Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Ivan Stoilov"'
Publikováno v:
Methods in cell biology. 143
Elastin and collagen levels in tissues are frequently difficult to measure because of each protein's limited solubility. This chapter provides detailed methodology for the determination of elastin, collagen, and total protein levels in a single tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf00d7e20aef46b288792a9dba945536
https://pubmed.ncbi.nlm.nih.gov/29310774
https://pubmed.ncbi.nlm.nih.gov/29310774
Elastin and collagen levels in tissues are frequently difficult to measure because of each protein's limited solubility. This chapter provides detailed methodology for the determination of elastin, collagen, and total protein levels in a single tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bebd679afb54921bd950703383579eb
https://doi.org/10.1016/bs.mcb.2017.08.008
https://doi.org/10.1016/bs.mcb.2017.08.008
Autor:
Takako Sasaki, David E. Birk, Olga Igoucheva, Robert P. Mecham, Machiko Arita, Vitali Alexeev, Mon-Li Chu, Ivan Stoilov, Adele Donahue, Sheila M. Adams, Carmen M. Halabi
Publikováno v:
Journal of Biological Chemistry. 290:21443-21459
Fibulin-4 is an extracellular matrix protein essential for elastic fiber formation. Frameshift and missense mutations in the fibulin-4 gene (EFEMP2/FBLN4) cause autosomal recessive cutis laxa (ARCL) 1B, characterized by loose skin, aortic aneurysm, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc67ef37ccbde32cc962663c6fab5cff
https://doi.org/10.1074/jbc.m115.640425
https://doi.org/10.1074/jbc.m115.640425
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 52:116-128
The pathogenesis of pulmonary fibrosis involves lung epithelial injury and aberrant proliferation of fibroblasts, and results in progressive pulmonary scarring and declining lung function. In vitro, fibroblast growth factor (FGF) 2 promotes myofibrob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c14e9c7ffcdf5bd30a524f9ca1804d8
https://doi.org/10.1165/rcmb.2014-0184oc
https://doi.org/10.1165/rcmb.2014-0184oc
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 12
Chronic proteolytic disruption of elastic fibres within the abdominal aortic wall results in wall vessel expansion to form rupture-prone abdominal aortic aneurysms (AAA). Arresting AAA growth is not possible as adult vascular smooth muscle cells (SMC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebcc7e0c66451543addff44e6e68219a
https://doi.org/10.1002/term.2349
https://doi.org/10.1002/term.2349
Autor:
Ganesh Swaminathan, Robert P. Mecham, Raj R. Rao, Venkat S. Gadepalli, Anand Ramamurthi, Ivan Stoilov
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 11:679-693
Abdominal aortic aneurysms (AAAs) involve slow proteolysis and loss of structural matrix components (collagen and elastin), which lead to wall thinning, weakening and ultimate rupture. At this time, no established non-surgical therapy is available to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b003348c90658de6591c2d04db9612d
https://doi.org/10.1002/term.1964
https://doi.org/10.1002/term.1964
Autor:
Robert Mecham, Ivan Stoilov, Ganesh Swaminathan, Jonathan Fox, Balakrishnan Sivaraman, Maciej Zborowski, Shataakshi Dahal, Lee R. Moore, Anand Ramamurthi, Dhruv R. Seshadri
Publikováno v:
Acta biomaterialia. 52
Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13433eea98db3a8ad0f85937b952987
https://pubmed.ncbi.nlm.nih.gov/27884774
https://pubmed.ncbi.nlm.nih.gov/27884774
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 35
Abdominal aortic aneurysms (AAA) are a leading cause of death in the elderly with over 150,000 new diagnoses annually in the US. They involve bulging of the abdominal aorta due to chronic proteolytic degradation of the wall structural extracellular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba797fd3a7f9c9c1ad143dd66f12e7ea
https://doi.org/10.1161/atvb.35.suppl_1.617
https://doi.org/10.1161/atvb.35.suppl_1.617
Autor:
Robert P. Mecham, Anil G. Jegga, Charu Munjal, Giorgio M. Bressan, Russell A. Norris, J. Michael Smith, Amy M. Opoka, Robert B. Hinton, Ivan Stoilov, Craig J. Thomas
Publikováno v:
Physiological Reports
Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc067925c305e4482cc728e61af04868
https://doi.org/10.14814/phy2.13152
https://doi.org/10.14814/phy2.13152
Autor:
Ganesh, Swaminathan, Venkat S, Gadepalli, Ivan, Stoilov, Robert P, Mecham, Raj R, Rao, Anand, Ramamurthi
Publikováno v:
Journal of tissue engineering and regenerative medicine. 11(3)
Abdominal aortic aneurysms (AAAs) involve slow proteolysis and loss of structural matrix components (collagen and elastin), which lead to wall thinning, weakening and ultimate rupture. At this time, no established non-surgical therapy is available to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d214cdc9cdca8c8b28fdf5a309d84b8f
https://pubmed.ncbi.nlm.nih.gov/25376929
https://pubmed.ncbi.nlm.nih.gov/25376929