Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ivan Tochitsky"'
Autor:
Jared M. Sprague, Ajay S. Yekkirala, Bhagat Singh, Ivan Tochitsky, Michael Stephens, Octavio Viramontes, Jelena Ivanis, Natalia P. Biscola, Leif A. Havton, Clifford J. Woolf, Alban Latremoliere
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract TRPV1 is an ion channel that transduces noxious heat and chemical stimuli and is expressed in small fiber primary sensory neurons that represent almost half of skin nerve terminals. Tissue injury and inflammation result in the sensitization
Externí odkaz:
https://doaj.org/article/29cb07f8d3904765814dfa76b8f551c4
Autor:
Sergei Nikonov, Natalia Dolgova, Raghavi Sudharsan, Ivan Tochitsky, Simone Iwabe, Jose-Manuel Guzman, Russell N. Van Gelder, Richard H. Kramer, Gustavo D. Aguirre, William A. Beltran
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2711 (2022)
Photopharmacological compounds such as azobenzene-based photoswitches have been shown to control the conductivity of ionic channels in a light-dependent manner and are considered a potential strategy to restore vision in patients with end-stage photo
Externí odkaz:
https://doaj.org/article/5919a5885bde42f29503b6d35b955585
Publikováno v:
Bio-Protocol, Vol 11, Iss 15 (2021)
Primary somatosensory neurons, whose cell bodies reside in the dorsal root ganglion (DRG) and trigeminal ganglion, are specialized to transmit sensory information from the periphery to the central nervous system. Our molecular understanding of periph
Externí odkaz:
https://doaj.org/article/9f409029eeaf41289d22aa48eea59720
Autor:
Clifford J. Woolf, Stephen M. Jordan, Benjamin Doyle, Sébastien Talbot, Jaehoon Shim, Louise Haste, Ivan Tochitsky, Jinbo Lee, Nick Andrews, Bruce D. Levy, David A. Roberson, Masakazu Kotoda, Bruce P. Bean, Sooyeon Jo
Publikováno v:
Br J Pharmacol
Background and Purpose: Many pain-triggering nociceptor neurons express TRPV1 or TRPA1, cation-selective channels with large pores that enable permeation of QX-314, a cationic analogue of lidocaine. Co-application of QX-314 with TRPV1 or TRPA1 activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a36597a19ec1ba1f18b99fb5ac66845
https://pubmed.ncbi.nlm.nih.gov/33988876
https://pubmed.ncbi.nlm.nih.gov/33988876
Publikováno v:
Bio Protoc
Primary somatosensory neurons, whose cell bodies reside in the dorsal root ganglion (DRG) and trigeminal ganglion, are specialized to transmit sensory information from the periphery to the central nervous system. Our molecular understanding of periph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361667feb0ce9278460515f2662004ef
https://pubmed.ncbi.nlm.nih.gov/34458396
https://pubmed.ncbi.nlm.nih.gov/34458396
Autor:
Benjamin Doyle, Ivan Tochitsky, David A. Roberson, Stephen M. Jordan, Louise Haste, Nick Andrews, Sébastien Talbot, Clifford J. Woolf, Bruce D. Levy, Jaehoon Shim, Jinbo Lee, Sooyeon Jo, Bruce P. Bean, Masakazu Kotoda
Although multiple diseases of the respiratory system cause cough, there are few effective treatments for this common condition. We previously developed a strategy to treat pain and itch via the long-lasting inhibition of nociceptor sensory neurons wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::328c541124b5b958edb42c7b7763a1c6
https://doi.org/10.1101/2020.12.07.414763
https://doi.org/10.1101/2020.12.07.414763
Publikováno v:
Chemical Reviews. 118:10748-10773
Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366ecad15ba261df61bb2cbc10256c24
https://doi.org/10.1021/acs.chemrev.7b00723
https://doi.org/10.1021/acs.chemrev.7b00723
Autor:
Min-Joon Han, Deniz Cataltepe, Kellen D. Winden, Clifford J. Woolf, Daria Turner, Mustafa Sahin, Mary E. Hatten, Ville J. Kujala, David E. Buchholz, Kush Kapur, Ivan Tochitsky, Maria Sundberg
Publikováno v:
Molecular psychiatry
Accumulating evidence suggests that cerebellar dysfunction early in life is associated with autism spectrum disorder (ASD), but the molecular mechanisms underlying the cerebellar deficits at the cellular level are unclear. Tuberous sclerosis complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87977593a76cd82aab6c28d06c24f9c2
http://europepmc.org/articles/PMC6093816
http://europepmc.org/articles/PMC6093816
Autor:
Lee L. Rubin, Clifford J. Woolf, Bjoern Schwer, Frederick W. Alt, Devlin Frost, Riki Kawaguchi, Jelena Ivanis, Priscilla Riva, Yung-Chih Cheng, Lance S. Davidow, Michael Costigan, Anthony C. Arvanites, Alyssa Grantham, Andrew Snavely, Eric A. Huebner, Rie Maeda, Ivan Tochitsky, Crystal Herman, Vatsal Oza, Xuefei Zhang, Giovanni Coppola, Bhagat Singh, Lee Barrett, Q. Wang, Kathleen L. Pfaff, Amelia N. Chang, Miyuki Sakuma
Publikováno v:
Cell Reports. 36:109666
Although axonal damage induces rapid changes in gene expression in primary sensory neurons, it remains unclear how this process is initiated. The transcription factor ATF3, one of the earliest genes responding to nerve injury, regulates expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1cd513058920d9d4bb92c0fac0189bf
https://doi.org/10.1016/j.celrep.2021.109666
https://doi.org/10.1016/j.celrep.2021.109666
Autor:
Martin Sumser, Michael B. Manookin, Christian Schön, Ivan Tochitsky, Kuldeep Kaur, Dirk Trauner, David M. Barber, Laura Laprell, Martin Biel, Russell N. Van Gelder, Richard H. Kramer, Stylianos Michalakis, Marco Stein
Publikováno v:
Journal of Clinical Investigation. 127:2598-2611
Photopharmacological control of neuronal activity using synthetic photochromic ligands, or photoswitches, is a promising approach for restoring visual function in patients suffering from degenerative retinal diseases. Azobenzene photoswitches, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f110835376b8c49507340a72f1c3ec82
https://doi.org/10.1172/jci92156
https://doi.org/10.1172/jci92156