Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ivan Zadra"'
Autor:
Etna Abad, Jérémy Sandoz, Gerard Romero, Ivan Zadra, Julia Urgel-Solas, Pablo Borredat, Savvas Kourtis, Laura Ortet, Carlos M. Martínez, Donate Weghorn, Sara Sdelci, Ana Janic
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-25 (2024)
Abstract Background TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the recently ide
Externí odkaz:
https://doaj.org/article/05057dea24dc4caab17c91272a5fc686
Autor:
Ivan Zadra, Senda Jimenez-Delgado, Miquel Anglada-Girotto, Carolina Segura-Morales, Zachary J. Compton, Carsten Janke, Luis Serrano, Verena Ruprecht, Isabelle Vernos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors show that polyglutamylation of spindle microtubules is essential for error-free chromosome segregation and is mediated through Tubulin Tyrosine Ligase Like 11 (TTLL11), which is found to be frequently downregulated in cancer.
Externí odkaz:
https://doaj.org/article/c59e82c185544651a5ca231bbf2ff9fa
Autor:
Ivan Zadra, Senda Jimenez-Delgado, Miquel Anglada-Girotto, Carolina Segura-Morales, Zachary J. Compton, Carsten Janke, Luis Serrano, Verena Ruprecht, Isabelle Vernos
Publikováno v:
Nature communications. 13(1)
Regulation of microtubule (MT) dynamics is key for mitotic spindle assembly and faithful chromosome segregation. Here we show that polyglutamylation, a still understudied post-translational modification of spindle MTs, is essential to define their dy