Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ivan V. Ozerov"'
Autor:
Garik V. Mkrtchyan, Alexander Veviorskiy, Evgeny Izumchenko, Anastasia Shneyderman, Frank W. Pun, Ivan V. Ozerov, Alex Aliper, Alex Zhavoronkov, Morten Scheibye-Knudsen
Publikováno v:
Cell Death and Disease, Vol 13, Iss 11, Pp 1-9 (2022)
Abstract Multiple cancer types have limited targeted therapeutic options, in part due to incomplete understanding of the molecular processes underlying tumorigenesis and significant intra- and inter-tumor heterogeneity. Identification of novel molecu
Externí odkaz:
https://doaj.org/article/8d0e50351b0348ee9424beea95768a36
Autor:
Frank W. Pun, Bonnie Hei Man Liu, Xi Long, Hoi Wing Leung, Geoffrey Ho Duen Leung, Quinlan T. Mewborne, Junli Gao, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evelyne Bischof, Evgeny Izumchenko, Xiaoming Guan, Ke Zhang, Bai Lu, Jeffrey D. Rothstein, Merit E. Cudkowicz, Alex Zhavoronkov
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease with ill-defined pathogenesis, calling for urgent developments of new therapeutic regimens. Herein, we applied PandaOmics, an AI-driven target discovery platform, to analyze th
Externí odkaz:
https://doaj.org/article/d12999749a99465fb2c046587d7bb7ef
Autor:
Jaime L. Chao, Michael Korzinkin, Alex Zhavoronkov, Ivan V. Ozerov, Matthew T. Walker, Kathleen Higgins, Mark W. Lingen, Evgeny Izumchenko, Peter A. Savage
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 9, Pp 100399- (2021)
Summary: Immune suppression by CD4+FOXP3+ regulatory T (Treg) cells and tumor infiltration by CD8+ effector T cells represent two major factors impacting response to cancer immunotherapy. Using deconvolution-based transcriptional profiling of human p
Externí odkaz:
https://doaj.org/article/575b6d1e0b9940b8b161dd4b76e3be1e
Autor:
Esther C. Broner, Jonathan A. Trujillo, Michael Korzinkin, Tejaswini Subbannayya, Nishant Agrawal, Ivan V. Ozerov, Alex Zhavoronkov, Lisa Rooper, Nikita Kotlov, Le Shen, Alexander T. Pearson, Ari J. Rosenberg, Peter A. Savage, Vasudha Mishra, Aditi Chatterjee, David Sidransky, Evgeny Izumchenko
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Despite recent advancements, the 5 year survival of head and neck squamous cell carcinoma (HNSCC) hovers at 60%. DCLK1 has been shown to regulate epithelial-to-mesenchymal transition as well as serving as a cancer stem cell marker in colon, pancreati
Externí odkaz:
https://doaj.org/article/2050f94809f344348709fe437dccb6db
Autor:
Rajani Ravi, Kimberly A. Noonan, Vui Pham, Rishi Bedi, Alex Zhavoronkov, Ivan V. Ozerov, Eugene Makarev, Artem V. Artemov, Piotr T. Wysocki, Ranee Mehra, Sridhar Nimmagadda, Luigi Marchionni, David Sidransky, Ivan M. Borrello, Evgeny Izumchenko, Atul Bedi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Antitumor T cells can be inhibited by a TGFβ rich tumor microenvironment. The authors develop bifunctional proteins comprising CTLA-4 or PD-L1 immune checkpoint-targeted antibodies fused to a “TGFβ trap” and show that they counteract tumor immu
Externí odkaz:
https://doaj.org/article/09ab3fbc9c154b9e985f7d27f5620315
Autor:
Ivan V. Ozerov, Ksenia V. Lezhnina, Evgeny Izumchenko, Artem V. Artemov, Sergey Medintsev, Quentin Vanhaelen, Alexander Aliper, Jan Vijg, Andreyan N. Osipov, Ivan Labat, Michael D. West, Anton Buzdin, Charles R. Cantor, Yuri Nikolsky, Nikolay Borisov, Irina Irincheeva, Edward Khokhlovich, David Sidransky, Miguel Luiz Camargo, Alex Zhavoronkov
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Pathway analysis aids interpretation of large-scale gene expression data, but existing algorithms fall short of providing robust pathway identification. The method introduced here includes coexpression analysis and gene importance estimation to robus
Externí odkaz:
https://doaj.org/article/2c57748e19064775b999e9d5f44aa2b9
Autor:
Polina Mamoshina, Marina Volosnikova, Ivan V. Ozerov, Evgeny Putin, Ekaterina Skibina, Franco Cortese, Alex Zhavoronkov
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
For the past several decades, research in understanding the molecular basis of human muscle aging has progressed significantly. However, the development of accessible tissue-specific biomarkers of human muscle aging that may be measured to evaluate t
Externí odkaz:
https://doaj.org/article/f1f6043a43e944cb82ec3fa55e825912
Autor:
Stepan Ulyanenko, Margarita Pustovalova, Sergey Koryakin, Evgenii Beketov, Anatolii Lychagin, Liliya Ulyanenko, Andrey Kaprin, Anna Grekhova, Alexandra M. Ozerova, Ivan V. Ozerov, Natalia Vorobyeva, Peter Shegay, Sergey Ivanov, Sergey Leonov, Dmitry Klokov, Andreyan N. Osipov
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 11, p 2645 (2019)
DNA double-strand breaks (DSB) are among the most harmful DNA lesions induced by ionizing radiation (IR). Although the induction and repair of radiation-induced DSB is well studied for acute irradiation, responses to DSB produced by chronic IR exposu
Externí odkaz:
https://doaj.org/article/0d301248007c48dcb3e42e6a68d3ebe4
Autor:
Andreyan N. Osipov, Natalya Y. Vorobyeva, Nadezhda M. Smetanina, Ekaterina Y. Arkhangelskaya, Natalya A. Anchishkina, Andrey Y. Bushmanov, Ivan V. Ozerov, Denis V. Guryev, Konstantin V. Kotenko
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 13719-13726 (2013)
A comparative investigation of the induction of double-strand DNA breaks (DSBs) in the Chinese hamster V79 cells by γ-radiation at dose rates of 1, 10 and 400 mGy/min (doses ranged from 0.36 to 4.32 Gy) was performed. The acute radiation exposure at
Externí odkaz:
https://doaj.org/article/145f2a2bb9794532af14baf637ce0b40
Autor:
Feng Ren, Xiao Ding, Min Zheng, Mikhail Korzinkin, Xin Cai, Wei Zhu, Alexey Mantsyzov, Alex Aliper, Vladimir Aladinskiy, Zhongying Cao, Shanshan Kong, Xi Long, Bonnie Hei Man Liu, Yingtao Liu, Vladimir Naumov, Anastasia Shneyderman, Ivan V. Ozerov, Ju Wang, Frank W. Pun, Daniil A. Polykovskiy, Chong Sun, Michael Levitt, Alán Aspuru-Guzik, Alex Zhavoronkov
Publikováno v:
Chemical Science. 14:1443-1452
A novel CDK20 small molecule inhibitor discovered by artificial intelligence based on an AlphaFold-predicted structure demonstrates the first application of AlphaFold in hit identification for efficient drug discovery.