference-based therapeutics therapeutics has been the enhancement of their in vivo metabolic stability. In therapeutically relevant, fully chemically modified small interfering RNAs (siRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7817a518e2e48336a3ea2214a83b9799
https://doi.org/10.1093/nar/gkab544
https://doi.org/10.1093/nar/gkab544
Autor:
Krishna Aluri, Scott Waldron, Karyn Schmidt, Maja M. Janas, Elena Castellanos-Rizaldos, Xiumin Liu, Michael Arciprete, Diane Ramsden, Jing Li, Vasant Jadhav, Robin McDougall, Christopher R. Brown, Bahru A. Habtemariam, Dale C. Guenther, Gabriel J. Robbie, Saket Agarwal, Muthiah Manoharan, Akshay Vaishnaw, Ivan Zlatev, Jeffrey Kurz, Jayaprakash K. Nair, Martin Maier, Saeho Chong, Sagar Agarwal, Christopher S. Theile, Steven Liou, Muthusamy Jayaraman, Varun Goel, Kevin Fitzgerald, Christopher MacLauchlin, Klaus Charisse, Joseph A Cichocki, Ju Liu, Yuanxin Xu, Peter F Smith, Jing-Tao Wu, Xuemei Zhang, Yongli Gu
Publikováno v:
Drug Metabolism and Disposition. 50:781-797
Conjugation of oligonucleotide therapeutics, including small interfering ribonucleic acids (siRNAs) or antisense oligonucleotides (ASOs) to N-acetylgalactosamine (GalNAc) ligands has become the primary strategy for hepatocyte-targeted delivery, and w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4ae67a6f9cc6256cba922321905899
https://doi.org/10.1124/dmd.121.000428
https://doi.org/10.1124/dmd.121.000428
Autor:
Mimouna Madaoui, Dhrubajyoti Datta, Kelly Wassarman, Ivan Zlatev, Martin Egli, Bruce S. Ross, Muthiah Manoharan
Publikováno v:
Organic letters. 24(33)
We report a simple, postsynthetic strategy for synthesis of oligonucleotides containing 2,6-diaminopurine nucleotides and 2-aminoadenine conjugates using 2-fluoro-6-amino-adenosine. The strategy allows introduction of 2,6-diaminopurine and other 2-am
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a25fd88684a23d97da5dfa978c00709
https://pubmed.ncbi.nlm.nih.gov/35973215
https://pubmed.ncbi.nlm.nih.gov/35973215
Autor:
Dhrubajyoti Datta, Shohei Mori, Mimouna Madaoui, Kelly Wassarman, Ivan Zlatev, Muthiah Manoharan
Publikováno v:
Organic letters. 24(25)
An aminooxy click chemistry (AOCC) strategy was used to synthesize nucleoside building blocks for incorporation during solid-support synthesis of oligonucleotides to enable bis-homo and bis-hetero conjugation of various biologically relevant ligands.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52596eb0a5ff96e3247d6e71f58374f
https://pubmed.ncbi.nlm.nih.gov/35715221
https://pubmed.ncbi.nlm.nih.gov/35715221