Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ivan Vokřál"'
Autor:
Markéta Zajíčková, Lukáš Prchal, Martina Navrátilová, Nikola Vodvárková, Petra Matoušková, Ivan Vokřál, Linh Thuy Nguyen, Lenka Skálová
Publikováno v:
Veterinary Research, Vol 52, Iss 1, Pp 1-13 (2021)
Abstract Haemonchus contortus is a parasitic nematode of ruminants which causes significant losses to many farmers worldwide. Since the drugs currently in use for the treatment of haemonchosis are losing their effectiveness due to the drug-resistance
Externí odkaz:
https://doaj.org/article/d0fe67f9501b40498e08091c5ef481b1
Autor:
Pavlína Kellerová, Lucie Raisová Stuchlíková, Petra Matoušková, Karolína Štěrbová, Jiří Lamka, Martina Navrátilová, Ivan Vokřál, Barbora Szotáková, Lenka Skálová
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-17 (2020)
Abstract The efficacy of anthelmintic therapy of farm animals rapidly decreases due to drug resistance development in helminths. In resistant isolates, the increased expression and activity of drug-metabolizing enzymes (DMEs), e.g. cytochromes P450 (
Externí odkaz:
https://doaj.org/article/fcef1c6e6dee49ce88c29696feba82c4
Autor:
Petra Matoušková, Lenka Lecová, Roz Laing, Diana Dimunová, Heiko Vogel, Lucie Raisová Stuchlíková, Linh Thuy Nguyen, Pavlína Kellerová, Ivan Vokřál, Jiří Lamka, Barbora Szotáková, Marián Várady, Lenka Skálová
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 420-429 (2018)
UDP-glycosyltransferases (UGT), catalysing conjugation of UDP-activated sugar donors to small lipophilic chemicals, are widespread in living organisms from bacteria to fungi, plant, or animals. The progress of genome sequencing has enabled an assessm
Externí odkaz:
https://doaj.org/article/91d5de2796d44a0da5a5dadbc53bc0ed
Autor:
Markéta Zajíčková, Lukáš Prchal, Ivan Vokřál, Linh Thuy Nguyen, Thomas Kurz, Robin Gasser, Klára Bednářová, Magdalena Mičundová, Beate Lungerich, Oliver Michel, Lenka Skálová
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 754 (2022)
As a widely distributed parasitic nematode of ruminants, Haemonchus contortus has become resistant to most anthelmintic classes, there has been a major demand for new compounds against H. contortus and related nematodes. Recent phenotypic screening h
Externí odkaz:
https://doaj.org/article/7a8893e8873f48b7b980a9f6e1475c6f
Publikováno v:
Pharmaceuticals, Vol 15, Iss 2, p 242 (2022)
The inhibition of P-glycoprotein (ABCB1) could lead to increased drug plasma concentrations and hence increase drug toxicity. The evaluation of a drug’s ability to inhibit ABCB1 is complicated by the presence of several transport-competent sites wi
Externí odkaz:
https://doaj.org/article/a7d669cc018f407d8db99b38117ab3e2
Autor:
Lucie Raisová Stuchlíková, Petra Matoušková, Ivan Vokřál, Jiří Lamka, Barbora Szotáková, Anna Sečkařová, Diana Dimunová, Linh Thuy Nguyen, Marián Várady, Lenka Skálová
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 1, Pp 50-58 (2018)
Haemonchus contortus (family Trichostrongylidae, Nematoda), a hematophagous gastrointestinal parasite found in small ruminants, has a great ability to develop resistance to anthelmintic drugs. We studied the biotransformation of the three benzimidazo
Externí odkaz:
https://doaj.org/article/2503c274010a4fb996178a272d7add6d
Autor:
Luboš Fical, Maria Khalikova, Hana Kočová Vlčková, Ivona Lhotská, Zuzana Hadysová, Ivan Vokřál, Lukáš Červený, František Švec, Lucie Nováková
Publikováno v:
Molecules, Vol 26, Iss 8, p 2123 (2021)
Two new ultra-high performance liquid chromatography (UHPLC) methods for analyzing 21 selected antivirals and their metabolites were optimized, including sample preparation step, LC separation conditions, and tandem mass spectrometry detection. Micro
Externí odkaz:
https://doaj.org/article/6b8de8640dc5401bacf1b41fa7450422
Autor:
Martina Navrátilová, Ivan Vokřál, Josef Krátký, Petra Matoušková, Andrea Sochová, Daniela Vrábľová, Barbora Szotáková, Lenka Skálová
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f63b2340cf08930e2d3e344febc41e0
https://doi.org/10.2139/ssrn.4165550
https://doi.org/10.2139/ssrn.4165550
Autor:
Šadibolová Michaela, Lamka Jiří, Skálová Lenka, Sobotová Dominika, Lokvencová Kateřina, Szotáková Barbora, Ivan Vokřál, Prchal Lukáš, Podlipná Radka
Publikováno v:
Ecotoxicology and Environmental Safety. 169:944-949
Ivermectin (IVM), a macrocylic lactone from the avermectin family, is a potent broad-spectrum anthelmintic drug widely used in veterinary as well as human medicine. Although the health benefits of IVM treatment are particularly important, this drug a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f62f28479c6def92bbb0474b11ffe0fb
https://doi.org/10.1016/j.ecoenv.2018.11.097
https://doi.org/10.1016/j.ecoenv.2018.11.097
Autor:
Diana Dimunová, Petra Matoušková, Martina Navrátilová, Linh Thuy Nguyen, Martin Ambrož, Ivan Vokřál, Barbora Szotáková, Lenka Skálová
Publikováno v:
Science of The Total Environment. 822:153527
Veterinary anthelmintics excreted from treated animals pass to soil, subsequently to plants and then to their consumers. This circulation might have various consequences, including drug-resistance promotion in helminths. The present study was designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d5ceb9c26c52c8948f97ad91c4e9b6
https://doi.org/10.1016/j.scitotenv.2022.153527
https://doi.org/10.1016/j.scitotenv.2022.153527