Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Ivan Stratov"'
Publikováno v:
Advances in Virology, Vol 2012 (2012)
The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cells can als
Externí odkaz:
https://doaj.org/article/ac3be96b0bd4413a974f91c068cd29f6
Autor:
Leia Wren, Matthew S Parsons, Gamze Isitman, Robert J Center, Anthony D Kelleher, Ivan Stratov, Nicole F Bernard, Stephen J Kent
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38580 (2012)
There is growing interest in HIV-specific antibody-dependent cellular cytotoxicity (ADCC) as an effective immune response to prevent or control HIV infection. ADCC relies on innate immune effector cells, particularly NK cells, to mediate control of v
Externí odkaz:
https://doaj.org/article/baa29293935045dd89fe734dc2191280
Autor:
Ivan Stratov, P. Mark Hogarth, Bruce D. Wines, Janaki Amin, Ester Lopez, Amy W. Chung, Vijaya Madhavi, Sean Emery, Stephen J. Kent, Anthony D. Kelleher
Publikováno v:
Journal of Virology. 91
Studying HIV-infected individuals who control HIV replication (elite controllers [ECs]) enables exploration of effective anti-HIV immunity. HIV Env-specific and non-Env-specific antibody-dependent cellular cytotoxicity (ADCC) may contribute to protec
Autor:
Matthew S. Parsons, Fernanda Ana-Sosa-Batiz, Marit Kramski, Sarah Pett, Ivan Stratov, Sinthujan Jegaskanda, Anthony D. Kelleher, Stephen J. Kent, Jintanat Ananworanich, Vijaya Madhavi, Denise Hsu, Wendy R. Winnall, David A. Cooper
Publikováno v:
Journal of Infectious Diseases. 211:529-538
Background. Combination antiretroviral therapy (cART) effectively controls human immunodeficiency virus (HIV) infection but does not eliminate HIV, and lifelong treatment is therefore required. HIV-specific cytotoxic T lymphocyte (CTL) responses decl
Publikováno v:
Vaccine. 31:5506-5517
A safe and effective vaccine against HIV is a global health priority. Large-scale phase III clinical vaccine trials based on neutralizing antibodies and cytotoxic T-lymphocytes have failed to provide protection, highlighting the lack of understanding
Publikováno v:
Current HIV Research. 11:388-406
The partial success of the RV144 trial re-energized the field of HIV vaccine research, which had stalled after vaccines based on neutralizing antibody and cytotoxic T cells had failed to induce protection. A large post-vaccine research effort has foc
Autor:
Gamze Isitman, Marjon Navis, Ivan Stratov, Vijaya Madhavi, Robert De Rose, Stephen J. Kent, Amy W. Chung, Leia Wren
Publikováno v:
Human Vaccines & Immunotherapeutics. 9:1011-1018
HIV-specific ADCC antibodies could play a role in providing protective immunity. We have developed a whole blood ADCC assay that measures NK cell activation in response to HIV peptide epitopes. These HIV peptide-specific ADCC responses are associated
Autor:
Nicole F. Bernard, Ivan Stratov, Matthew S. Parsons, Leia Wren, Stephen J. Kent, Gamze Isitman, Marjon Navis
Publikováno v:
Journal of Virology. 86:4488-4495
Combinations of KIR3DL1 and HLA-Bw4 alleles protect against HIV infection and/or disease progression. These combinations enhance NK cell responsiveness through the ontological process of education. However, educated KIR3DL1 + NK cells do not have enh
Autor:
Amy W. Chung, Gamze Isitman, Marjon Navis, Marit Kramski, Rob J. Center, Stephen J. Kent, Ivan Stratov
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7505-7510
Effective immunity to HIV is poorly understood. In particular, a role for antibody-dependent cellular cytotoxicity (ADCC) in controlling HIV is controversial. We hypothesized that significant pressure from HIV-specific ADCC would result in immune-esc
Publikováno v:
HIV Therapy. 3:633-640
The failure of HIV vaccine concepts based upon either simple antibody or T-cell immunity means that newer concepts in immunity to HIV require urgent investigation. Antibody-dependent cellular cytotoxicity (ADCC) responses, utilizing the arms of humor