Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ivan V. Chernikov"'
Autor:
Arseny D. Moralev, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
ACS Omega, Vol 8, Iss 51, Pp 48813-48824 (2023)
Externí odkaz:
https://doaj.org/article/97f53e210b5b4b3c8c867f70daf22953
Autor:
Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Cells, Vol 13, Iss 9, p 767 (2024)
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are
Externí odkaz:
https://doaj.org/article/df86cd36ee1a45d0b8013056b41765d0
Autor:
Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 29, Iss 4, p 786 (2024)
Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectiv
Externí odkaz:
https://doaj.org/article/a9812619882e4165812a0c26a5a07816
Autor:
Maxim S. Kupryushkin, Anton V. Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan V. Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii V. Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 211-226 (2022)
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is
Externí odkaz:
https://doaj.org/article/c83f7d0cf88a49389f1c3548b177f3e2
Autor:
Kirill V. Odarenko, Oksana V. Salomatina, Ivan V. Chernikov, Nariman F. Salakhutdinov, Marina A. Zenkova, Andrey V. Markov
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1369 (2023)
Despite the proven tumorigenic effect of leptin on epithelial-derived cancers, its impact on the aggressiveness of neural crest-derived cancers, notably neuroblastoma, remains largely unexplored. In our study, for the first time, transcriptome analys
Externí odkaz:
https://doaj.org/article/bb9693f1040e4e129c5b5696f6b6a6ab
Autor:
Daniil V. Gladkikh, Aleksandra V. Sen′kova, Ivan V. Chernikov, Tatyana O. Kabilova, Nelly A. Popova, Valery P. Nikolin, Elena V. Shmendel, Mikhail A. Maslov, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1252 (2021)
In this study, we examined the in vivo toxicity of the liposomes F consisting of 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride, lipid-helper 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine and folate lipoco
Externí odkaz:
https://doaj.org/article/df1d1da4a6b245aa93611c072a0d6e74
Autor:
Ivan V. Chernikov, Daniil V. Gladkikh, Mariya I. Meschaninova, Alya G. Ven'yaminova, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 209-220 (2017)
Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the car
Externí odkaz:
https://doaj.org/article/a745375785e3445691e0772e40b58dd1
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation. The main problems in the development of siRNA-based drugs for therapeutic use are the low
Externí odkaz:
https://doaj.org/article/8c486dde09ce4b9c8b2b8dd5565edf96
Autor:
Oleg V. Markov, Anton V. Filatov, Maxim S. Kupryushkin, Ivan V. Chernikov, Olga A. Patutina, Anton A. Strunov, Elena L. Chernolovskaya, Valentin V. Vlassov, Dmitrii V. Pyshnyi, Marina A. Zenkova
Publikováno v:
Molecules, Vol 25, Iss 16, p 3663 (2020)
Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies t
Externí odkaz:
https://doaj.org/article/3f5085eb190c47098a7920bdfab5b453
Autor:
Nafisa S. Sirazhetdinova, Victor A. Savelyev, Tatyana S. Frolova, Dmitry S. Baev, Lyubov S. Klimenko, Ivan V. Chernikov, Olga S. Oleshko, Teresa A. Sarojan, Andrey G. Pokrovskii, Elvira E. Shults
Publikováno v:
Molecules, Vol 25, Iss 11, p 2547 (2020)
A series of 1,2-, 1,4-disubstituted or 1,2,4-trisubstituted anthraquinone-based compounds was designed, synthesized, characterized and biologically evaluated for anticancer efficacy. 2- or 4-arylated 1-hydroxy-9,10-antraquinones (anthracene-9,10-dion
Externí odkaz:
https://doaj.org/article/d1e3f57823fc4aa8b0d0bca255cfd9f2