Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Ivan Vulovic"'
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assembli
Externí odkaz:
https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
Autor:
Vicki H. Wysocki, Grant J. Jensen, David Baker, Andrew Norris, Alexis Courbet, Florian Busch, David Veesler, George Ueda, Ivan Vulovic, Qing Yao, Danny D. Sahtoe, Andreas Plückthun, Robert A. Langan, Yang Hsia, Jorge A. Fallas, Hannes Merten, Sara J. Weaver, Aniruddha Sahasrabuddhe, Young-Jun Park
Publikováno v:
Proc Natl Acad Sci U S A
Protein nanomaterial design is an emerging discipline with applications in medicine and beyond. A longstanding design approach uses genetic fusion to join protein homo-oligomer subunits via α-helical linkers to form more complex symmetric assemblies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd5f4ad2eca40ff24ac5952642a62d2
https://doi.org/10.5167/uzh-210196
https://doi.org/10.5167/uzh-210196
Autor:
Vicki H. Wysocki, Jonathan Abraham, Donald E. Ingber, David Baker, Inna Goreshnik, Ta-Yi Yu, Lars Clark, Daniel Olal, Nur Mustafaoglu, Danny D. Sahtoe, Adrian Coscia, Florian Busch, Ivan Vulovic, Lance Stewart, Yu-Ru Lin, Lauren Miller
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The de novo design of proteins that bind natural target proteins is useful for a variety of biomedical and biotechnological applications. We describe a design strategy to target proteins containing an exposed beta edge strand. We use the
Autor:
Ivan Vulovic, Cameron M. Chow, Natasha I. Edman, Evelyn Tsai, Yang Hsia, Matthew J. Bick, Alex Kang, Alexis Courbet, William Sheffler, Rubul Mout, Gira Bhabha, Rachel L. Redler, Young-Jun Park, David Veesler, David Baker, Una Nattermann, Damian C. Ekiert, Ayesha Saleem, Asim K. Bera, T. J. Brunette
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
A systematic and robust approach to generating complex protein nanomaterials would have broad utility. We develop a hierarchical approach to designing multi-component protein assemblies from two classes of modular building blocks: designed helical re
Autor:
Neil P. King, L. Stewart, Andrew T. McGuire, David Veesler, David Baker, James Lazarovits, George Ueda, Ha V. Dang, Leah J. Homad, Madeleine F. Jennewein, Robby Divine, Yu Hsin Wan, Daniel J. Campbell, Mitchell L Fahning, Peter A. Morawski, Ali Etemadi, Jorge A. Fallas, Hannele Ruohola-Baker, Julie Mathieu, Shally Saini, Yan Ting Zhao, Alex Roederer, Alexandra C. Walls, Mohammadali Mazloomi, Marti R. Tooley, Franziska Seeger, Leonidas Stamatatos, William Sheffler, Infencia Xavier Raj, Ivan Vulovic
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Science
article-version (status) pre
article-version (number) 1
Science
Antibodies are widely used in biology and medicine, and there has been considerable interest in multivalent antibody formats to increase binding avidity and enhance signaling pathway agonism. However, there are currently no general approaches for for
Autor:
Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, TJ Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
A goal of de novo protein design is to develop a systematic and robust approach to generating complex nanomaterials from stable building blocks. Due to their structural regularity and simplicity, a wide range of monomeric repeat proteins and oligomer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91df8f7682a2a4422e94cd3226ea4762
https://doi.org/10.1101/2020.07.27.221333
https://doi.org/10.1101/2020.07.27.221333
Publikováno v:
Structure. 24(1):187-199
SummaryMost rotamer libraries are generated from subsets of the PDB and do not fully represent the conformational scope of protein side chains. Previous attempts to rectify this sparse coverage of conformational space have involved application of wei
d-amino acids are useful building blocks for de novo peptide design and they play a role in aging-related diseases associated with gradual protein racemization. For amino acids with achiral side chains, one should be able to presume that the conforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1613d068828c17679aedf7dbfd7624c1
https://europepmc.org/articles/PMC4204638/
https://europepmc.org/articles/PMC4204638/